Protein Alignment Hsp60D and fab1

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Alignment Length: 533
• Identity: 104/533 - (19%)
• Similarity: 172/533 - (32%)
• Gaps: 174/533 - (32%)

  Fly    67 GITVANNVQLGNRRQDMGVQLLRQATNNTNNKVGDGTTTATIL---ARGIACQGMHVLRQSKVNV 128
            |.:.::|....:......|:.|...|:..|    .|.|.:.:|   :..:|.:..:.||..| :.
  Fly   118 GTSTSSNTAAEDSETSDRVETLPLPTSEAN----QGRTVSNVLKHISNIVATKNNNDLRNYK-DT 177

  Fly   129 QLLREGILEGSRAVCDALGEMSQSVDTI------------------GQVEAVAKVALNGDERLAE 175
            :|.|..:.:.....|   .:.||...|.                  .||.....:..:||.::..
  Fly   178 ELQRFWMPDSKAKEC---YDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCN 239

  Fly   176 LIGDII-------------------------LELGDSGVILLKESHSPFDEAKIQEGITIASGYY 215
            ....|:                         ||:.|||..|.|  |.....|.:....::  ||.
  Fly   240 YCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAK--HPQMQRAPLPRKTSV--GYQ 300

  Fly   216 SPFFAK-----------QSHTLELENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGS 269
            ...|:.           :.:.|:..|.|:.|.    :::::.||               |:|.|.
  Fly   301 EERFSSHPTYTTLSIDDRKNILQQSNSLITLH----EEMQRDLP---------------AQNCGQ 346

  Fly   270 DLLKILVLNNLQ-GRVQVCAV----KAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLS----- 324
            .|::.|..||.. ..||..|:    .|..|.:....:.|.:.|.:..|.....||.:|.|
  Fly   347 RLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSP 411

  Fly   325 --------EEDLGEVMEAVVDAKE-----------------THLLQPINVNEEQVQCRIQDIREL 364
                    |....:.|:...:.||                 :.||.....:|||:..::.....|
  Fly   412 QFEANPHAEPQPPKSMDQSAEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNL 476

  Fly   365 IDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISDGVVPGG-- 427
                  |.|.|::   |..|....|..|           :.:..::.|..:|..::...||||
  Fly   477 ------DQEWDKV---LQMLCSTAANHF-----------KPEHCSNDLMDIRNYVNFKKVPGGRR 521

  Fly   428 -------GTAYLRCIPVLD---ELPPTDIMELQ------------VGREIV----KDALRLPCYT 466
                   |.|:.:.:...|   .:|...|:.||            |..|.|    |:.||..|
  Fly   522 KDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVC-- 584

  Fly   467 IARNAGVDPNEVL 479
             ||.....||.||
  Fly   585 -ARIMSFKPNVVL 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	104/533 (20%)
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	8/63 (13%)
		DEP	329..397	CDD:214489	18/86 (21%)
		Fab1_TCP	464..717	CDD:239450	36/156 (23%)
		PIPKc_PIKfyve	1479..1796	CDD:340437