DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and XB990656

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_004915886.2	Gene:	XB990656 / 100486640	XenbaseID:	XB-GENE-990657	Length:	791	Species:	Xenopus tropicalis

Alignment Length:	886	Identity:	193/886 - (21%)
Similarity:	292/886 - (32%)	Gaps:	332/886 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 AEDELDFHSIIYKESHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLH 311
            ||.|:.|..::......:..||                .||.:|:..|            .|.|.
Frog    23 AEYEIVFPQLVGTRERRDLHYE----------------EQWSDNLLYS------------IQTLT 59

  Fly   312 RKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEANF--------AEGAFY--------D 360
            .|.|.|....:....        ||.|.|     .|:|||.|        :...:|        |
Frog    60 HKLLLKLQRNRDLVS--------SGFERF-----TYSKEAGFQVFNSTQLSHNCYYYGEVEGMND 111

  Fly   361 P----STGRRLGSSANVADWHQLVHERVRRATDN----------------GAGDRGSSGGSG--- 402
            .    ||...|.....:|:.|..: |.|..:|:.                |.||..:.....
Frog   112 SLLAISTCDGLRGVMYMAEMHYGI-EPVENSTNGEHRLFQIQEPSGPSICGVGDIDTESSHSPLP 175

  Fly   403 ---RGREDNKNTCSLYIQTDPLIWRHIREG-IADHDRGRKYEVDEKTREEITSLIAHHVTAVNYI 463
               |.|...::     :.|.|   .::..| :.|:.|   |:.|   ...:|::....|..:|.:
Frog   176 VNFRLRRAKRS-----VLTTP---SYVELGVVVDNLR---YQAD---NSNMTAVEVETVLLINIV 226

  Fly   464 YRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDV----SNFLNLHSLEDHS 524
                  |....:.|||..:..:.:.|.       |.|.:.......||    :|:.|.::....:
Frog   227 ------DSMFRYLNIRIVLISLTVFDQ-------NNPFDVQSGTAGDVLGRFTNWKNQNTGLKRT 278

  Fly   525 DFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNY 589
            |  ::::...|...|..:|:|:|       |.:|..                 |::|.|..|
Frog   279 D--ISHLLIGRGSYGAVIGMAFV-------GTVCSP-----------------SVDTSISAF--- 314

  Fly   590 NSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASATSGDRPNNSKFSPCS---- 650
            ::...|:.....:|||:|||.|..|| ...| |||    |||: ||..|.:    .||.||
Frog   315 SAGKTPQAHAPVVAHELGHNLGMSHD-DTTC-PGG----YIMY-SADIGAK----NFSSCSATDF 368

  Fly   651 -----------IRNISNVLDVLVGNTKRDCFKASEGAFCGNKIVESGEECDCGFNEEECKDKCCY 704
                       ::|:.|...||...|            |||.|||:||||||| :.:||::.||
Frog   369 ENLILRGGGACLKNLPNPSQVLSIPT------------CGNNIVETGEECDCG-SPQECQNPCC- 419

  Fly   705 PRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETE-CSWSSTCNG 768
                         .|..|...:.::|  .||.||  .:|.|....  ..|:...: |.....|||
Frog   420 -------------QAATCKLTSGSKC--GQGLCC--ENCQFKVAG--TPCRSIADTCDLPEYCNG 465

  Fly   769 TTAECPEPRHRDDKTMCNNGTALCIRGECSGSPCLLWNM---------TKCFLTSTTLPHVSKRK 824
            |.|.||...:..:...|||....|..|.|........|:         .:||..:..|.  .:..
Frog   466 TYALCPVDEYIMNGFPCNNSRNYCYSGVCQNYDAQCRNLFGKDTRKAVDQCFQQANLLG--DQYG 528

  Fly   825 LCDLACQDGNDTSTCRSTSEFADK------------------------------YNIQKG----- 854
            .|.:|   |||...|.:......|                              .:..:|
Frog   529 NCGMA---GNDYKKCATVDSLCGKLQCTGNPQPILNGKVQSLFANQDPSFPCLSVDFNQGPDVPD 590

  Fly   855 ------GISLQPGSPCDNFQ-------GY-CDVFLKCR--------------------------- 878
                  |.|...|..|.|:.       || |||..||.
Frog   591 PGLVHQGTSCGDGLACVNYACVNATNLGYNCDVKTKCNDRGVCNNNGNCHCNYGWAPPYCDRVGY 655

  Fly   879 --AVDADGPL-----LRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTP 936
              ::|: ||.     || ..||:               ::|:||..:..|:|:  |||..|:
Frog   656 GGSIDS-GPTHIDTSLR-DGLLI---------------FFLLVLPILILIIVV--FIKRDAL--- 698

  Fly   937 SSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIP 977
                ::|..:|.:...||  |..|:.|:..|....  ||:|
Frog   699 ----QRRFCKRWNRRRRA--NERRQQQQQQNNNAT--RSVP 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	62/286 (22%)
		Reprolysin_2	450..659	CDD:290307	52/227 (23%)
		Disintegrin	684..776	CDD:278623	30/92 (33%)
XB990656	XP_004915886.2	Pep_M12B_propep	26..146	CDD:396235	32/161 (20%)
		ZnMc_adamalysin_II_like	193..382	CDD:239797	55/247 (22%)
		DISIN	401..475	CDD:214490	30/94 (32%)
		ACR	477..613	CDD:214743	23/140 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920