DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam17

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_031757449.1	Gene:	adam17 / 100492947	XenbaseID:	XB-GENE-492534	Length:	855	Species:	Xenopus tropicalis

Alignment Length:	1044	Identity:	226/1044 - (21%)
Similarity:	368/1044 - (35%)	Gaps:	339/1044 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 CAFNIVF---------------VSIIFIIIVNGYAKDISGVKRGHER---------LNEYISHYE 45
            |...:||               |.:||.:::.....:...:..|.::         |:..:|.|:
Frog     2 CVLPVVFTDNMKVLRLMGQLSLVEVIFALLLCLVVAEADHIPFGSQKEMPAKHQAGLDSLLSEYD 66

  Fly    46 TLNYDHEHIRASHNRARRSVTKDQYVH--LKFASHGRDFHLRLKRDLNTFSNKLD--FYDSKG-- 104
            .|:.....   .|:..:|.:.....:.  |.|.:..|.|.|.|.......|..|:  ..|..|
Frog    67 VLSLSSIQ---QHSLRKRDLQSQSQLERMLSFTALQRHFKLYLTSSTELVSENLEALVLDGNGKE 128

  Fly   105 -PIDVSTDHIYEGEVIGDRNSYVFGSIHNGVFEGKIITERDAYYVEHAKHYFPTNRTATTTPPST 168
             ...|.....:.|.|:|:.||.|...|.:|.|..:|.|:.:.|.:|
Frog   129 KKYQVKWSDFFTGHVVGEHNSKVLAHIGDGDFTARITTDGEEYNIE------------------- 174

  Fly   169 STTSSATTATKSTQPTRPLAKSNTSTTAVNSKTENFIKKIAESTTTSQQLPEYTESSSSSTTTFP 233
                             ||.:                               :.|::|..
Frog   175 -----------------PLWR-------------------------------FVENTSGD----- 186

  Fly   234 PTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEE 298
                                :.::|:...::| :..::...|.|
Frog   187 --------------------NMLVYRSGDIKD-FSRLKSSKVCG--------------------- 209

  Fly   299 LPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPST 363
                                              ||...||. :.:::.|.|:  |||..|
Frog   210 ----------------------------------YIKPKEDL-FKNEQDTAES--AEGDDY---- 233

  Fly   364 GRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIRE 428
                           |..|:.:||                |.:..:|||.:.:..|...::::..
Frog   234 ---------------LHREKRQRA----------------GPDSLRNTCKMLVVADHRFFKYMGR 267

  Fly   429 GIADHDRGRKYEVDEKTREEITSL--IAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKI---- 487
            |                 ||.|::  :...:..|:.|||||.:| ..:.:....::::|.:
Frog   268 G-----------------EESTTINYLIELIDRVDDIYRNTSWD-NNQWKGYGVQIEQIIVHKEP 314

  Fly   488 DDDSACRNSYNGPHNAFCN---EHMDVSNFLNLHSL---EDHSDFCLAYVFTYRDFTGGTLGLAW 546
            ::.:..:..|| ...||.|   :..||...|...|.   |..:..|||::|||:||..||||||:
Frog   315 ENVTQGQKHYN-MARAFPNPDKDAWDVKQLLEQFSYDISEKAAQVCLAHLFTYQDFDMGTLGLAY 378

  Fly   547 VAS-ASGASGGICEKYKTYTETVGGQYQS--TKRS--LNTGIITFVNYNSRVPPKVSQLTLAHEI 606
            |.| .....||||.|          .|::  :|::  ||||:.:..||...:..|.:.|...||:
Frog   379 VGSHKPNTHGGICPK----------AYENDLSKKAVYLNTGLTSTKNYGKTILTKEADLVTTHEL 433

  Fly   607 GHNFGSPHDYP---QECRPG-GLNGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKR 667
            ||||||.|| |   :.|.|. ...|.::|:..|.|||..||..||.||..:|   |..|:..:.
Frog   434 GHNFGSEHD-PDSMEACAPSEDHGGKFVMYPIAVSGDHENNKMFSSCSRESI---LRTLMAKSP- 493

  Fly   668 DCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSP 732
            .|||......|||..|:.|||||.|...:. .|.||               ...|..:....||.
Frog   494 ICFKERNNKVCGNSRVDEGEECDPGLLHQH-NDPCC---------------TSDCKFQPGVHCSD 542

  Fly   733 SQGPCCLSNSCTFVPTSYHQKCKE--ETECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRG 795
            ...|||  ..|.|  .|..:||:|  ...|...|.|.|:::|||.|.:.::.|:|.: ...|:.|
Frog   543 RNSPCC--RGCQF--ESAQKKCQEAINATCKGESYCTGSSSECPTPGNAENDTVCVD-LGKCVNG 602

  Fly   796 ECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQP 860
            ||.....:..|:..|....|       ...|.:.|:|.|  ..|....:..|.:      :.|:.
Frog   603 ECRPFCEIERNLKSCACNDT-------ENSCKVCCRDEN--GVCSPQKDQHDHF------LYLRK 652

  Fly   861 GSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWY-LVVLMGVAFIVVM 924
            |.||.  .|:||...||.....| .:.|:.: .:::.::....:::.||.. .||:..:.|.:.:
Frog   653 GKPCT--VGFCDANGKCEKQVQD-VIERIWD-FIDKLSINMFGKFLADNIVGSVVVFSLLFWIPL 713

  Fly   925 GSFIKCCAVHTPSSNPKKRRARRISETLRA---PMNT--LRRMQRHPNQRGAGPRSIPPPAHEAQ 984
            ...:.|.         .|:..:|..||.::   |.|.  |..|.       :.|..|..|:..:|
Frog   714 SILVHCV---------DKKLDKRYEETTKSLFTPSNVEMLSSMD-------SAPVRIVKPSPSSQ 762

  Fly   985 HYSR 988
            ..:|
Frog   763 ATNR 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	88/287 (31%)
		Reprolysin_2	450..659	CDD:290307	76/229 (33%)
		Disintegrin	684..776	CDD:278623	28/93 (30%)
adam17	XP_031757449.1	Pep_M12B_propep	75..191	CDD:396235	30/207 (14%)
		ZnMc_TACE_like	249..503	CDD:239798	88/287 (31%)
		Disintegrin	510..584	CDD:395147	28/93 (30%)
		ADAM17_MPD	607..668	CDD:406977	17/77 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010