DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60D and fab1

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	104/533 - (19%)
Similarity:	172/533 - (32%)	Gaps:	174/533 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GITVANNVQLGNRRQDMGVQLLRQATNNTNNKVGDGTTTATIL---ARGIACQGMHVLRQSKVNV 128
            |.:.::|....:......|:.|...|:..|    .|.|.:.:|   :..:|.:..:.||..| :.
  Fly   118 GTSTSSNTAAEDSETSDRVETLPLPTSEAN----QGRTVSNVLKHISNIVATKNNNDLRNYK-DT 177

  Fly   129 QLLREGILEGSRAVCDALGEMSQSVDTI------------------GQVEAVAKVALNGDERLAE 175
            :|.|..:.:.....|   .:.||...|.                  .||.....:..:||.::..
  Fly   178 ELQRFWMPDSKAKEC---YDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCN 239

  Fly   176 LIGDII-------------------------LELGDSGVILLKESHSPFDEAKIQEGITIASGYY 215
            ....|:                         ||:.|||..|.|  |.....|.:....::  ||.
  Fly   240 YCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAK--HPQMQRAPLPRKTSV--GYQ 300

  Fly   216 SPFFAK-----------QSHTLELENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGS 269
            ...|:.           :.:.|:..|.|:.|.    :::::.||               |:|.|.
  Fly   301 EERFSSHPTYTTLSIDDRKNILQQSNSLITLH----EEMQRDLP---------------AQNCGQ 346

  Fly   270 DLLKILVLNNLQ-GRVQVCAV----KAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLS----- 324
            .|::.|..||.. ..||..|:    .|..|.:....:.|.:.|.:..|.....||.:|.|
  Fly   347 RLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSP 411

  Fly   325 --------EEDLGEVMEAVVDAKE-----------------THLLQPINVNEEQVQCRIQDIREL 364
                    |....:.|:...:.||                 :.||.....:|||:..::.....|
  Fly   412 QFEANPHAEPQPPKSMDQSAEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNL 476

  Fly   365 IDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISDGVVPGG-- 427
                  |.|.|::   |..|....|..|           :.:..::.|..:|..::...||||
  Fly   477 ------DQEWDKV---LQMLCSTAANHF-----------KPEHCSNDLMDIRNYVNFKKVPGGRR 521

  Fly   428 -------GTAYLRCIPVLD---ELPPTDIMELQ------------VGREIV----KDALRLPCYT 466
                   |.|:.:.:...|   .:|...|:.||            |..|.|    |:.||..|
  Fly   522 KDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVC-- 584

  Fly   467 IARNAGVDPNEVL 479
             ||.....||.||
  Fly   585 -ARIMSFKPNVVL 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	104/533 (20%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	104/533 (20%)
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	8/63 (13%)
		DEP	329..397	CDD:214489	18/86 (21%)
		Fab1_TCP	464..717	CDD:239450	36/156 (23%)
		PIPKc	1413..1797	CDD:295374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453473
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930