DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and LOC100360238

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_003751238.2	Gene:	LOC100360238 / 100360238	RGDID:	2322512	Length:	817	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	124/556 - (22%)
Similarity:	186/556 - (33%)	Gaps:	193/556 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 GSGRGREDNKNTCSLYIQTDPLIWRHIRE----GIADHDRGRKYEVDEKTR-EEITSLIAHHVTA 459
            |....|:.:..|..|...:|  :|.|.:.    .:.:|.|.:.:..|..|. :.:..:||    .
  Rat   178 GDSSQRQGSSKTDELLALSD--LWSHAKYVEMFVVVNHQRFQMWGSDVNTTVQAVVDIIA----L 236

  Fly   460 VNYIYRNTKFDGRTEHRNIRFEVQ------RIKIDDDSACRNSYNGPHNAFCNEHM------DVS 512
            .|...|..    .||...:..|:.      .:.:|..:..||     .|.:..|.:      ||:
  Rat   237 ANSFTRGI----NTEVVLVGLEIWTEGDPIEVPVDLQATLRN-----FNLWRQEKLMGRVRHDVA 292

  Fly   513 NFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVASASGASGGICEKYKTYTETVGGQYQSTKR 577
            :.:..|.                  .|...|.|::..|  .|||.....:.:.
  Rat   293 HLIVGHR------------------PGANEGQAFLDGA--CSGGFAAAVEAFH------------ 325

  Fly   578 SLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQ-ECRPGGLNGNYIMFASATSGDRP 641
              :..::.|.            ..:|||:|||.|..||.|. .|.|..|...:.|. |.|||
  Rat   326 --HEDVLLFA------------ALMAHELGHNLGIRHDRPGCTCGPKHLCLMHEMI-SKTSG--- 372

  Fly   642 NNSKFSPCSIRNISNVLDVLVG-----------NTKRDCFKASEGAFCGNKIVESGEECDCGFNE 695
                ||.||..:....|....|           :.:||       |.|||.:||..||||||
  Rat   373 ----FSNCSSDHFLRFLHDHRGACLLDRPWHQSHKRRD-------AHCGNGVVEESEECDCG--- 423

  Fly   696 EEC-KDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEETE 759
            ..| |::||        |:.       |..:...|||...  |||           |.|.|.:..
  Rat   424 NACDKNQCC--------DEK-------CKLKEGAQCSNEL--CCL-----------HCKFKNKGA 460

  Fly   760 --------CSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPCLLWNMTKCF-LT 813
                    |.....||||:|.||..|...|.::|.. :..|..|:|  ..|.|     :..| ..
  Rat   461 VCRPAQGLCDLEEYCNGTSAVCPNDRIAQDGSICQE-SYFCFGGQCRDPSSQC-----SHIFGFG 519

  Fly   814 STTLP-----HVSKRKLCDLACQDGNDTSTCRSTSEFADKYNIQKGGISLQPGS--PCDNFQGYC 871
            |.:.|     .::||         ||....|..:|:              .||:  .|.:....|
  Rat   520 SRSAPDECYTSLNKR---------GNRFGNCGPSSD--------------SPGTYVKCSDQNILC 561

  Fly   872 DVFLKCRAVDADG--PLLRLKNLLLNRKTLQTVAEW 905
            ...: |..|   |  |.::.|::|:.   :..|.:|
  Rat   562 GKLI-CTEV---GYLPPIKDKHMLIQ---IPQVEDW 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	58/295 (20%)
		Reprolysin_2	450..659	CDD:290307	45/221 (20%)
		Disintegrin	684..776	CDD:278623	30/100 (30%)
LOC100360238	XP_003751238.2	Pep_M12B_propep	44..159	CDD:396235
		Reprolysin	203..397	CDD:396140	51/260 (20%)
		DISIN	415..485	CDD:214490	30/100 (30%)
		ACR	489..627	CDD:214743	28/138 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920