DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and CCT5

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_523707.1	Gene:	CCT5 / 36308	FlyBaseID:	FBgn0010621	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	116/552 - (21%)
Similarity:	212/552 - (38%)	Gaps:	139/552 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GAEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP----RITKDGITVANNVQLGNRRQDM 83
            |.:|....:.....:|:.:.|:|||||    ::::::||    .:|.||.|:...:::.:....:
  Fly    31 GTDAIKTHIMAARQIASTLKTSLGPKG----LDKIMVSPDGDVTVTNDGATIMKLMEVDHEIAKL 91

  Fly    84 GVQLLRQATNNTNNKVGDGTTTATIL-------ARGIACQGMHVLRQSKVNVQLLREGILEGSRA 141
            .|||    :.:.::::|||||...:|       |.|:..:|:|.:|        :.:|....::.
  Fly    92 MVQL----SQSQDDEIGDGTTGVVVLAGALLEQAEGLIDRGIHPIR--------IADGFELAAQC 144

  Fly   142 VCDALGEMSQ---------------SVDTIGQVEAVAKVALNGDERLAELIGDIILELGD----- 186
            ....|..::|               ::.|:|     :|:......::||:..|.:|.:.|
  Fly   145 AIKQLDAIAQPFPVDPKNKEPLIQIAMTTLG-----SKIVNKCHRQMAEMAVDAVLNVADIEKKD 204

  Fly   187 ----------------------SGVILLKE-SHSPFDEAKIQEGITIASGYYSPFFAKQSHTLEL 228
                                  .|||:.|. |||...:......:.|.:..:.|...|..|.|::
  Fly   205 VNFELIKIETKVGGRMEDSMLVKGVIVDKTLSHSQMPKELRNVKLAILTCPFEPPKPKTKHKLDV 269

  Fly   229 ENCLLLLTLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPS 293
            .:......|.:.:| |:....::..:.....|.|....|..:...:|:...|..   |..|..|
  Fly   270 TSAEDYRALREYEQ-EKFTQMVKQVKDAGATLAICQWGFDDEANHLLLQQELPA---VRWVGGP- 329

  Fly   294 FGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGE---VMEAVVDAKETHLLQPINVNEEQVQ 355
                   |:|.||.||||.::   ....:|:.|.||.   |.|......:..:|    |.||
  Fly   330 -------EIELIAIATGGRIV---PRFEELTPEKLGVAGLVREMAFGTSKDKML----VIEE--- 377

  Fly   356 CRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAIS 420
            |:                           .....|||:.|.:.:.::|.|...:||:..||..:.
  Fly   378 CK---------------------------NSKAVTIFLRGGNAMIIAEAKRSIHDAICVVRSLVK 415

  Fly   421 DG-VVPGGGTAYLRC-IPVLDELPPTDIMELQVGR--EIVKDALRLPCYTIARNAGVDPNEVL-- 479
            |. :|.|||.|.:.| :.|..|......:|....|  .:..:::.|   .:|.|:|:.|.|.|
  Fly   416 DSRIVYGGGAAEISCSLAVAKEADQLSTLEQYAFRAFSVALESIPL---ALAENSGLHPIETLSE 477

  Fly   480 ---RRVLKGSGNYGYDAAAGEFGDLVVRGIVD 508
               |:|.:...:.|.|.......|:....:|:
  Fly   478 LKARQVAEKKSSLGVDCMLSGDSDMKSHNVVE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	116/552 (21%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	116/552 (21%)
CCT5	NP_523707.1	TCP1_epsilon	11..536	CDD:239455	116/552 (21%)
CCT5	NP_523707.1	Cpn60_TCP1	45..534	CDD:278544	114/538 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453424
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740