Protein Alignment kuz and adam23

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001233135.1
• Gene: adam23 / 100494499
• XenbaseID: XB-GENE-988267
• Length: 815
• Species: Xenopus tropicalis
• Alignment Length: 831
• Identity: 168/831 - (20%)
• Similarity: 261/831 - (31%)
• Gaps: 252/831 - (30%)

  Fly   281 TDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPK--KYISGDEDFKY- 342
            |...|.|.|...::|.....|..|..........:|.::...|::...|.:  .||:.:.:..|
 Frog    48 TQTASHWNETAGSTAGRLTEEDQSSHNNNSRSDSIHSQNNAIQKEITMPSRLVYYINKESESPYH 112

  Fly   343 -------PHQKYTKEANFAEGAFYDPSTGR------RLGSSANVADWHQLVHERVRRATDNGAGD 394
                   ...|:.|..:.|:.:|...:.|.      .|.:.....|:.::.:...:.....| |:
 Frog   113 VLDTKARDQPKHNKAVHLAQASFQIEAFGSTFILDLTLNNGLLSLDYSEIEYSDGKPKLTKG-GE 176

  Fly   395 RGSSGGSGRGREDNK---NTCS---------LYIQT-DPLIWRH-----IREGIADHDRGRKYEV 441
            .....||.||..:::   :||:         .|..| .|:...|     .|..|.:...|.:..|
 Frog   177 HCYYHGSIRGVNNSRVAISTCNGLHGMFDDGTYTYTIHPVDITHSSKSTSRPHIIERTAGSQISV 241

  Fly   442 DEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIK---IDDDSACRNSYNGPHNA 503
            .:.:..|....:..|.|......|..:.......|.|..|::.::   ::|....:.     |.
 Frog   242 HQDSLAESEEKVNSHKTPPTEWLRKRRKRALPAPRGIFEEMKYVELMIVNDHQMYKK-----HR- 300

  Fly   504 FCNEHMDVSNF---------------LN-----------------------LHSLEDHSDFCLAY 530
              :.||..:||               ||                       :..|.|.|.:...:
 Frog   301 --SSHMYTNNFAKSVVNLVDSVYKEQLNTRVVLVAVETWTDKDRIPISPDPIKMLHDFSKYRQHH 363

  Fly   531 VFTYRD----FTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNS 591
            :..:.|    .:.||  ..:..|:....||:|    :.|..||                 ||...
 Frog   364 IKQHADAVHLLSNGT--FHYKRSSMSYFGGVC----SITRGVG-----------------VNEYG 405

  Fly   592 RVPPKVSQLTLAHEIGHNFG---SPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCSIRN 653
            .:.....|  ||..:..|.|   .|.....:|......|..||..:.....|    :||.|||..
 Frog   406 LLLSMAQQ--LAQSLAQNLGIQWEPASRKSKCDCTENFGGCIMEETGVYHSR----RFSKCSIAE 464

  Fly   654 ISNVLDVLVG----NTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQS 714
            ....|:...|    |.....|:.:|   |||..||:|||||||| ..:|...||
 Frog   465 YKEFLNRGGGSCLFNRPTKLFEVTE---CGNGYVEAGEECDCGF-RMDCFGDCC----------- 514

  Fly   715 LNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCK-EETECSWSSTCNGTTAECPEPRH 778
                 |.|:......|  |.|||| :.||.|:|..|  .|: ...||..:..|.|.:.:||....
 Frog   515 -----KKCSLSNGAHC--SDGPCC-NTSCLFLPREY--DCRYAVNECDITEHCTGDSGQCPPNLR 569

  Fly   779 RDDKTMCNNGTALCIRGECS--GSPCL-LWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCR 840
            :.|...|::....|..|||.  .:.|. :|.              :|....|..|.:       :
 Frog   570 KQDGNACDSNQGRCYNGECKTRDNQCKHIWG--------------TKAAGSDKFCYE-------K 613

  Fly   841 STSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKC-------------------------RAV 880
            ..:|..:|.|..|.|   .....|.....:|. ||.|                         |.|
 Frog   614 LNTEGTEKGNCGKDG---DRWIQCSKHDVFCG-FLLCANVSKSPRIGKLEGDIPPTYINHQGRVV 674

  Fly   881 DADGPLLRLKN-----------------LLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFI 928
            |..|..:.|.:                 :.|:||.|..         :|:.:....|    ||..
 Frog   675 DCSGAHVILDDETDMGYVEDGAPCGPSMMCLDRKCLPI---------HLLNISNCPF----GSNG 726

  Fly   929 KCCAVHTPSSN-------------------PKKRRARRISETLRAPMNTLR 960
            |.|:.|...||                   |||....:..:..:..|.|.|
 Frog   727 KVCSGHGVCSNEATCICSSTWAGTDCSIYDPKKEPPTKKDDLPKVSMATNR 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	61/333 (18%)
		Reprolysin_2	450..659	CDD:290307	45/256 (18%)
		Disintegrin	684..776	CDD:278623	32/92 (35%)
adam23	NP_001233135.1	Pep_M12B_propep	129..231	CDD:279848	18/102 (18%)
		Reprolysin	283..481	CDD:279729	42/234 (18%)
		ZnMc_adamalysin_II_like	283..479	CDD:239797	41/232 (18%)
		Disintegrin	496..568	CDD:278623	32/93 (34%)
		ACR	571..712	CDD:214743	30/165 (18%)
		DUF3844	729..797	CDD:289707	10/49 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010