DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adamts19

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_031748801.1	Gene:	adamts19 / 100494209	XenbaseID:	XB-GENE-980450	Length:	1205	Species:	Xenopus tropicalis

Alignment Length:	833	Identity:	168/833 - (20%)
Similarity:	286/833 - (34%)	Gaps:	257/833 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 RPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAED 249
            :.|..|.|.:|..|....:......::..:|:::  .:.||.|:|:|:...::..|.|.||....
Frog    62 KALVSSGTPSTDRNHSNIHSSSSYNQAAVSSREV--RSVSSPSTTSTYYHLSQEEEQENERFEPQ 124

  Fly   250 ELDFH----SIIYKESHVEDAYENVR---EGHVAGCGITDEVSQWMENIQNSAVEELPEPM--SK 305
            :: :|    |.|.||.....:..|..   ....:|..||.     ::..:|:....|..|:  .:
Frog   125 DM-YHLSQFSWISKEKTTNASSPNASIPVSVLSSGKSITS-----LKQSENAGKMRLKIPVFGLE 183

  Fly   306 DYQKLHR-----------KQLHKK---SAPQQQQQP---------HPPK-----------KYISG 336
            .|..|.|           :|.|::   |:.|...:.         ||..           .:|..
Frog   184 LYLLLKRDNHFLAPGFVVEQRHREWRGSSVQDTDRECYYSGTVLRHPGSFASFSTCGGLMGFIQM 248

  Fly   337 DEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGS 401
            :|||.|                .:|     |..:..||.....|:.| :|||:|.:.::.|:...
Frog   249 NEDFIY----------------IEP-----LNQTMAVAGHAHRVYRR-KRATENKSWEKKSNHQP 291

  Fly   402 GRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEI-------TSLIAHH--- 456
            ..|..|.:.|            |:.:  .:|..||::|...:..:..|       .:::::|
Frog   292 SCGITDRRRT------------RNYK--ASDTGRGKRYSFKQAQQYNIETVVVADPAMVSYHGPE 342

  Fly   457 ------VTAVNYIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPH-----NAFC----- 505
                  :|.:|.:|...:........|:|  |.::.:..:|.. :.|.|.|     .:||
Frog   343 ATRKFILTILNMVYNLFQHKSLGVQMNLR--VTKLVLLHESPV-DMYIGHHGEKMLESFCKWQLE 404

  Fly   506 ------NEHMDVS-------NFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGI 557
                  :.||::|       :.::...|...:|||:     ::|....|:|:|::       .|:
Frog   405 EFGKKNDVHMEMSTSWGEEYSAVDAAILITRTDFCV-----HKDEPCDTVGIAYL-------NGM 457

  Fly   558 C-EKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECR 621
            | :|.|.......|        ||..                 .|:|||:|||.|..||   ...
Frog   458 CSDKRKCIIAEDNG--------LNLA-----------------FTIAHEMGHNMGINHD---NDH 494

  Fly   622 PGGLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVES- 685
            |...:|.:||......|....:..:|.||..::...|.....|    |...:......:.|:.|
Frog   495 PSCADGLHIMSGEWIKGQNLGDVSWSRCSREDLERFLRSKASN----CLLQTNPQSLSSGIIPSK 555

  Fly   686 --------GEECDCGFNE-----EECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGP- 736
                    .|:|...|..     ||.:...|              :...|....:.:|..:..|
Frog   556 VPGMTYTADEQCQILFGPAASFCEEMQHVIC--------------TGLWCKLDGEKECKTNLDPP 606

  Fly   737 -----C-----CLSNSCTFVPTSYHQKCKEETECSWSS--TCNGTTAECPEPRHRDDKTMCNNGT 789
                 |     |.:..||.:.:|     .|.....|||  ||:.|.:.....|.|..::..|.|.
Frog   607 MDGTRCGLEKWCTAGECTSIASS-----AEHLSGEWSSWGTCSRTCSTGISSRQRKCQSQGNEGR 666

  Fly   790 ---------ALCIRGEC-SGSPCLL-WN-MTKCFLTS-TTLPH-----VSKRKLCDLACQD-GND 835
                     .:|...|| :.:|... |. .|..|.|| ....|     :::.|.|.|.|.. |.|
Frog   667 QCNDPKIQHRICENPECPANTPNFRDWQCQTFSFRTSYQKNKHQWQSIINEEKPCALFCSALGKD 731

  Fly   836 TSTCRSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFL--KCRAVDADGPL 886
            ....     .|:|         :..|:||.  |...|:..  :|:.|..||.|
Frog   732 QPIL-----VAEK---------VLDGTPCG--QNGLDICSNGRCQKVGCDGIL 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	59/306 (19%)
		Reprolysin_2	450..659	CDD:290307	49/241 (20%)
		Disintegrin	684..776	CDD:278623	22/118 (19%)
adamts19	XP_031748801.1	Pep_M12B_propep	150..272	CDD:396235	24/147 (16%)
		ZnMc_ADAMTS_like	323..540	CDD:239801	53/263 (20%)
		ADAM_CR_2	557..624	CDD:407643	11/80 (14%)
		TSP1	635..684	CDD:214559	12/48 (25%)
		ADAM_spacer1	788..898	CDD:368694
		TSP1_ADAMTS	922..974	CDD:408800
		TSP1_ADAMTS	978..1034	CDD:408800
		TSP1_ADAMTS	1038..1080	CDD:408800
		TSP1_ADAMTS	1089..1141	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910