DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60D and cct2

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001006757.1	Gene:	cct2 / 448434	XenbaseID:	XB-GENE-1006535	Length:	535	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	126/586 - (21%)
Similarity:	232/586 - (39%)	Gaps:	124/586 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NDIRFGAE------ARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP------RITKDGITV 70
            |..:.||:      ||.....|...:.:.|.:||||||    ::::|:|.      .:|.||.|:
Frog    10 NIFKAGADEEKAETARLSSFIGAIAIGDLVKSTLGPKG----MDKILLSSGRDSTVTVTNDGATI 70

  Fly    71 ANNVQLGNRRQDMGVQLLRQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGI 135
            ...:.:.|    ...|:|...:...:::||||||:.|:||..:..:. .||...|::.|.:..|.
Frog    71 LKAIGIDN----PAAQVLVDMSKVQDDEVGDGTTSVTVLAAELLREA-EVLVARKIHPQTIISGW 130

  Fly   136 LEGSRAVCDALGEMSQSVD-------------TIGQVEAVAKVALNGDERLAELIGDIILELGDS 187
            .:.::...:||  ::.|||             .|.:....:|:..:..:..::|..:.:|.|..|
Frog   131 RQATQVAREAL--LNASVDHGNDEEKFRCDLLNIARTTLSSKLLTHHKDHFSKLAVEAVLRLKGS 193

  Fly   188 G----VILLKESHSPFDEAKIQEGITIAS--GYYSPFFAKQSHTLELENCLLLL----------- 235
            |    :.::|:......|:.:.||..:..  |...|        ..:||..:|:
Frog   194 GNLEAIHVIKKLGGSLTESYLDEGFLLDKKIGVNQP--------KRIENAKILIANTGMDTDKIK 250

  Fly   236 ---------TLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLN---NLQGRVQVCA 288
                     :.||:.::|    ..|..::||:...|:.......:.:.|:.|   .|.....|.|
Frog   251 IFGSRVRVDSTAKVAEIE----LAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFATAGVMA 311

  Fly   289 VKAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQ 353
            ::...|..     :|.:|..|||.:    :|..|..|         :|......|::.:.:.|
Frog   312 IEHADFAG-----VERLALVTGGEI----ASTFDHPE---------LVKLGTCKLIEEVMIGE-- 356

  Fly   354 VQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVA 418
                                 |:|....|...|...||.:.|.::..:.|.:...:|||..:...
Frog   357 ---------------------DKLIHFSGVAMGEACTIVLRGATQQILDEAERSLHDALCVLAQT 400

  Fly   419 ISD-GVVPGGGTAYLRCIPVLDELPPTDIMELQVGREIVKDALRLPCYTIARNAGVDPNEVLRRV 482
            :.| ..|.|||.:.:.....:.||......:..|..|....|||:....||.|||.|..:::.::
Frog   401 VKDTRTVYGGGCSEMLMAHAVTELAIRTPGKESVAMESFAKALRMLPTIIADNAGYDSADLVSQL 465

  Fly   483 ----LKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLATTEVLITKQPTKPKI 543
                .:|...||.|...|..|::...||.:..:|.:..:.||:..|.::...:.:|...|.| ::
Frog   466 RAAHSEGKSTYGLDMKNGTIGEMGELGITESFQVKRQVLLSASEAAEVILRVDNIIKAAPRK-RV 529

  Fly   544 P 544
            |
Frog   530 P 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	126/586 (22%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	123/576 (21%)
cct2	NP_001006757.1	TCP1_beta	11..527	CDD:239452	123/579 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910