DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and HSP60

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_189041.1	Gene:	HSP60 / 821983	AraportID:	AT3G23990	Length:	577	Species:	Arabidopsis thaliana

Alignment Length:	529	Identity:	200/529 - (37%)
Similarity:	331/529 - (62%)	Gaps:	12/529 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ANDIRFGAEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGNRRQ 81
            |.:|:||.|||.|:::||..||:||..|:|||||||:|||...:|::||||:|||.:::..::.:
plant    33 AKEIKFGVEARALMLKGVEDLADAVKVTMGPKGRNVVIEQSWGAPKVTKDGVTVAKSIEFKDKIK 97

  Fly    82 DMGVQLLRQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGILEGSRAVCDAL 146
            ::|..|::|..|.||:..|||||.||:|.|.|..:|...: .:.:|...||.||.....||...|
plant    98 NVGASLVKQVANATNDVAGDGTTCATVLTRAIFAEGCKSV-AAGMNAMDLRRGISMAVDAVVTNL 161

  Fly   147 GEMSQSVDTIGQVEAVAKVALNGDERLAELIGDIILELGDSGVILLKESHSPFDEAKIQEGITIA 211
            ...::.:.|..::..|..::.||:..:.|||...:.::|..|||.:::..:.|:|.::.||:.:.
plant   162 KSKARMISTSEEIAQVGTISANGEREIGELIAKAMEKVGKEGVITIQDGKTLFNELEVVEGMKLD 226

  Fly   212 SGYYSPFFAKQSHT--LELENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKI 274
            .||.||:|.....|  .||::.|:|:...||..:..|:..||||..::|||||::::..||.|..
plant   227 RGYTSPYFITNQKTQKCELDDPLILIHEKKISSINSIVKVLELALKRQRPLLIVSEDVESDALAT 291

  Fly   275 LVLNNLQGRVQVCAVKAPSFGDEQCEEMEDIAFATGGHLLEDASSL----ADLSEEDLGEVMEAV 335
            |:||.|:..::|||:|||.||:.:...::|:|..|||.::.|...:    .|||.  ||...:..
plant   292 LILNKLRAGIKVCAIKAPGFGENRKANLQDLAALTGGEVITDELGMNLEKVDLSM--LGTCKKVT 354

  Fly   336 VDAKETHLLQPINVNEEQVQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELE 400
            |...:|.:|.... :::.::.|.:.||..|:.:.:|.:.::|:.||.:|.|.:|.:.:||.||.|
plant   355 VSKDDTVILDGAG-DKKGIEERCEQIRSAIELSTSDYDKEKLQERLAKLSGGVAVLKIGGASEAE 418

  Fly   401 VSERKDRFNDALHAVRVAISDGVVPGGGTAYLRCIPVLDELPPTDIMELQVGREIVKDALRLPCY 465
            |.|:|||..|||:|.:.|:.:|::||||.|.|.....|::| ||...:.::|.:|:::||:.|.|
plant   419 VGEKKDRVTDALNATKAAVEEGILPGGGVALLYAARELEKL-PTANFDQKIGVQIIQNALKTPVY 482

  Fly   466 TIARNAGVDPNEVLRRVL-KGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLAT 529
            |||.||||:...::.::| :.:.:.|||||.||:.|:|..||:||.||:::|:..||.::|||.|
plant   483 TIASNAGVEGAVIVGKLLEQDNPDLGYDAAKGEYVDMVKAGIIDPLKVIRTALVDAASVSSLLTT 547

  Fly   530 TEVLITKQP 538
            ||.::...|
plant   548 TEAVVVDLP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	200/529 (38%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	198/524 (38%)
HSP60	NP_189041.1	GroEL	34..554	CDD:239460	198/524 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D415781at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45633
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880