DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam11

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001243157.1	Gene:	adam11 / 100491446	XenbaseID:	XB-GENE-966539	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	926	Identity:	193/926 - (20%)
Similarity:	272/926 - (29%)	Gaps:	332/926 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 SSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWME 289
            ||...|..||.|.:.:..|.           ...|..|.:..:.:...||.:|.
Frog    25 SSLVNTIVPPITAHSDSPKR-----------WYQKLDHTQITHPSRLVGHTSGA----------- 67

  Fly   290 NIQNSAVEELPEPMSKDYQKLHRKQLHK--KSAPQQQQQPHP----------PKKYISGDEDFKY 342
                               :.||.||:.  :|.....|..|.          .||.|.   |.:.
Frog    68 -------------------ETHRYQLNTRVRSENPNDQDAHVAHASFLVTFLEKKMIL---DLEL 110

  Fly   343 PH----QKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSGR 403
            .|    .||.:.       .||......:.:.....| |.....::|...|:.|......|.||
Frog   111 NHLLLSSKYVER-------HYDEDNNSYVKTGGTSGD-HCYYQGKLRGVEDSWAAISTCHGLSG- 166

  Fly   404 GREDNKNTCSLY---IQTDPLIWRHIREGIADHDRGRKYEVDEKTRE---EITSLIAHHVTAVNY 462
            ...|...|.::|   ..|:...|.|..|.|            :|..|   |:.::|.........
Frog   167 AFSDGVYTYTIYPLKQSTETEKWPHAIERI------------KKCTEPDCELHTIIPGSKIRRKR 219

  Fly   463 IYRNTKFDGRTEHRNIR---------FEVQRIKIDDDSACRNSYNGPHNAFCNEHMD-------- 510
            ..|.|.....||.:.:.         |:.||..:...|:...|.....:....|.::
Frog   220 QVRRTSHSALTETKYVELMVVNDRYLFDQQRQSVVLTSSFAKSVVNLADVIFREQLNTRIVLVGM 284

  Fly   511 ------------------VSNFLNLHSLE--DHSDFCLAYVFTYRDFTGGTLGLAWVASASGAS- 554
                              :..|:.....|  ||||  ..::|:.|.|.         :|.|||:
Frog   285 ETWTSTDKITGSEDPLQVLDEFMRYRRAEILDHSD--TTHLFSGRTFK---------SSRSGAAY 338

  Fly   555 -GGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ 618
             ||||      :.:.||           |:..:.|..      |..:|||..:|.|.|...:..:
Frog   339 FGGIC------SPSHGG-----------GVNEYGNIG------VMAVTLAQTLGQNLGMMWNKLR 380

  Fly   619 ----ECRPGGL--------NGNYIMFASATSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDC-- 669
                :|:...|        .|.|:            ..|||.||:...|..|....|:    |
Frog   381 TTAGDCKCPDLWLGCIMEDTGYYL------------PQKFSRCSVDEYSQFLQDGGGS----CLF 429

  Fly   670 ---FKASEGAFCGNKIVESGEECDCGFNEEECK----DKCCYPRLISEYDQSLNSSAKGCTRRAK 727
               .|..:...|||..||.||||||| :..||.    ..||                |.||....
Frog   430 NKPLKLLDPPSCGNGFVELGEECDCG-SPAECNKSGAGNCC----------------KKCTLSHD 477

  Fly   728 TQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTAL 791
            ..|  |.|.||  ..|.:.|..  ..|:.. .||....||.|.::.||...|:.|...|:|....
Frog   478 AMC--SDGLCC--RGCKYEPRG--TVCRGSLNECDVPETCPGDSSVCPANLHKQDGYFCDNEQGR 536

  Fly   792 CIRGECS--GSPC-LLWNMTK----CF----LTSTTLPHVSKRK-----------LCD-LAC--- 830
            |..|.|.  ...| .||..:.    |:    :..|...:..:.:           ||. |.|
Frog   537 CFGGRCKTRDRQCHALWGRSASDRFCYEKLNIEGTEKGNCGRDRQNWIQCSKQDVLCGYLLCSNI 601

  Fly   831 ----QDGNDTSTCRSTSEF-ADKYNIQKGGISLQPGSPCDNFQGYCDVFLKCRAVDADGPLLRLK 890
                |.|.......|.|.: .::|...:||..:.|...|   .||.:....|      ||.:
Frog   602 SGIPQIGELNGDITSMSFYHQNRYLDCRGGQVMLPDGSC---LGYVEDGTPC------GPNM--- 654

  Fly   891 NLLLNRKTLQTVA---EWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRARRISETL 952
             :.|.|:.|...|   .....:|..|:                |:.|...||..|...
Frog   655 -MCLERRCLPASAFNFSTCPGSWNGVI----------------CSDHGVCSNEGKCIC------- 695

  Fly   953 RAPMNTLRRMQRHPNQRGA-----GPRSIPPPAHEAQHYSRGGDGRG-----------------G 995
                        ||...|.     .|..||.|....:.| :|..|..                 |
Frog   696 ------------HPEWTGKDCSVYDPLPIPKPTGVVEKY-KGPSGTNIIIGSIAGAVLIAAIVLG 747

  Fly   996 GGGGG------GRHGG 1005
            |.|.|      ||.||
Frog   748 GTGWGFKNIRRGRSGG 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	63/328 (19%)
		Reprolysin_2	450..659	CDD:290307	49/259 (19%)
		Disintegrin	684..776	CDD:278623	30/96 (31%)
adam11	NP_001243157.1	Pep_M12B_propep	<116..193	CDD:366707	18/85 (21%)
		Reprolysin	233..432	CDD:366632	47/248 (19%)
		Disintegrin	447..521	CDD:365943	30/96 (31%)
		ACR	525..663	CDD:214743	31/150 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920