DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and Cct6b

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	XP_017452911.1	Gene:	Cct6b / 363658	RGDID:	1359453	Length:	543	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	127/606 - (20%)
Similarity:	226/606 - (37%)	Gaps:	176/606 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GAE-ARCLLMQGVNV-----LANAVATTLGPKGRNVLIEQLLISP----RITKDGITVANNVQLG 77
            ||| .|......||:     |.:.:..:|||||    ..::|:|.    ::||||..:.:.:|:
  Rat    10 GAEVTRSQAALAVNICAARGLQDVLRPSLGPKG----ALKMLVSGAGDIKLTKDGNVLLHEMQI- 69

  Fly    78 NRRQDMGVQLLRQATNNTNNKVGDGTTTATILARGIACQ-------GMH---------------- 119
               |.....::.:.....::..|||||:..::...:..|       |:|
  Rat    70 ---QHPTASIIAKVAAAQDHITGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFDVAKTKAL 131

  Fly   120 -VLRQSKVNVQLLREGILEGSRA---------VCDALGEMSQSVDTIGQVEAVAKVALNGDERLA 174
             ||.:.||..::.||.:|:.:|.         :.|.|.|.     .:..|.|:.:..:..|..:.
  Rat   132 EVLDKIKVQKEMKREMLLDVARTSLRTKVHTELADILTEA-----VVDSVLAIRRPGIPIDLFMV 191

  Fly   175 ELI-----GDIILELGD-----------SGVILLKESHSPFDEAKIQ-------------EGITI 210
            |::     .:...:.||           .|::|...:..|..:.::|             |...:
  Rat   192 EIVEMRHKSETDTQAGDRTQGLALPRLVRGLVLDHGARHPRMKKQVQDAYILICNVSLEYEKTEV 256

  Fly   211 ASGYYSPFFAKQSHTLELENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGSD--LLK 273
            :||::.....::...::.|...:      .|:|::|:...:....:.....::....|.|  .|:
  Rat   257 SSGFFYKTVEEKEKLVKAERKFI------EDRVQKIIDLKQKVCAESNKGFVVINQKGIDPVSLE 315

  Fly   274 ILVLNNLQGRVQVCAVKAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGE---VMEAV 335
            :|..:|:     |...:|      :...:|.:..|.||..:   :||.|||||.||.   |.|..
  Rat   316 MLAKHNI-----VALRRA------KRRNLERLTLACGGLAV---NSLEDLSEECLGHAGLVFEYT 366

  Fly   336 VDAKETHLLQPINVNEEQVQCRIQDIRELIDEAFTDVE--LDRLKTRLGRLQGHLATIFVGGTSE 398
                                        |.:|.||.:|  ::.|.          .|:.|.|.::
  Rat   367 ----------------------------LGEEKFTFIEDCVNPLS----------VTLLVKGPNK 393

  Fly   399 LEVSERKDRFNDALHAVRVAISDG-VVPGGGTA----------YLRCIPVLDELPPTDIMELQVG 452
            ..:.:.||...|.|.||:.||.|| ||||.|..          |..|:.          ...::|
  Rat   394 HTLIQIKDALRDGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHCVQ----------GRARLG 448

  Fly   453 REIVKDALRLPCYTIARNAGVDPNEVLRRV----LKGSGNYGYDAAAGEFGDLVVRGIVDPTKVL 513
            .:...|||.:....:|:|:|.|..|.|.::    .:.....|.|...||.......||.|...|.
  Rat   449 IQAFADALLIIPKVLAQNSGYDLQETLIKIQTKHAESKELVGIDLNTGEPMVAAEAGIWDNYCVK 513

  Fly   514 QSAMTSAAGIA-SLLATTEVL 533
            :..:.|...|| ::|...|::
  Rat   514 KHILHSCTVIATNVLLVDEIM 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	127/606 (21%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	127/606 (21%)
Cct6b	XP_017452911.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900