Protein Alignment Hsp60D and CCT3

DIOPT Version :9

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_005989.3
• Gene: CCT3 / 7203
• HGNCID: 1616
• Length: 545
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 110/575 - (19%)
• Similarity: 211/575 - (36%)
• Gaps: 137/575 - (23%)

  Fly    31 MQGVNVLANAVATTLGPKGRNVLIEQLLISPR----ITKDGITVANNVQLGNRRQDMGVQLLRQA 91
            :.....:|:.:.|.||||.    :.::|:.|.    :|.||..:...:|:    |....:.:.:.
Human    27 INAAKTIADIIRTCLGPKS----MMKMLLDPMGGIVMTNDGNAILREIQV----QHPAAKSMIEI 83

  Fly    92 TNNTNNKVGDGTTTATILARGIACQGMHVLRQSK------------------------------- 125
            :...:.:||||||:..|||..:.....|.|.|..
Human    84 SRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISD 148

  Fly   126 -------VNVQLLREGILEGSRAVCDALGEMSQSVDTIGQVE----AVAKVALNGDERLAELIGD 179
                   :|..:..:.|...|...|:.      ::|.:..|:    ...::.:....|:.::.|.
Human   149 SDMMLNIINSSITTKAISRWSSLACNI------ALDAVKMVQFEENGRKEIDIKKYARVEKIPGG 207

  Fly   180 IILELGDS----GVILLKESHSPFDEAKIQEGITIASGYYSPFFAKQSHT-LEL---ENCLLLLT 236
            ||   .||    ||::.|:...|.....|:....:.......:...:|.| :|:   |:...:|.
Human   208 II---EDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQ 269

  Fly   237 LAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPSFGDEQCEE 301
            :.: :.::|:..  ::.:||  |.::|.:...|||.:..::     |..:.|::.....|.
Human   270 MEE-EYIQQLCE--DIIQLK--PDVVITEKGISDLAQHYLM-----RANITAIRRVRKTDN---- 320

  Fly   302 MEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQVQCRIQDIRELID 366
             ..||.|.|..::   |...:|.|:|:|                        ....:.:|:::.|
Human   321 -NRIARACGARIV---SRPEELREDDVG------------------------TGAGLLEIKKIGD 357

  Fly   367 EAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVR-VAISDGVVPGGGTA 430
            |.||.:...:        .....||.:.|.|:..:||.:....||:...| |.:...:|||||.:
Human   358 EYFTFITDCK--------DPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGAS 414

  Fly   431 YLRCIPVLDELPPTDIMELQVGRE-----IVKDALRLPCYTIARNAGVDPNEVL-----RRVLKG 485
            .:.....|     |:..:...|.|     .|..||.:...|:.:|.|.....:|     :...:.
Human   415 EMAVAHAL-----TEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQEN 474

  Fly   486 SGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLATTEVLITKQPTK 540
            ...:|.:...|...|:...||.:|..|......:|...|.||...:.:::....|
Human   475 CETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKK 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	110/575 (19%)
		GroEL	18..536	CDD:239460	109/569 (19%)
CCT3	NP_005989.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		chap_CCT_gamma	6..529	CDD:274085	109/573 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..545		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900