DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam22

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_031759145.1	Gene:	adam22 / 100494669	XenbaseID:	XB-GENE-957019	Length:	936	Species:	Xenopus tropicalis

Alignment Length:	939	Identity:	192/939 - (20%)
Similarity:	290/939 - (30%)	Gaps:	307/939 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 PPKKYISGDEDFKYPHQKY-TKEANFAEGAFYDPS-------TGRRLGSSANVADWHQLVHERVR 385
            |.:|| :.:||::: |..| :|...|.....  ||       |..||.        .|..::|.:
Frog   174 PGEKY-NPNEDYQF-HSVYKSKVLEFPIDEL--PSEFWPLNDTSPRLS--------QQTRNQRKK 226

  Fly   386 RATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEIT 450
            |.|..          ..|..||......|.|..|.|:::..|..:. |.......|
Frog   227 RQTRR----------YPRNVEDETKYVELMIVNDHLMYKKHRLSVG-HTNSYAKSV--------- 271

  Fly   451 SLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFL 515
                  |...:.||:        |..|.|..:..:   :..|..|.::...|..    :.:..|:
Frog   272 ------VNMADLIYK--------EQLNTRIVLVAM---ETWATDNKFSISENPL----LTLKEFM 315

  Fly   516 NLHS--LEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRS 578
            ....  ::|.||  ..::|:...|.....|.|::       ||:|...|      ||
Frog   316 KYRRDFIKDKSD--AVHLFSGSQFESSRSGAAYI-------GGVCSLLK------GG-------- 357

  Fly   579 LNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ----ECRPGGLNGNYIMFASATSGD 639
               |:      |....|.|..:|||..:.||.|...|..:    ||:........||      ||
Frog   358 ---GV------NEFGKPDVMAVTLAQSLAHNLGIFSDKKKLLSGECKCEDTWSGCIM------GD 407

  Fly   640 ----RPNNSKFSPCSIRNISNVLDVLVGNTKRDC-----FKASEGAFCGNKIVESGEECDCGFNE 695
                .|  ||||.|:|......|:    |....|     .|..:...|||..||:||||||| ..
Frog   408 IGYYLP--SKFSVCNIEEYHEFLN----NGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCG-TI 465

  Fly   696 EECK---DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE 757
            .||.   .:||                |.||....::|  |.|.||  :.|.|.|.  ...|:|.
Frog   466 AECAVEGGECC----------------KKCTLTQDSEC--SDGLCC--SDCKFNPK--EMICREA 508

  Fly   758 -TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWN----------MT 808
             .:|....||.|.:::||...|:.|...|.:...||..|.|.  ...| .:|.          ..
Frog   509 VNDCDIPETCTGNSSQCPANIHKLDGYQCESMQGLCFGGRCKTRERQCKYIWGEKVSAADKYCYE 573

  Fly   809 KCFLTSTTLPHVSKRK-----------LCD-LACQ-----------DGNDTSTCRSTSEFADKYN 850
            |..:..|...:..:.|           ||. |.|.           ||:.|::  |.......||
Frog   574 KLNIEGTEKGNCGRNKETWIQCNKQDVLCGYLLCTNISSVPRLGELDGDVTTS--SVVNQGKLYN 636

  Fly   851 IQKGGISL---------QPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWI 906
            ...|.:.|         :.|:||..  |...:..:|..:|:
Frog   637 CSGGHVKLDEDTDLGYVEDGTPCGT--GMMCLEHRCLPIDS------------------------ 675

  Fly   907 VDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKK---------------------------RR 944
                       ..|...:||..|.|:.|...||..|                           .|
Frog   676 -----------FNFSTCLGSTNKICSGHGVCSNEVKCICDSFWTGDDCSNFLPYDGIIKPDEGHR 729

  Fly   945 ARRISET---LRAPMNTLRRMQ--------RHPNQRGAGPRSIPPPAHEAQHYSRGGDG------ 992
            ...:..|   :.|...|:..:.        .:.|.|  ..|.||    :..:..:.||.
Frog   730 DEGVISTNIIIGAIAGTILVLALVLGITAWGYKNYR--RERQIP----QGDYVKKPGDADSFYSD 788

  Fly   993 -----RGGGGGGGGRHGGSRSHHQ----QHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRS 1048
                 .........:.....||.|    ..|| :...|..........|.|||......:....|
Frog   789 LPPGVSSNSASSSKKRSAILSHFQISACSIPH-YSISQNISLFCRRSNGLSHSWSERIPDTKHVS 852

  Fly  1049 DGRGPRSTSSGRPQAIASGSGAASGAARSHG------GYGAEQAIPGSIGGGVQAAISSGGVVAR 1107
            |     ...:|||::.:.....:|...:..|      ....|...|..     ..:.|:|.:.:.
Frog   853 D-----VCENGRPRSNSWQGNVSSSRKKLRGKRFRPRSNSTETLSPAK-----SPSSSTGSIASS 907

  Fly  1108 AQLPLPLPPPNGQQQMQQQQQLQLQQPAI 1136
            .:.|.|:||...:::...:|..:|.:.:|
Frog   908 RKYPYPMPPLPDEERKANKQSARLWETSI 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	58/281 (21%)
		Reprolysin_2	450..659	CDD:290307	47/218 (22%)
		Disintegrin	684..776	CDD:278623	31/95 (33%)
adam22	XP_031759145.1	Pep_M12B_propep	71..190	CDD:396235	6/17 (35%)
		Reprolysin	241..440	CDD:396140	57/273 (21%)
		DISIN	455..530	CDD:214490	31/97 (32%)
		ACR	532..673	CDD:214743	28/144 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010