Protein Alignment Hsp60D and Mkks

DIOPT Version :9

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_001135418.1
• Gene: Mkks / 59030
• MGIID: 1891836
• Length: 570
• Species: Mus musculus
• Alignment Length: 641
• Identity: 120/641 - (18%)
• Similarity: 202/641 - (31%)
• Gaps: 225/641 - (35%)

  Fly    34 VNVLANAVATTLGPKGRNVLIEQLLISPRITKDGI--TVANNVQLGNRRQDMGV--QLLRQATNN 94
            ::||...:|:..||.||   ::||       .:|:  .|....|.....:::.|  .:|:..|::
Mouse    26 LSVLKGVIASCYGPSGR---LKQL-------HNGLGGCVYTTSQSSALLRNLSVTHPVLKILTSS 80

  Fly    95 TNNKVG----DGTTTATI---LARGIACQGMHVLRQSKVNVQLLR--EGILEGSRAVCDALGEMS 150
            ..|.|.    .|..||.:   |...|....:......|:|..||.  ...|:.....|....:..
Mouse    81 VQNHVSCFSDCGLFTAILCCNLIENIQRLDLTPATAIKLNKYLLSLCTSYLKSEACSCRIPVDFR 145

  Fly   151 QSVDTIGQVEAV--AKVALNGDERLAELIGDIILE---------------LGDSGVILLKESHSP 198
            .:...:..|.::  :|.|.....:..:.||.:||:               ||.|.::.||...
Mouse   146 STHTFLSLVHSILTSKPACMLTRKETDHIGALILKAFLLTIPESTEERMVLGKSIIVPLKGQR-- 208

  Fly   199 FDEAKIQEGITI---------------ASGYYSPFFAKQ---------------SHTLELENCLL 233
            ..::.:..|:.|               |||.....|...               .:.:.|||.:|
Mouse   209 VTDSTVLPGLLIEASEVQLRRLLPTQKASGLRVALFCTSLSGDFSNAGEGVVVAHYQVSLENAVL 273

  Fly   234 --LLTLAK---IDQVEQIL------PALELARLKERPLLIIAKNFGSDLLKILVLNNLQGRVQVC 287
              ||.|.:   .|.|:.:|      |:|: ....||.::.|                  .||.|.
Mouse   274 EQLLNLGRRLVTDHVDLVLCQKVIHPSLK-QFFSERHVMAI------------------DRVGVT 319

  Fly   288 AVKAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEE 352
            .             ||.::..||...:...:.:...:...:.:|..|...:|....|.|   ||.
Mouse   320 L-------------MESLSKVTGATPIGSLNPIVSTTYGSVKDVCSARFGSKHFFHLLP---NEA 368

  Fly   353 QVQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRV 417
            .|                                  .|:.:...::....|.|.....|:|.:::
Mouse   369 TV----------------------------------CTLLLCSRNDTAWEELKLTCQTAMHVLQL 399

  Fly   418 AISD-GVVPGGG------TAYLR---------------CIPVLDELPPTDIMELQVGREIVKDAL 460
            .|.: .|:.|||      .||:|               |...          :|.|..|....||
Mouse   400 TIKEPWVLLGGGCTETHLAAYVRHKVHHEAEAIVRDDGCTQA----------KLHVAAEAFCSAL 454

  Fly   461 RLPCYTIARNAGVDPNEVLRRVLKGSGNYGY-------DAAAGEFGDLVVR---GIVDPTKVL-- 513
            .    ::|.:...|..|:|.     ...||:       .|:.|.:.|.:.|   |:.:..:.|
Mouse   455 E----SVAGSLEHDGGEILI-----DTKYGHLWSCQADSASVGNWSDTLSRCGCGLYNSQEELSW 510

  Fly   514 ------------QSAMTSAA-GIASLLATTEVLITKQPTKPKIPKNQVTKDLAKLV 556
                        |:.:..|| |.||.|       |......|:...||..:.|.|:
Mouse   511 SVLRSTYHPFAPQTCLPQAALGSASNL-------TVDCFTAKLSGLQVAVETANLI 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	116/629 (18%)
		GroEL	18..536	CDD:239460	114/619 (18%)
Mkks	NP_001135418.1	Cpn60_TCP1	29..569	CDD:395068	119/638 (19%)
		Substrate-binding apical domain. /evidence=ECO:0000250|UniProtKB:Q9NPJ1	198..370		38/208 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900