DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kuz and adam8b

DIOPT Version :9

Sequence 1:	NP_477187.1	Gene:	kuz / 34772	FlyBaseID:	FBgn0259984	Length:	1238	Species:	Drosophila melanogaster
Sequence 2:	XP_003199621.2	Gene:	adam8b / 100005593	ZFINID:	ZDB-GENE-070808-1	Length:	819	Species:	Danio rerio

Alignment Length:	1070	Identity:	211/1070 - (19%)
Similarity:	307/1070 - (28%)	Gaps:	441/1070 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 IAESTTTSQQL-------PEYTESSSSSTTTFPPTTEYFEDEKERNAEDELDFHSIIYK-----E 260
            :|||..|...:       |:....|...:...||:.|.:.|.             :.||     |
Zfish    20 VAESIRTLPHVERFDVVRPKRLNLSKVQSDKNPPSHEKYPDR-------------LAYKLFFEGE 71

  Fly   261 SHVEDAYENVREGHVAGCGITDEVSQWMENIQNSAVEELPEPMSKDYQKLHRKQLHKKS------ 319
            :||....:|.:   :.|...|:...|    ...|.|...|......|...|.:.:...|
Zfish    72 NHVIHLEKNKQ---LVGHNYTEIYYQ----DDGSIVSRNPSFKDNCYYHGHIQDMEYSSVSVGIC 129

  Fly   320 --------APQQQQQPHPPKKYISGDEDFKYPHQKYTKEANFA---EGAFYD--PSTGRRLGSSA 371
                    ..||.....|...:..||... |.||...:..:.|   :..|||  |.....|.||.
Zfish   130 SGIRGFVRVKQQVYLIEPLANHSDGDHAL-YKHQHLRRRRSSAGEPKTMFYDHEPQVSAALKSSR 193

  Fly   372 NVADWHQLVHERVRRATDNGAGDRGSSGGSGRGREDNKNTCSLYIQTDPLIWRHIREGIADHDRG 436
                |:....:..|                         ...|::..|...:|:....: |..|.
Zfish   194 ----WNMKSFQTPR-------------------------FVELFLVVDNTEYRNFGSSM-DSIRA 228

  Fly   437 RKYEVDEKTREEITSLIAHHVTAVNYIYRNTKFDGRTEHRNIRFEVQRIKI------------DD 489
            |..||               |..|:.:||:.         |||..:..:::            .|
Zfish   229 RMLEV---------------VNHVDKLYRSL---------NIRVMLVGLEVWMKQDQIVVSVSSD 269

  Fly   490 DSACRNSYNGPHNAFCNEHMDVSNFL-----NLHSLEDHSDFCLAYVFTYRDFTGGTLGLAWVAS 549
            |:                   :|.|:     ||.....|.:   |...|..||.|.|:|||
Zfish   270 DT-------------------LSRFIEWRKSNLLKRVKHDN---AQFVTGIDFLGDTVGLA---- 308

  Fly   550 ASGASGGICEKYKTYTETVGGQYQSTKRSLNTGIITFVNYNSRVPPKVSQLTLAHEIGHNFGSPH 614
                     .|:....|:..|                ||.:....|.....|:|||:|||.|..|
Zfish   309 ---------NKFAMCAESSAG----------------VNQDHNQNPLGLASTIAHEMGHNMGMSH 348

  Fly   615 DYPQECRPGGLNGNYIMFASATSGDRPNN---SKFSPCSIRNISNVLDVLVGNTKRDC------- 669
            | ...|    ..|:.::.:.....:|...   .:||.||:..::..||    |....|
Zfish   349 D-EDHC----TCGSSVISSFCIMTERVGTLFPEQFSDCSLEQLTVFLD----NANPSCLLDTPSS 404

  Fly   670 FKASEGAFCGNKIVESGEECDCGFNEEECKDKCCYPRLISEYDQSLNSSAKGCTRRAKTQCSPSQ 734
            :|...|..|||..::.||||||| :.||||:.||.|..              |.....::|  :|
Zfish   405 YKLYSGPVCGNAFLDPGEECDCG-SVEECKNPCCDPMT--------------CKLTEGSRC--AQ 452

  Fly   735 GPCCLSNSCTFVPTSYHQKCKEE-TECSWSSTCNGTTAECPEPRHRDDKTMCNNGTALCIRGECS 798
            |.||  .:|..  ......|:.. .||.....|.|.:.:|||...|.:...|::|...|..|:|.
Zfish   453 GDCC--ENCQI--KDAESLCRASINECDVPEYCTGLSEKCPENDFRMNGIPCSSGQGYCYNGQCP 513

  Fly   799 G--SPC-LLWNM------TKCFLTST---TLPHVSKRK-----------LC-DLACQDGND---- 835
            .  ..| .||..      ..||..:|   ...|..|.|           .| .:.|.:||:
Zfish   514 THLQHCQRLWGTGAKVAPDTCFYQNTLGKNDSHCGKTKDGIRPCARENMFCGKIFCNEGNEFPVT 578

  Fly   836 -----TSTCRSTSEFADKYNIQKGGISLQP-GSPCD--------------------------NFQ 868
                 ..|.|.....|.. ..::..:|:.| |:.|.                          |.:
Zfish   579 GQKAVIVTLRGQCNVAGD-QTEEDALSMVPTGTKCGHNKVCYDYKCQELNIYGSIEGCSLQCNGR 642

  Fly   869 GYCDVFLKCRAVDA-DGPLLRLK-NLLLNRKTLQTVAEWIVDNWYLVVLMGVAFIVVMGSFIKCC 931
            |.|:...:|..... ..|...:| :.|.:.||:.           :.|.:.||.:||:     |.
Zfish   643 GICNHKKQCHCDPGWAPPYCNVKYSELSSAKTIG-----------ISVAVAVAVLVVI-----CG 691

  Fly   932 AV--HTPSSNPKKRRARRISETLRAPMNTLRRMQRHPNQRGAGPRSIPPPAHEAQHYSRGGDGRG 994
            ||  |      |||:|                :.||..|
Zfish   692 AVLYH------KKRKA----------------ISRHKTQ-------------------------- 708

  Fly   995 GGGGGGGRHGGSRSHHQQHPHDWDRHQGGHSIVPLPTGGSHS---SRNSAANQARRSDGRGPRST 1056
                                              .||.|..|   ..|||
Zfish   709 ----------------------------------TPTSGQTSLLFENNSA--------------- 724

  Fly  1057 SSGRPQAIASGSGAASGAARSHGGYGAEQAIPGSIGGGVQAAISSGGVVARAQLPL--------- 1112
            ...||:                                :...|..|..|::...||
Zfish   725 QKDRPE--------------------------------ISQPIFMGTTVSQPCTPLTARVGPTRP 757

  Fly  1113 -PLP---PPNGQQQMQQQQQLQLQQPAISP 1138
             |||   ||:..||....|..:|..|.:.|
Zfish   758 APLPPKKPPSQPQQTTVTQGTKLPAPPVPP 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kuz	NP_477187.1	ZnMc_TACE_like	410..677	CDD:239798	60/293 (20%)
		Reprolysin_2	450..659	CDD:290307	46/228 (20%)
		Disintegrin	684..776	CDD:278623	28/92 (30%)
adam8b	XP_003199621.2	Pep_M12B_propep	51..164	CDD:279848	27/133 (20%)
		Reprolysin	203..402	CDD:279729	59/308 (19%)
		ZnMc_adamalysin_II_like	203..400	CDD:239797	59/306 (19%)
		DISIN	419..491	CDD:214490	28/92 (30%)
		ACR	495..626	CDD:214743	25/131 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920