Protein Alignment Hsp60D and CCT2

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_012124.1
• Gene: CCT2 / 854664
• SGDID: S000001404
• Length: 527
• Species: Saccharomyces cerevisiae
• Alignment Length: 578
• Identity: 131/578 - (22%)
• Similarity: 225/578 - (38%)
• Gaps: 141/578 - (24%)

  Fly    26 ARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP-RITKDGITVANNVQLGNRRQDMGVQLLR 89
            ||.....|...:.:.|.:||||||.:.|::....:. .:|.||.|:..::.|.|    ...::|.
Yeast    18 ARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDN----PAAKVLV 78

  Fly    90 QATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGILEGSRAVCDALGE------ 148
            ..:...:::||||||:.|:|:..:..:...::.|||::.|.:.||....|.|..|||.:
Yeast    79 NISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNS 143

  Fly   149 ----------------------MSQSVDTIGQVEAVAKVALNGDERLAELIGDIILELG------ 185
                                  :||..|...::...|.:.|.|...|..:  .||..||
Yeast   144 HDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKGSTNLEHI--QIIKILGGKLSDS 206

  Fly   186 --DSGVILLKE--SHSP--FDEAKIQEGITIASGYYSPFFAKQSHTLELENCLLLLTLAKIDQVE 244
              |.|.||.|:  ::.|  .:.|||....|               ||:.:...:..|..|:|...
Yeast   207 FLDEGFILAKKFGNNQPKRIENAKILIANT---------------TLDTDKVKIFGTKFKVDSTA 256

  Fly   245 QI--LPALELARLKERPLLIIAK--NFGSDLLKILVLNNLQGRVQVCAVKAPSFGD--------E 297
            ::  |...|..::|.:    |||  .||        :|....|..:.......|.|        .
Yeast   257 KLAQLEKAEREKMKNK----IAKISKFG--------INTFINRQLIYDYPEQLFTDLGINSIEHA 309

  Fly   298 QCEEMEDIAFATGGHLLEDASSLADLSEEDLGE--VMEAVVDAKETHLLQPINVNEEQVQCRIQD 360
            ..|.:|.:|..|||   |..|:..:.|:..|||  |:|.::..::..|
Yeast   310 DFEGVERLALVTGG---EVVSTFDEPSKCKLGECDVIEEIMLGEQPFL----------------- 354

  Fly   361 IRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISD-GVV 424
                   .|:           |...|...||.:.|.::..:.|.:...:|||..:.....: ..|
Yeast   355 -------KFS-----------GCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTV 401

  Fly   425 PGGGTAYLRCIPVLDELPPTDIMELQVGREIVKDAL-----RLPCYTIARNAGVDPNEVLRR--- 481
            .|||.|.:    |:.:...|:...:...:.:..:|.     :||. .:|.|||.|.:|::.:
Yeast   402 LGGGCAEM----VMSKAVDTEAQNIDGKKSLAVEAFARALRQLPT-ILADNAGFDSSELVSKLRS 461

  Fly   482 -VLKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLATTEVLITKQP 538
             :..|....|.|...|...|:...|||:..|:.::.::||:..|.:|...:.:|..:|
Yeast   462 SIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARP 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	130/574 (23%)
CCT2	NP_012124.1	TCP1_beta	5..520	CDD:239452	131/578 (23%)