DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kuz and adam22

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_021322679.1	Gene:	adam22 / 100126805	ZFINID:	ZDB-GENE-070810-1	Length:	978	Species:	Danio rerio

Alignment Length:	979	Identity:	184/979 - (18%)
Similarity:	282/979 - (28%)	Gaps:	380/979 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 EDFKYPHQKYTKEANFAEGAFYDPSTGRRLGSSANVADWHQLVHERVRRATDNGAGDRGSSGGSG 402
            |||..|       .:.||..|.:|.    |.|:|         |.|.:|....          :.
Zfish   200 EDFISP-------VHLAESLFENPP----LFSAA---------HRRKKRQISR----------NP 234

  Fly   403 RGREDNKNTCSLYIQTDPLIWRHIREGIADHDRGRKYEV---DEKTREEITS---LIAHHVTAVN 461
            |..||......|.:..|.|:::..|..:...:...|..|   |...:|::.:   |:|....|.:
Zfish   235 RSVEDETKYVELMVINDHLMYKKHRLSVGQTNNYAKSVVNMADLYFKEQLNTRIVLVAMETWAAD 299

  Fly   462 YIYRNTKFDGRTEHRNIRFEVQRIKIDDDSACRNSYNGPHNAFCNEHMDVSNFLNLHSLEDHSDF 526
            .                ||.:.    ||.......:......|..|..|     ::|.
Zfish   300 N----------------RFNIN----DDPMVTLREFMKYRRDFIKEKCD-----SVHL------- 332

  Fly   527 CLAYVFTYRDFTGGTLGLAWVASASGAS--GGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNY 589
                      |:|......|    .|||  ||:|      :.|.||           |:..:
Zfish   333 ----------FSGNRFHSNW----GGASYMGGVC------SLTKGG-----------GVNEY--- 363

  Fly   590 NSRVPPKVSQLTLAHEIGHNFGSPHDYPQ----ECR-----PGGLN---GNYIMFASATSGDRPN 642
                 .|...:|||..:|.|.|...|..:    ||:     .|.:.   |.|:
Zfish   364 -----GKEMAITLAQSLGQNIGIFSDKKRILNGECKCEDKWSGCIMDDVGFYL------------ 411

  Fly   643 NSKFSPCSIRNISNVLDVLVGNTKRDCF-----KASEGAFCGNKIVESGEECDCGFNEEECK--- 699
            ..:||.|::....:.|:...|    .|.     |..:...|||..||:||||||| :..||.
Zfish   412 PERFSDCNVEEFHDFLNSGGG----ACLFNKPSKLLDPPECGNGFVEAGEECDCG-SPAECAKEG 471

  Fly   700 DKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQGPCCLSNSCTFVPTSYHQKCKEE-TECSWS 763
            :.||                |.|......:|  |.|.||.:....|:..    .|:|. .:|...
Zfish   472 ENCC----------------KKCMLTQGAKC--SDGLCCKNCQLEFMGV----LCREAVNDCDIP 514

  Fly   764 STCNGTTAECPEPRHRDDKTMCNNGTALCIRGEC--SGSPC-LLWNMTKCFLTSTTLPHVSKRKL 825
            ..|.|.:::||...|:.|...|......|..|.|  ....| .||.              .|...
Zfish   515 EMCTGNSSQCPPNLHKMDGYTCEKDQGRCFNGRCKTKDRQCKYLWG--------------EKATS 565

  Fly   826 CDLACQD------------GNDTST---------------CRSTSEFADKYNIQKGGIS------ 857
            .|..|.:            |.|..|               |.:.|. |.:....:||::
Zfish   566 ADKFCYEKLNIEGTEKGNCGRDKDTWIQCKKQDVHCGYLLCSNISP-APRLGELQGGLTSFSVAQ 629

  Fly   858 ----------------------LQPGSPCD----------------NF--------------QGY 870
                                  ::.|:.|.                ||              .|.
Zfish   630 HSASLDCSGGHVLIDGDTDLGYVEDGTACGTDRICFNHKCLPVQDFNFSTCPGTNERVICSGHGV 694

  Fly   871 CDVFLKC--------RAVDADGPLLRLKNLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSF 927
            |...|:|        ...:|..||    :.||.|.|.:|..         ::...:....:.||.
Zfish   695 CSNELRCVCELGWAGEDCNATSPL----SYLLVRPTAKTSG---------IITTNIIIGAIAGSI 746

  Fly   928 IKCCAVHTPSS-NPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPP------PAHEAQH 985
            :....:...|: ..|..|.|:..|:     :..||.          .|.:||      |......
Zfish   747 LVLALILGISAWGYKTYRQRQYVES-----DVHRRF----------CRPMPPGDYVKKPGDADSL 796

  Fly   986 YSRGGDGRGGGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVP-LPT-------------GGSHS 1036
            ||....|.....|...:...:...|.|        ....|..| :|:             |.|||
Zfish   797 YSDMPQGVSSNSGSSSKKRSAYLSHLQ--------INTCSFTPSIPSISQNISLFGFRSNGLSHS 853

  Fly  1037 SRNSAANQARRSDGRGPRSTSSGRPQAIASGSGAASGA----------ARSHGGYGAEQAIP--- 1088
            ......:....||     ...:|||:: .|..|..:|.          |||:   ..|...|
Zfish   854 WSERIPDAKHISD-----VCENGRPRS-NSWQGNITGTRKKLKGKKFRARSN---STEYLTPCVK 909

  Fly  1089 ---------------------GSIGGGVQAAISSGGVVARAQLPLPLPPPNGQQQMQQQQQLQLQ 1132
                                 .::........|:|.:.:..:.|.|:||...:::...:|..:|.
Zfish   910 SEYYVTKWVEDVNKNTEGPYIRTLSPAKSPTSSTGSIASSRRYPYPMPPLPDEERKANRQSARLW 974

  Fly  1133 QPAI 1136
            :.:|
Zfish   975 ETSI 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	52/291 (18%)
		Reprolysin_2	450..659	CDD:290307	40/225 (18%)
		Disintegrin	684..776	CDD:278623	27/95 (28%)
adam22	XP_021322679.1	Pep_M12B_propep	74..191	CDD:307618
		Reprolysin	242..439	CDD:330960	51/283 (18%)
		Disintegrin	454..527	CDD:306668	27/95 (28%)
		ACR	531..672	CDD:214743	21/155 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920