DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and LOC100491788

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001265673.1	Gene:	LOC100491788 / 100491788	-ID:	-	Length:	725	Species:	Xenopus tropicalis

Alignment Length:	958	Identity:	263/958 - (27%)
Similarity:	406/958 - (42%)	Gaps:	284/958 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FNIVFVSIIFIIIVNGYAKDISGVKRGHERLNEYISHYETLNYDHEHIRASHNRARR-SVTKDQY 70
            ||...| :.|:::....:...|.|.:     ..::.:||.|::|:..:...|.|::| |..:.:.
Frog     7 FNFYMV-VAFLLVKGEISAGSSCVTK-----KSFLKYYENLSFDNHDLDQKHKRSKRASEEEKEP 65

  Fly    71 VHLKFASHGRDFHLRLKRDLNTFSNKLDFYDSKGPIDVSTDHIYEGEVIGDRNSYVFGSIHNGVF 135
            ::|.|.::.|.|.|.|:||||.|::......:...:.|....:|.|.:..:..|:..|||.:|.|
Frog    66 IYLDFFAYKRKFALILRRDLNVFADDFQVVSNNRTLSVDISFVYSGALKDEFGSFCHGSIIDGHF 130

  Fly   136 EGKIITERDAYYVEHAKHYFPTNRTATTTPPSTSTTSSATTATKSTQPTRPLAKSNTSTTAVNSK 200
            ||.|.|:...:|||:
Frog   131 EGFIQTKNGTFYVEY-------------------------------------------------- 145

  Fly   201 TENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVED 265
                                                     ||..|..:|    |.||   |.||
Frog   146 -----------------------------------------EKNSNGTEE----SYIY---HEED 162

  Fly   266 AYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQQPHPP 330
                      .|..|..::..:             |...|.||.|.:
Frog   163 ----------IGYSILKDIKSF-------------ELTLKKYQFLEK------------------ 186

  Fly   331 KKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDR 395
            .|:.:.:||.                                         .|.:|:.|.
Frog   187 MKWKAKEEDL-----------------------------------------TRKKRSLDL----- 205

  Fly   396 GSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAHHVTAV 460
                        ::.||.||::.|.|.::..                 .:.|::.|.|:.::|:|
Frog   206 ------------SRTTCLLYLKADYLFYKRF-----------------NSIEQVISQISSYMTSV 241

  Fly   461 NYIYRNTKFDGRTEHRNIRFEVQRIKIDDD----SACRNSYNGPHNAFCNEHMDVSNFLNLHSLE 521
            |.||....|:|   .::|.|:::.:.:..:    ||..:::.||           ...|.|||..
Frog   242 NAIYEQANFNG---IKDINFKIKTLNVVQEDKPSSAMHSTFIGP-----------EKLLMLHSES 292

  Fly   522 DHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITF 586
            ..:::||:|:.|.||: .|.||||| ....|.|||||.||..|     |:..:|..:|||||:|.
Frog   293 VWNNYCLSYLITDRDY-NGVLGLAW-NGRPGNSGGICSKYSQY-----GENPNTFVTLNTGIVTI 350

  Fly   587 VNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQEC------RPGGLNGNYIMFASATSGDRPNNSK 645
            ..|...:||::..:|||||:||:.|:|||..:||      .|   ||||:||..|..|::.||.|
Frog   351 QKYGQYLPPRLIHITLAHELGHSLGAPHDESEECARFDTTSP---NGNYLMFPYAMDGNQYNNDK 412

  Fly   646 FSPCSIRNISNVLDVLVGNTKRD-CFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLIS 709
            ||.|||..|.|:|.|     |:| ||..|:...|||:|||.||:||.|:|:   .|.|||..
Frog   413 FSSCSIYYIGNLLRV-----KKDQCFVESDRPTCGNQIVEEGEQCDVGYND---NDPCCYGA--- 466

  Fly   710 EYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETECSWSSTCNGTTAECP 774
                   .||..||.:...|||||||.|| |:.|:::|.|  |:|::|.||:..:.|.|.:|:||
Frog   467 -------ESALQCTLKPGKQCSPSQGLCC-SHLCSYMPKS--QRCQDEAECTLENNCTGDSAKCP 521

  Fly   775 EPRHRDDKTMCNNGTALCIRGECSGSPCLLWNMTKCFLTSTTLPHVSKRKLCDLACQDGNDTSTC 839
            :|..:.:.|:||.||.:||.|.|..|.|..:.:.:|...|.     |..:.|.|.||:.::..:|
Frog   522 KPLPKSNYTLCNLGTRICINGMCRQSVCAKFGLEQCDCDSE-----SMLEKCQLCCQEPDNVYSC 581

  Fly   840 RSTSEFADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLKNLLLNRKTLQTVAE 904
            :||.....::..::..:.|.|||||.|.|||||.|..||.||||||:.||||..||...|:..|.
Frog   582 KSTKSVELEHFFKRALLQLPPGSPCGNRQGYCDKFHICRLVDADGPIARLKNSFLNLIELEDPAT 646

  Fly   905 WIVDNWYLVVLMGVAFIVVMGS--FIKCCAVHTPSSNPKKRRARRISE 950
            |:...|:.::|:.:....:|..  ||....:.:.....:.:..||.::
Frog   647 WMKTRWWAILLIILTLAALMAGTVFIFGRTLDSDKEKQQNKEERRSTQ 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	97/277 (35%)
		Reprolysin_2	450..659	CDD:290307	83/218 (38%)
		Disintegrin	684..776	CDD:278623	38/91 (42%)
LOC100491788	NP_001265673.1	Pep_M12B_propep	52..144	CDD:279848	29/91 (32%)
		ZnMc	208..439	CDD:294052	97/276 (35%)
		Reprolysin_2	227..425	CDD:290307	84/221 (38%)
		Disintegrin	447..524	CDD:278623	38/92 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	81	1.000	Domainoid score	I8378
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47506
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010