Protein Alignment Hsp60D and MKKS

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_061336.1
• Gene: MKKS / 8195
• HGNCID: 7108
• Length: 570
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 92/493 - (18%)
• Similarity: 167/493 - (33%)
• Gaps: 173/493 - (35%)

  Fly    34 VNVLANAVATTLGPKGR------------------NVLIEQLLISPRITKD-------------- 66
            ::||...|.:..||.||                  :.|:..||::..|.|.
Human    26 LSVLKRIVTSCYGPSGRLKQLHNGFGGYVCTTSQSSALLSHLLVTHPILKILTASIQNHVSSFSD 90

  Fly    67 -------------------GITVANNVQLGNRRQDMGVQLLRQATNNTNNKVGDGTTTATI-LAR 111
                               |:|....::|......:.:..|:..|......|...:|...: |.|
Human    91 CGLFTAILCCNLIENVQRLGLTPTTVIRLNKHLLSLCISYLKSETCGCRIPVDFSSTQILLCLVR 155

  Fly   112 GI-----ACQGMHVLRQSKVNVQLLREGILEGSRAVCDALGEMSQSVDTIGQVEAVAKVALNGDE 171
            .|     ||.   :.|:...:|..|   ||   ||....:.|.::....:|:   ...|.|.|..
Human   156 SILTSKPACM---LTRKETEHVSAL---IL---RAFLLTIPENAEGHIILGK---SLIVPLKGQR 208

  Fly   172 RL-AELIGDIILELGDSGVILL---KESHS----------PFDEAKIQEGITIASGYYSPFFAKQ 222
            .: :.::..|::|:.:..::.|   |:|.:          ..|.:...||..:.
Human   209 VIDSTVLPGILIEMSEVQLMRLLPIKKSTALKVALFCTTLSGDTSDTGEGTVVV----------- 262

  Fly   223 SHTLELENCLL--LLTLAK---IDQVEQIL------PALELARLKERPLLIIAKNFGSDLLKILV 276
            |:.:.|||.:|  ||.|.:   .|.|:.:|      |:|:......|  :|.....|..|::.|.
Human   263 SYGVSLENAVLDQLLNLGRQLISDHVDLVLCQKVIHPSLKQFLNMHR--IIAIDRIGVTLMEPLT 325

  Fly   277 -LNNLQGRVQVCAVKAPSFGDEQCEEMEDIAFATGG-----HLLEDASSLADL---SEEDLG--- 329
             :...|....:.::...|:|     .::|:..|..|     ||:.:.:::..|   :..|..
Human   326 KMTGTQPIGSLGSICPNSYG-----SVKDVCTAKFGSKHFFHLIPNEATICSLLLCNRNDTAWDE 385

  Fly   330 ---------EVMEAVV---------DAKETHLL-----------QPINVNEEQVQCRIQDIRELI 365
                     .|::..:         ...||||.           :.|..::|..|..:|    ||
Human   386 LKLTCQTALHVLQLTLKEPWALLGGGCTETHLAAYIRHKTHNDPESILKDDECTQTELQ----LI 446

  Fly   366 DEAFTDVELDRLKTRLGRLQ------------GHLATI 391
            .|||...    |::.:|.|:            |||.::
Human   447 AEAFCSA----LESVVGSLEHDGGEILTDMKYGHLWSV 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	92/493 (19%)
MKKS	NP_061336.1	Cpn60_TCP1	29..569	CDD:395068	91/490 (19%)
		Substrate-binding apical domain	198..370		37/192 (19%)