DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adamts12

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_017946319.2	Gene:	adamts12 / 100380018	XenbaseID:	XB-GENE-959575	Length:	1569	Species:	Xenopus tropicalis

Alignment Length:	1189	Identity:	228/1189 - (19%)
Similarity:	348/1189 - (29%)	Gaps:	484/1189 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 ELPEPMSKD-------YQKLHRKQLHKKSAPQQQQQPHPPKKYISGDEDFKYPHQKYTKEAN--F 353
            |:.||:..|       |...||:   |:|...|...             ::..|:.:....|  |
Frog    65 EVVEPVKVDEKGNFLSYNLQHRR---KRSVASQAIH-------------YRIHHKTHNLFFNLTF 113

  Fly   354 AEGAFYDP-STGRRLGSSANVADWHQLVHERVRRATDNGA------------------------- 392
            .:|...|. ...||.|:|:         |.|:.....||.
Frog   114 RDGFLSDNFILERRNGNSS---------HARISPQLGNGCHLIGTAQRAHVGGGVAAISVCNGLA 169

  Fly   393 -------GD------RGSSGGSG--------------RGRED-----------NKNTCSLYIQTD 419
                   ||      .|::..||              |.|.:           |.|:.|:..|.
Frog   170 GFFRLPDGDYFIEPFHGATQVSGKPHQHIIYQRDSPHRNRRELPISTGDFCAVNDNSKSVLQQE- 233

  Fly   420 PLIWRHIREGIADHDRGRKYEVDEKTREE--------ITSLIAHH------------VTAVNYIY 464
                |...|....|..|||......::|.        .|.:||:|            :..|..::
Frog   234 ----RQREEWERKHLNGRKISQRSVSKERWVETLVVADTKMIAYHGSNNVESYIFTIMNMVTGLF 294

  Fly   465 RNTKFDGRTEHRNIRF-----EVQRIKIDDDSACRNSYNGPHNA------FCNEHMDVSNFLNLH 518
            .:.........:.:|.     |.:.:||            .|||      ||.....::...:.|
Frog   295 HDPNIGNAIHIKVVRLILLEEEEEGLKI------------VHNADQTLASFCKWQKSINPKSDAH 347

  Fly   519 SLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVG-----GQYQSTKRS 578
            ..  |.|  :|.:.|.:|                    ||....:..||:|     |..|.:| |
Frog   348 PA--HHD--VAVLLTRKD--------------------ICASKNSPCETLGLSHLSGMCQPSK-S 387

  Fly   579 LNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHD-YPQECRPGGLNGNYIMFASATSGDRPN 642
            .|      :|.::.:|   ...|:|||:||:||..|| ...:|...|.| .|||.........|
Frog   388 CN------INEDTGLP---LAFTIAHELGHSFGIQHDGQGNDCEIAGRN-PYIMSRQLQYNTSP- 441

  Fly   643 NSKFSPCSIRNISNVLDVLVG------NTKRDCFKASEGAFCGNKIVESGEECDC--GFNEEECK 699
             ..:||||...|:..||...|      ..|:|   ..........:.:...:|..  |.|...|:
Frog   442 -LTWSPCSKEYITRFLDRGWGFCLDDVPAKKD---LKPPIIAPGVLYDVNHQCQLQYGPNATFCE 502

  Fly   700 --DKCCYPRLISEYD---QSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETE 759
              |..|.....|..:   ..|:|:|.|      |:|..|:  .|.:..|..|.|:     .:...
Frog   503 EVDNVCQTLWCSVKNSCRSKLDSAADG------TRCGESK--WCFNGKCINVGTT-----PQTIN 554

  Fly   760 CSW---------SSTCNGTTAECPEPRHRDDKTMCNN-----GTALCIRGE------CSGSPC-- 802
            ..|         |.|| |..||..|.:       |||     |...| .||      |:..||
Frog   555 GGWGAWTPWSHCSRTC-GAGAENAERK-------CNNPQPKFGGKYC-TGERKRYRICNIQPCPK 610

  Fly   803 --LLWNMTKCFLTSTT---------LPHVSKRKLCDLACQ--DGN----------DTSTCRSTSE 844
              ..:...:|...:|.         :|..:....|:|.|:  .||          |.:.|...::
Frog   611 DYPSFREMQCTEFNTVPYKNELYQWIPIYNTENPCELHCRSSSGNFANKFLDAVIDGTPCFERNK 675

  Fly   845 FAD------------KYNIQKG------GISLQPGSPC----------DNFQGYCDVFL------ 875
            ..|            .|.|...      ||.|..||.|          |.| ||.||.|
Frog   676 SRDVCINGICKKVGCDYEIDSNATEDRCGICLGDGSSCQTIKKVFNQTDGF-GYVDVGLIPKGAR 739

  Fly   876 --KCRAVDADGPLLRLKN-----LLLN----------RKTLQTVAEWIVDN-------------- 909
              |...|:..|..|.|::     ..||          .|...|:..:..:|
Frog   740 DIKIEEVEEAGNFLALRSEDPGKYYLNGAYIIQWNGEYKVAGTIFHYQRNNDTENITASGPTNES 804

  Fly   910 -WYLVVLM----GVAFIVVM------------------GSFIKCCAVHTPSSNPKKRRARRISET 951
             |..::..    ||.:..|:                  |.:..|.|  |..:..:.:.:|.:::.
Frog   805 IWIQLLFQEHNPGVRYEYVIQKDVNLENEIESVYTWRYGGWTDCSA--TCGTGVQHQISRCVNKK 867

  Fly   952 LRAPMNTL--RRMQRHPNQRGAGPRSIPP---------------PAHEAQH-----YSRGGDGRG 994
            .....||.  :.||....|:....:..||               |..|.:.     .:.|.|
Frog   868 RGVVKNTFCDQEMQPITRQKKCNTKECPPRWWVGQWQQCSTTCGPTGEKKRTVLCLKTSGSD--- 929

  Fly   995 GGGGGGGRHGGSRSHHQQH----------------PHDWDRHQGGHSIVPLPTGGSHSSRN--SA 1041
                    ....||....|                |.||.  ....|...:..||...:||  .|
Frog   930 --------EEALRSEDCHHLTKPKVYLSCNRDILCPSDWT--VSNWSECSVTCGGGVRTRNITCA 984

  Fly  1042 ANQARRSDGRGPRSTSSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVA 1106
            .|.....|       ||.:|     .|.|..|..:.:
Frog   985 KNNDEPCD-------SSKKP-----NSKALCGLQQCY---------------------------- 1009

  Fly  1107 RAQLPLPLPP--PNGQQQMQQQQQLQLQQPAISPQQQPQQAFYTPKELPPRNKSRSSRTNNTSN- 1168
             .|..||.||  .|.::::.:::           ...|::..:.|        :::.|...|:.
Frog  1010 -VQKTLPKPPIKYNYRKKIIKKK-----------SGDPKRRIFLP--------NKNHRVQTTTGL 1054

  Fly  1169 -----TTTTTNSSTAAAGS 1182
                 :|::||||:.:..|
Frog  1055 PRVFMSTSSTNSSSPSVKS 1073

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	69/309 (22%)
		Reprolysin_2	450..659	CDD:290307	54/237 (23%)
		Disintegrin	684..776	CDD:278623	25/107 (23%)
adamts12	XP_017946319.2	Pep_M12B_propep	65..200	CDD:396235	28/159 (18%)
		ZnMc_ADAMTS_like	258..465	CDD:239801	57/255 (22%)
		ADAM_CR_2	480..544	CDD:407643	15/71 (21%)
		ADAM_CR	527..688	CDD:417715	38/182 (21%)
		TSP1	557..609	CDD:214559	17/60 (28%)
		ADAM_spacer1	714..825	CDD:368694	21/111 (19%)
		TSP1_ADAMTS	840..894	CDD:408800	10/55 (18%)
		TSP1_ADAMTS	898..952	CDD:408800	7/64 (11%)
		TSP1_ADAMTS	960..1008	CDD:408800	15/61 (25%)
		TSP1_ADAMTS	1312..1360	CDD:408800
		TSP1_ADAMTS	1363..1418	CDD:408800
		TSP1_ADAMTS	1421..1467	CDD:408800
		TSP1_ADAMTS	1470..1525	CDD:408800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165165649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930