DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and CCT6

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_010474.3	Gene:	CCT6 / 851768	SGDID:	S000002596	Length:	546	Species:	Saccharomyces cerevisiae

Alignment Length:	589	Identity:	142/589 - (24%)
Similarity:	237/589 - (40%)	Gaps:	140/589 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VNV-----LANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGNRRQDMGVQLLRQATN 93
            |||     |.:.:.|.|||||...::.....:.::||||..:...:|:    |.....|:.:|..
Yeast    21 VNVTSAEGLQSVLETNLGPKGTLKMLVDGAGNIKLTKDGKVLLTEMQI----QSPTAVLIARAAA 81

  Fly    94 NTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGILEGSRAVCDALGE-------MSQ 151
            ..:...||||||...|. |...:..|...|..|:.:::.:|.....:.....|.|       :|.
Yeast    82 AQDEITGDGTTTVVCLV-GELLRQAHRFIQEGVHPRIITDGFEIARKESMKFLDEFKISKTNLSN 145

  Fly   152 SVDTIGQV---EAVAKVALNGDERLAELIGDIILELGDSG--------VILLKESH-SPFDEAKI 204
            ..:.:.||   ..:.||..:..|.|..::.|.:|.:.|:.        |.:::..| ||.|...|
Yeast   146 DREFLLQVARSSLLTKVDADLTEVLTPIVTDAVLSVYDAQADNLDLHMVEIMQMQHLSPKDTTFI 210

  Fly   205 QEGITIASGYYSPFF---AKQSHTLELENCLLLLTL-------------AKIDQVEQILPALEL- 252
             :|:.:..|...|..   .|.::.|     :|.::|             :..||.:: |.|.|.
Yeast   211 -KGLVLDHGGRHPDMPTRVKNAYVL-----ILNVSLEYEKTEVNSGFFYSSADQRDK-LAASERK 268

  Fly   253 ---ARLKERPLLIIAKN--FGSDLLKILVLNNLQG----------RVQVCAVKAPSFGDEQCEEM 302
               |:||:   :|..||  .|.|..|..|:.|.:|          :..:.|::.     .:...|
Yeast   269 FVDAKLKK---IIDLKNEVCGMDPDKGFVIINQKGIDPMSLDVFAKHNILALRR-----AKRRNM 325

  Fly   303 EDIAFATGGHLLEDASSLADLSEEDLG----EVMEAVVDAKETHLLQPINVNEEQVQCRIQDIRE 363
            |.:...|||   |..:|:.|||.:.||    ...|.:.:.|.|::.:    |.:...|
Yeast   326 ERLQLVTGG---EAQNSVEDLSPQILGFSGLVYQETIGEEKFTYVTE----NTDPKSC------- 376

  Fly   364 LIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISD-GVVPGG 427
                                      ||.:.|::...:::.||...|.|.||...:.| .::||.
Yeast   377 --------------------------TILIKGSTHYALAQTKDAVRDGLRAVANVLKDKNIIPGA 415

  Fly   428 GTAYLRCIPVLDELPPTDIMEL------QVGREIVKDALRLPCYTIARNAGVDPNEVLRRV---- 482
            |..|   |.:...|...::.:|      :.|.|...:||.:...|:.:|:|.||.:||..|
Yeast   416 GAFY---IALSRYLRSANMNKLGAKGKTKTGIEAFAEALLVIPKTLVKNSGFDPLDVLAMVEDEL 477

  Fly   483 --LKGSGN---YGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIAS-LLATTEVLITKQPTKP 541
              .:.|..   .|.|...|:..|..:.||.|..:||::|:|.|.|||| ||...|:|...:.|..
Yeast   478 DDAQDSDETRYVGVDLNIGDSCDPTIEGIWDSYRVLRNAITGATGIASNLLLCDELLRAGRSTLK 542

  Fly   542 KIPK 545
            :.|:
Yeast   543 ETPQ 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	142/589 (24%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	140/578 (24%)
CCT6	NP_010474.3	chap_CCT_zeta	2..542	CDD:274088	141/583 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810