Protein Alignment kuz and adam28.2

DIOPT Version :9

• Sequence 1: NP_477187.1
• Gene: kuz / 34772
• FlyBaseID: FBgn0259984
• Length: 1238
• Species: Drosophila melanogaster
• Sequence 2: NP_001120446.1
• Gene: adam28.2 / 100145537
• XenbaseID: XB-GENE-5949648
• Length: 783
• Species: Xenopus tropicalis
• Alignment Length: 928
• Identity: 203/928 - (21%)
• Similarity: 300/928 - (32%)
• Gaps: 332/928 - (35%)

  Fly   200 KTENFIKKIAESTTTSQQLPEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYKESHVE 264
            |||:.|.:            .|||            |:|..|........|:..|  .|.:..||
 Frog    73 KTEDLISE------------HYTE------------TQYLPDGTPIETSPEIQDH--CYYQGGVE 111

  Fly   265 DAYENVREGHVAGC----GITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKSAPQQQQ 325
            :...::..  ::.|    ||          ||......|.||:.:...:.|      ...|.|.|
 Frog   112 NDSSSLLS--ISACSGLSGI----------IQTRGRRYLIEPLKQTDSEEH------AVFPYQAQ 158

  Fly   326 QPHPPKKYISGDEDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDN 390
            :..|   ...|..:..|      .|.||::.:.          :::|.|....|
 Frog   159 ESTP---VTCGVTNTTY------MEGNFSKTSL----------ATSNAAKVEFL----------- 193

  Fly   391 GAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEVDEKTREEITSLIAH 455
                            .:|....||:             :||.....||   .::.|.:...|..
 Frog   194 ----------------KSKKYIELYM-------------VADKSMFNKY---GRSTENVKRRIFE 226

  Fly   456 HVTAVNYIYRN-------------TKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNE 507
            .|..||.:|:.             .|.||.|.   :....:.:|:..|...:|..  |..|
 Frog   227 IVNFVNVVYKQINIFVALTGIEVWDKSDGFTV---VSSADEDLKLFSDWRTKNLL--PRKA---- 282

  Fly   508 HMDVSNFLNLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVAS--ASGASGGICEKYKTYTETVGG 570
                         .|::.|     .|:.||.|.|:|||:|.:  :|.:|.|:.:.:...:..:|.
 Frog   283 -------------HDNAQF-----ITHIDFDGSTVGLAYVGTMCSSTSSTGVIQDHSQQSIAIGA 329

  Fly   571 QYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPHDYPQECRPGGLNGNYIMFASA 635
                                          |:|||:|||.|..||   |.......|:.|| ..|
 Frog   330 ------------------------------TVAHEMGHNLGINHD---EAHCTCSTGSCIM-EPA 360

  Fly   636 TSGDRPNNSKFSPCSIRNISNVLDVLVGNTKRDCFKASE---GAFCGNKIVESGEECDCGFNEEE 697
            .|.:.|.  :||.||.:|..:.:...:....:|..|.:|   ...||||..|.||||||| :..|
 Frog   361 LSFNTPR--EFSLCSHQNYQDFILQKMPLCMKDVPKKTEIQTPPVCGNKFTELGEECDCG-SISE 422

  Fly   698 CKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEET-ECS 761
            |.:.||              :|..|..:|..||  ::|.||  :||.:  |.....|:.:. :|.
 Frog   423 CTNPCC--------------NATTCKLKAGAQC--AEGQCC--DSCKW--TKAGTVCRSKRHDCD 467

  Fly   762 WSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC---SGSPCLLWNMT------KCFLTSTTL 817
            .:..|:|.:||||..|.|.:...|.||...|..|.|   .|....||..:      .||
 Frog   468 LAEMCDGQSAECPSDRFRVNGFPCRNGEGYCYNGLCPTLQGLCSALWGPSSVVADDSCF------ 526

  Fly   818 PHVSKRKLCDLACQD--GNDTSTCR---------------STSEFADKYNIQKGGISLQP----- 860
             :.:.|...:..|||  ||.. .|:               ||......|...:...:|.|
 Frog   527 -NYNLRGANNGYCQDSKGNQV-PCKQSDVKCGVLYCSGGYSTPNLGGYYIRGECKTTLYPTFLVE 589

  Fly   861 -GSPC-DN---FQG----------------------YCDVFLKCRAVDADGPLLRLKNLLLNRKT 898
             |:.| ||   |.|                      .||...:||..:...|
 Frog   590 NGTKCGDNMVCFMGECTSIQTAFGPSDCDAKCPEHAVCDHENQCRCEEGWAP------------- 641

  Fly   899 LQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCCAVHTPSSNPKKRRAR-RISETLRAPMNTLRRM 962
             ...|.:...|..:||   ||.|.|:..||........||..|:|.:| |::..:....|...:.
 Frog   642 -PDCANFTGTNTIIVV---VAIICVIVLFILLFVWFKWSSRRKQRTSRTRVTGAVNPAFNVREKP 702

  Fly   963 QRHPNQRGAGPR---SIP--PPAHEAQHYSRGGDGRGGGGGGGGRHGGSRSHHQQHP---HDWDR 1019
            ........|.|:   ..|  ||...||                     |:.....||   ..|.:
 Frog   703 WGPAGSNAATPQLDSRFPHNPPKPPAQ---------------------SQKPLATHPPTGRSWPQ 746

  Fly  1020 HQGGHSI------VPLPT 1031
            .|.|:.:      .||||
 Frog   747 TQVGYPVRPVNAPPPLPT 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	61/284 (21%)
		Reprolysin_2	450..659	CDD:290307	51/223 (23%)
		Disintegrin	684..776	CDD:278623	31/92 (34%)
adam28.2	NP_001120446.1	Pep_M12B_propep	33..153	CDD:366707	24/123 (20%)
		ZnMc_adamalysin_II_like	197..391	CDD:239797	58/272 (21%)
		Disintegrin	410..482	CDD:365943	31/92 (34%)
		ACR	487..608	CDD:214743	29/128 (23%)
		PHA03247	<677..779	CDD:223021	23/109 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920