DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and CCT1

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_524450.2	Gene:	CCT1 / 42649	FlyBaseID:	FBgn0003676	Length:	557	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	129/571 - (22%)
Similarity:	226/571 - (39%)	Gaps:	101/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AGVRTFANDIRFGAEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQ 75
            ||.|      :.||..|...:.....::|.|.::|||.|.:.::...:....:|.||.|:...::
  Fly    11 AGTR------QSGASVRTQNVMAALSISNIVKSSLGPVGLDKMLVDDIGDVTVTNDGATILRLLE 69

  Fly    76 LGNRRQDMGVQLLRQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGILEGSR 140
            :    :....::|.:.....:.:||||||:..|||..:......:::| |::...:..|.....:
  Fly    70 V----EHPAAKVLVELAQLQDEEVGDGTTSVVILAAELLKNADELVKQ-KIHPTSIISGYRIACK 129

  Fly   141 AVCDALGE-MSQSVDTIGQ--VEAVAKVALN----GDERLAELIGDIILELGDSGVILLKESHSP 198
            ..|..:.| ::..||.:|:  :..:||.:::    |.:  ||....::::...|..|......:.
  Fly   130 EACKYISEHLTAPVDELGRDSLINIAKTSMSSKIIGAD--AEFFSAMVVDAAQSVKITDPRGQAA 192

  Fly   199 FDEAKI----------QEGITIASGYYSPFFAKQSHTLELEN----CL---LLLTLAKI------ 240
            :....|          :|.:.|.....:...|.|....::.|    ||   |..|..|:
  Fly   193 YSIKAINVLKAHGKSARESVLIPGYALNCTIASQQMPKKIVNAKIACLDFSLQKTKMKMGVQVLI 257

  Fly   241 ---DQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPSFGDEQCE-- 300
               |::|.| .|.||...|||..:|:    |:.:..:||...:........|:|.:....:.:
  Fly   258 NDPDKLEAI-RARELDITKERINMIL----GTGVNVVLVSGGVDDLCMKYFVEAGAMAVRRVKKS 317

  Fly   301 EMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQVQCRIQDIRELI 365
            :::.||.|||      |:.:..|:..|..|..:|.:                     :.:..|:.
  Fly   318 DLKIIAKATG------AAFITSLTNMDGEESFDASM---------------------VGEAAEVA 355

  Fly   366 DEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAV-RVAISDGVVPGGGT 429
            .|...|.||..:|....|.   .|:|.:.|.::....|.:...:|||..| ||..|..||.|||.
  Fly   356 QERICDDELILIKGTKARA---AASIILRGPNDFYCDEMERSVHDALCVVKRVLESKKVVAGGGC 417

  Fly   430 AYLRCIPVLDELPPTDIMELQVG-REIVKDALRLPCYTIARNAGVDPNEVLRRVLKGSGNYGYDA 493
            ........|:....:.....|:. .|..|..|.:| .|::.||..|..::   |.|....:....
  Fly   418 VEAALSIYLENFATSLASREQLAIAEFAKSLLVIP-KTLSVNAAKDATDL---VAKLRSYHNSSQ 478

  Fly   494 AAGEFGDL------VVRGIVDPTK---VLQSAMTSAAGIASLLATTEVLIT 535
            ...|..||      ::.|:|...|   ||:.||:.   |.||...||..||
  Fly   479 TKPERSDLKWTGLDLIEGVVRDNKKAGVLEPAMSK---IKSLKFATEAAIT 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	127/569 (22%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	126/564 (22%)
CCT1	NP_524450.2	TCP1_alpha	12..538	CDD:239451	128/570 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740