Protein Alignment kuz and adam22

DIOPT Version :10

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: XP_031759145.1
• Gene: adam22 / 100494669
• XenbaseID: XB-GENE-957019
• Length: 936
• Species: Xenopus tropicalis
• Alignment Length: 939
• Identity: 192/939 - (20%)
• Similarity: 290/939 - (30%)
• Gaps: 307/939 - (32%)

  Fly   329 PPKKYISGDEDFKYPHQKY-TKEANFAEGAFYDPS-------TGRRLGSSANVADWHQLVHERVR 385
            |.:|| :.:||::: |..| :|...|.....  ||       |..||.        .|..::|.:
 Frog   174 PGEKY-NPNEDYQF-HSVYKSKVLEFPIDEL--PSEFWPLNDTSPRLS--------QQTRNQRKK 226

  Fly   386 RATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEIT 450
            |.|..          ..|..||......|.|..|.|:::..|..:. |.......|
 Frog   227 RQTRR----------YPRNVEDETKYVELMIVNDHLMYKKHRLSVG-HTNSYAKSV--------- 271

  Fly   451 SLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFL 515
                  |...:.||:        |..|.|..:..:   :..|..|.::...|..    :.:..|:
 Frog   272 ------VNMADLIYK--------EQLNTRIVLVAM---ETWATDNKFSISENPL----LTLKEFM 315

  Fly   516 NLHS--LEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRS 578
            ....  ::|.||  ..::|:...|.....|.|::       ||:|...|      ||
 Frog   316 KYRRDFIKDKSD--AVHLFSGSQFESSRSGAAYI-------GGVCSLLK------GG-------- 357

  Fly   579 LNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ----ECRPGGLNGNYIMFASATSGD 639
               |:      |....|.|..:|||..:.||.|...|..:    ||:........||      ||
 Frog   358 ---GV------NEFGKPDVMAVTLAQSLAHNLGIFSDKKKLLSGECKCEDTWSGCIM------GD 407

  Fly   640 ----RPNNSKFSPCSIRNISNVLDVLVGNTKRDC-----FKASEGAFCGNKIVESGEECDCGFNE 695
                .|  ||||.|:|......|:    |....|     .|..:...|||..||:||||||| ..
 Frog   408 IGYYLP--SKFSVCNIEEYHEFLN----NGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCG-TI 465

  Fly   696 EECK---DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE 757
            .||.   .:||                |.||....::|  |.|.||  :.|.|.|.  ...|:|.
 Frog   466 AECAVEGGECC----------------KKCTLTQDSEC--SDGLCC--SDCKFNPK--EMICREA 508

  Fly   758 -TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPC-LLWN----------MT 808
             .:|....||.|.:::||...|:.|...|.:...||..|.|.  ...| .:|.          ..
 Frog   509 VNDCDIPETCTGNSSQCPANIHKLDGYQCESMQGLCFGGRCKTRERQCKYIWGEKVSAADKYCYE 573

  Fly   809 KCFLTSTTLPHVSKRK-----------LCD-LACQ-----------DGNDTSTCRSTSEFADKYN 850
            |..:..|...:..:.|           ||. |.|.           ||:.|::  |.......||
 Frog   574 KLNIEGTEKGNCGRNKETWIQCNKQDVLCGYLLCTNISSVPRLGELDGDVTTS--SVVNQGKLYN 636

  Fly   851 IQKGGISL---------QPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWI 906
            ...|.:.|         :.|:||..  |...:..:|..:|:
 Frog   637 CSGGHVKLDEDTDLGYVEDGTPCGT--GMMCLEHRCLPIDS------------------------ 675

  Fly   907 VDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKK---------------------------RR 944
                       ..|...:||..|.|:.|...||..|                           .|
 Frog   676 -----------FNFSTCLGSTNKICSGHGVCSNEVKCICDSFWTGDDCSNFLPYDGIIKPDEGHR 729

  Fly   945 ARRISET---LRAPMNTLRRMQ--------RHPNQRGAGPRSIPPPAHEAQHYSRGGDG------ 992
            ...:..|   :.|...|:..:.        .:.|.|  ..|.||    :..:..:.||.
 Frog   730 DEGVISTNIIIGAIAGTILVLALVLGITAWGYKNYR--RERQIP----QGDYVKKPGDADSFYSD 788

  Fly   993 -----RGGGGGGGGRHGGSRSHHQ----QHPHDWDRHQGGHSIVPLPTGGSHSSRNSAANQARRS 1048
                 .........:.....||.|    ..|| :...|..........|.|||......:....|
 Frog   789 LPPGVSSNSASSSKKRSAILSHFQISACSIPH-YSISQNISLFCRRSNGLSHSWSERIPDTKHVS 852

  Fly  1049 DGRGPRSTSSGRPQAIASGSGAASGAARSHG------GYGAEQAIPGSIGGGVQAAISSGGVVAR 1107
            |     ...:|||::.:.....:|...:..|      ....|...|..     ..:.|:|.:.:.
 Frog   853 D-----VCENGRPRSNSWQGNVSSSRKKLRGKRFRPRSNSTETLSPAK-----SPSSSTGSIASS 907

  Fly  1108 AQLPLPLPPPNGQQQMQQQQQLQLQQPAI 1136
            .:.|.|:||...:::...:|..:|.:.:|
 Frog   908 RKYPYPMPPLPDEERKANKQSARLWETSI 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	Pep_M12B_propep	54..149	CDD:460254
		ZnMc_TACE_like	410..677	CDD:239798	58/281 (21%)
		Disintegrin	684..776	CDD:459709	31/95 (33%)
adam22	XP_031759145.1	Pep_M12B_propep	82..190	CDD:460254	6/17 (35%)
		Reprolysin	241..440	CDD:426256	57/273 (21%)
		Disintegrin	455..528	CDD:459709	31/95 (33%)
		ACR	532..673	CDD:214743	28/144 (19%)
		EGF_2	688..712	CDD:400365	5/23 (22%)