DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hsp60D and Bbs10

DIOPT Version :9

Sequence 1:NP_609656.1 Gene:Hsp60D / 34763 FlyBaseID:FBgn0032525 Length:558 Species:Drosophila melanogaster
Sequence 2:NP_001102756.1 Gene:Bbs10 / 500832 RGDID:1560748 Length:713 Species:Rattus norvegicus


Alignment Length:574 Identity:103/574 - (17%)
Similarity:183/574 - (31%) Gaps:201/574 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 VLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGNRRQDMGVQLLRQATNNTNNKVG 100
            ||.......:||:|..||..:......:::||..:...:.|    :....:::....::...|.|
  Rat    16 VLETIANRCVGPEGGLVLCTKPTGEVLLSRDGGCLLEALHL----EHPLARMIVACVSSHLKKTG 76

  Fly   101 DGTTTATI----LARGI-------------------------ACQGMHVLR-----QSK-----V 126
            ||..|..|    |.||:                         .||...:.|     |::     |
  Rat    77 DGAKTFIIFLCHLLRGLHAIGEKEKDSFTSEDIQSHERHWKNCCQWKSISRALLRFQTQTLGCIV 141

  Fly   127 NVQLLREGI------LEGSRAVCDALGEMSQSVDTIGQVEAVAKVALNGDERLAELIGDII---- 181
            :..|.|..:      .|| |.:|      .:|::.:.:.....:|..|....:::|:.|.:    
  Rat   142 DQHLSRHYLSAFSSSAEG-RTLC------RRSLELLLEPYFCGRVGRNNHRFISQLMCDYVFKCM 199

  Fly   182 ------------------LELGDSGVILLKESHSPFDEAKIQEGITIASGY--YSPFFAKQSHTL 226
                              |.:|.:|:        |..|::|.:|:.:...:  |.|........:
  Rat   200 ACESGIEVFEFLDNCFVELNVGVTGL--------PVSESRIVDGLVLPRDFSVYCPADGGIRMVI 256

  Fly   227 ELENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLNNLQG---RVQVCA 288
            ..|   :|..|......|.:|.:....:..:..::...|.         |:|:|:.   ::.:.:
  Rat   257 VTE---ILQPLFSSSSSEFVLDSETQFQASQSWIMDRTKT---------VMNHLRSHNVKLLLSS 309

  Fly   289 VKAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQ 353
            ||.|.. ...|..:..|            |.:..||.|::..|.....       |.|..:.|..
  Rat   310 VKQPDL-VTYCARLNSI------------SVVECLSSEEVSLVQRITG-------LSPCVLPELA 354

  Fly   354 VQCRIQD------IRELIDEAFTDVELDRLKTRLGRLQGHLATI----FV-------GGTSELEV 401
            .||.|.|      .:.||             .|.|| ..||..:    ||       |....| |
  Rat   355 SQCHIADSALVRFCKPLI-------------VRSGR-YAHLGLVSTCAFVPHCVVLCGPVLGL-V 404

  Fly   402 SERKDRFNDALHAVRVAISDGVVPGGGTAYLRCI----------PVLD-------ELPPT----- 444
            .:.:..|:.|...:|...:|        ..|.|:          |:.|       ..|.|     
  Rat   405 QQHESAFHGAFKMLRQLFTD--------LDLNCMIQTKERRNPSPLADSSNRESSHSPKTGKYQD 461

  Fly   445 ------DIMELQVGREI-----VKDALRLPC--YTIARNAGVDP---NEVLRRV 482
                  |.:|.|...|:     ..|...:.|  ::..:...:||   ||:.:|:
  Rat   462 VVAKNKDKLETQTRLEVYPRLGASDTELITCKLWSAHKETSIDPSQTNEIPKRL 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp60DNP_609656.1 PTZ00114 13..546 CDD:185455 103/574 (18%)
GroEL 18..536 CDD:239460 103/574 (18%)
Bbs10NP_001102756.1 chaperonin_like 7..>94 CDD:295468 19/81 (23%)
Cpn60_TCP1 13..>424 CDD:278544 85/473 (18%)
Glyco_tranf_GTA_type <589..>673 CDD:299700
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0459
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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