DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and Cct5

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001004078.1	Gene:	Cct5 / 294864	RGDID:	735161	Length:	541	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	119/554 - (21%)
Similarity:	219/554 - (39%)	Gaps:	143/554 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GAEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP----RITKDGITVANNVQLGNRRQDM 83
            |.||....:.....:||.:.|:|||.|    ::::::..    .:|.||.|:.:.:.:.::...:
  Rat    30 GLEALKSHIMAAKAVANTMRTSLGPNG----LDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKL 90

  Fly    84 GVQLLRQATNNTNNKVGDGTTTATIL-------ARGIACQGMHVLRQSKVNVQLLREGILEGSRA 141
            .|:|    :.:.::::|||||...:|       |..:..:|:|.:|        :.:|..:.:|.
  Rat    91 MVEL----SKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR--------IADGYEQAARI 143

  Fly   142 VCDALGEMSQSV---------------DTIGQVEAVAKVALNGDERLAELIGDIILELGD----- 186
            ....|.::|.:|               .|:|     :||..:...::||:..:.:|.:.|
  Rat   144 AIQHLDKISDNVLVDINNPEPLIQTAKTTLG-----SKVVNSCHRQMAEIAVNAVLTVADMERRD 203

  Fly   187 ----------------------SGVILLKE-SHSPFDEAKIQEGITIASGYYSPFFAKQSHTLEL 228
                                  .|||:.|: ||....:..:...|.|.:..:.|...|..|.|::
  Rat   204 VDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKEVLNAKIAILTCPFEPPKPKTKHKLDV 268

  Fly   229 ENCLLLLTLAKI--DQVEQILPALELARLKE--RPLLIIAKNFGSDLLKILVLNNLQGRVQVCAV 289
            .:......|.|.  ::.|::     :|::||  ..|.|....|..:...:|:.|.|..   |..|
  Rat   269 TSVEDYKALQKYEKEKFEEM-----IAQIKETGANLAICQWGFDDEANHLLLQNGLPA---VRWV 325

  Fly   290 KAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDL---GEVMEAVVDAKETHLLQPINVNE 351
            ..|        |:|.||.||||.::   ...::|:.|.|   |.|.|......:..:|    |.|
  Rat   326 GGP--------EIELIAIATGGRIV---PRFSELTSEKLGFAGVVREISFGTTKDKML----VIE 375

  Fly   352 EQVQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVR 416
               ||:                           .....|||:.|.:::.:.|.|...:|||..:|
  Rat   376 ---QCK---------------------------NSRAVTIFIRGGNKMIIEEAKRSLHDALCVIR 410

  Fly   417 VAISDG-VVPGGGTAYLRC-IPVLDELPPTDIMELQVGREIVKDALRLPCYTIARNAGVDPNEVL 479
            ..|.|. ||.|||.|.:.| :.|..|......:| |.......|||.:....::.|:|::|.:.:
  Rat   411 NLIRDNRVVYGGGAAEISCALAVSQEADKCPTLE-QYAMRAFADALEVIPMALSENSGMNPIQTM 474

  Fly   480 -----RRVLKGSGNYGYDAAAGEFGDLVVRGIVD 508
                 |:|.:.:...|.|.......|:..:.:::
  Rat   475 TEVRARQVKESNPALGIDCLHKGSNDMQYQHVIE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	119/554 (21%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	119/554 (21%)
Cct5	NP_001004078.1	TCP1_epsilon	10..535	CDD:239455	119/554 (21%)
Cct5	NP_001004078.1	Cpn60_TCP1	44..533	CDD:278544	116/540 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810