DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam9

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	NP_001233130.1	Gene:	adam9 / 100491265	XenbaseID:	XB-GENE-976453	Length:	863	Species:	Xenopus tropicalis

Alignment Length:	754	Identity:	170/754 - (22%)
Similarity:	238/754 - (31%)	Gaps:	289/754 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 NLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLN 580
            :|.||..|..   |.:...:.| |||.|:|:|       |.:|                 .||..
Frog   280 SLVSLRRHDS---AQLVLKKGF-GGTAGMAFV-------GTVC-----------------SRSHA 316

  Fly   581 TGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSK 645
            .||..|.:||.:....:    :|||:|||.|..||..:.|...  ....||.:.||     .:..
Frog   317 GGINVFSHYNVQSFASI----VAHELGHNLGMNHDDGRNCLCS--VDTCIMNSGAT-----GSKN 370

  Fly   646 FSPCSIRNISNVLDVLVGNT------KRDCFKASEGAFCGNKIVESGEECDCGFNEEEC-KDKCC 703
            ||.||..:... |.:..|.|      |.|  :|....|||||:|:.||||||| :.:|| ||.||
Frog   371 FSSCSEEDFEK-LTLSKGGTCLLNMPKPD--EAYSAPFCGNKLVDIGEECDCG-SPKECEKDPCC 431

  Fly   704 YPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKE-ETECSWSSTCN 767
            .|..              |..|:..||  :.|.||  .:|.|  :|....|:. ..||.....||
Frog   432 EPGT--------------CKLRSGAQC--AYGTCC--QNCRF--SSGGTVCRAVANECDLPEYCN 476

  Fly   768 GTTAECPEPRHRDDKTMCNNGTALCIRGECS--GSPCLLWNMTKCFLTSTTLPHV---------- 820
            |::..|....:..:...|.|..|.|..|.|.  .:.|.....:|    :.:.|.|
Frog   477 GSSPFCQPDVYIQNGHPCQNSKAYCYNGMCQYYDAQCQAIFGSK----AKSAPPVCYQEVNSKGD 537

  Fly   821 ---------SKRKLCD--------LACQD------------------GNDTSTC-----RSTSEF 845
                     |..:.||        |.|::                  ...|:.|     :..|:.
Frog   538 RFGNCGFQGSDYRKCDTRNARCGKLQCENVETMPVFGIRPSYIQTPIHGTTTICWGVDFQLGSDV 602

  Fly   846 ADKYNIQKGGISLQPGSPCDNFQGY--------CDVFLKC------------------------- 877
            .|...:.: |.....|..|..||..        |||..||
Frog   603 PDPAMVNE-GTKCDEGKICSKFQCVDASVLQYDCDVQKKCGGNGVCNTNKNCHCNEGWAFPNCQT 666

  Fly   878 ----RAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSS 938
                .::|: ||....|:..|.             :..||....:..::.:|:|:..      ..
Frog   667 KGYGGSIDS-GPTYNDKDTSLR-------------DGLLVFFFLIVPLLALGAFVFF------RR 711

  Fly   939 NPKKRRARRISETLRAPMNTLRRMQRH----PNQRGAGPRSIPPPAHEAQHYSRGGDGRGGGGGG 999
            |..|||..|           .:|.|.|    .||.|...::..||.:.|      ..|||....|
Frog   712 NELKRRFCR-----------KKRSQAHEVDNKNQTGGERQASGPPRNTA------APGRGVPNPG 759

  Fly  1000 GGRHGGSRSHHQQHPHDWDRHQGGHSIVP----LPTGGSHSSRNSAANQARRSDGRGPRSTSSGR 1060
            ..|:                   .|::.|    .|||...:..|.|.||       ||    ||.
Frog   760 PPRN-------------------AHNVPPNRGTQPTGPPRNMPNPAQNQ-------GP----SGP 794

  Fly  1061 PQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPLPLPP------PNG 1119
            |:.:     ..:|..||                                .|...||      ||.
Frog   795 PRNV-----PPAGPYRS--------------------------------TPATSPPHSTPYQPNN 822

  Fly  1120 ----QQQMQQQQQLQLQQPAISPQQQPQQAFYTPKELPP 1154
                ...::|.|....:.|.  |.|:...|..||....|
Frog   823 FAVPTYTVKQPQHTPSRPPL--PHQREAAANITPSRPAP 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	45/166 (27%)
		Reprolysin_2	450..659	CDD:290307	39/142 (27%)
		Disintegrin	684..776	CDD:278623	31/93 (33%)
adam9	NP_001233130.1	Pep_M12B_propep	47..155	CDD:279848
		Reprolysin	201..395	CDD:279729	42/154 (27%)
		ZnMc_adamalysin_II_like	201..393	CDD:239797	42/152 (28%)
		Disintegrin	414..486	CDD:278623	31/92 (34%)
		ACR	489..627	CDD:214743	24/142 (17%)
		RCR	692..862	CDD:304939	53/260 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920