DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hsp60D and Cct4

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_877966.1	Gene:	Cct4 / 29374	RGDID:	727937	Length:	539	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	123/570 - (21%)
Similarity:	230/570 - (40%)	Gaps:	118/570 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGNRRQDMGVQLL 88
            |:.|...:.....:|:|:.|:|||||.:.:|:.......||.||.|:...:|:.:....|.|:|
  Rat    31 AQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVEL- 94

  Fly    89 RQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGILEGSRAVCDALGEMSQSV 153
               :...:.:.|||||:..|:| |........|.|..::..::.|...:......:.|.:||:.|
  Rat    95 ---SKAQDIEAGDGTTSVVIIA-GSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPV 155

  Fly   154 -----DTI---GQVEAVAKVALNGDERLAELIGDIILELGDSG---------VILLKESHSPFDE 201
                 :|:   ......:||.......|:.:..:.::::.|..         :.::|:.....|:
  Rat   156 QLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDD 220

  Fly   202 AKIQEGITIA-----SGYYSPFFAK--------QSHTLELENCLLLLTLAKIDQV--EQILPALE 251
            .::.||:.:.     ||......||        .:...:::|.:::...|::|:|  |:....|.
  Rat   221 CELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILN 285

  Fly   252 LARLKERP---LLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPSFGDEQCEEMEDIAFATG--- 310
            |.:..::.   :|:|.|:...|.|..|.|:.| .::::..||     |.:.|::|.|....|
  Rat   286 LVKQIKKTGCNVLLIQKSILRDALSDLALHFL-NKMKIMVVK-----DIEREDIEFICKTIGTKP 344

  Fly   311 -GHL---LEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQVQCRIQDIRELIDEAFTD 371
             .|:   ..|....|:|:||                    :::|..
  Rat   345 VAHIDQFTPDMLGSAELAEE--------------------VSLNGS------------------- 370

  Fly   372 VELDRLKTRLGRL--------QGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISD-GVVPGG 427
                      |:|        .|...||.|.|:::|.:.|.:...:|||..:|..:.. .::.||
  Rat   371 ----------GKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGG 425

  Fly   428 GTAYLRCIPVLDELPPT-DIMELQVGREIVKDALRLPCYTIARNAGVDP----NEVLRRVLKGSG 487
            |...:.....|.|...| ..||....|... ||:.:...|:|.|||::|    .|:..|..:|..
  Rat   426 GAPEIELALRLTEYSRTLSGMESYCVRAFA-DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEK 489

  Fly   488 NYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAA-GIASLLATTEVLITK 536
            ..|.:...|...:::...:|.|..|..||:|.|. .:.|:|...:|:.|:
  Rat   490 TTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	123/570 (22%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	122/568 (21%)
Cct4	NP_877966.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		TCP1_delta	25..538	CDD:239454	122/567 (22%)
		Cpn60_TCP1	44..539	CDD:278544	120/555 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810