Protein Alignment Hsp60D and CCT5

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_036205.1
• Gene: CCT5 / 22948
• HGNCID: 1618
• Length: 541
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 112/517 - (21%)
• Similarity: 206/517 - (39%)
• Gaps: 126/517 - (24%)

  Fly    23 GAEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP----RITKDGITVANNVQLGNRRQDM 83
            |.||....:.....:||.:.|:|||.|    ::::::..    .:|.||.|:.:.:.:.::...:
Human    30 GLEALKSHIMAAKAVANTMRTSLGPNG----LDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKL 90

  Fly    84 GVQLLRQATNNTNNKVGDGTTTATIL-------ARGIACQGMHVLRQSKVNVQLLREGILEGSRA 141
            .|:|    :.:.::::|||||...:|       |..:..:|:|.:|        :.:|..:.:|.
Human    91 MVEL----SKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIR--------IADGYEQAARV 143

  Fly   142 VCDALGEMSQSV-----DTIGQVEAV-----AKVALNGDERLAELIGDIILELGD---------- 186
            ..:.|.::|.||     ||...::..     :||..:...::||:..:.:|.:.|
Human   144 AIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFEL 208

  Fly   187 -----------------SGVILLKESHSPFDEAKIQEG-ITIASGYYSPFFAKQSHTLELENCLL 233
                             .|||:.|:...|....|:::. |.|.:..:.|...|..|.|::.:...
Human   209 IKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVED 273

  Fly   234 LLTLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPSFGDEQ 298
            ...|.|.:: |:....::..:.....|.|....|..:...:|:.|||..   |..|..|
Human   274 YKALQKYEK-EKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPA---VRWVGGP------ 328

  Fly   299 CEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQ------VQCR 357
              |:|.||.||||.::   ...::|:.|.||          ...|:|.|:....:      .||:
Human   329 --EIELIAIATGGRIV---PRFSELTAEKLG----------FAGLVQEISFGTTKDKMLVIEQCK 378

  Fly   358 IQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISDG 422
                                       .....|||:.|.:::.:.|.|...:|||..:|..|.|.
Human   379 ---------------------------NSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDN 416

  Fly   423 -VVPGGGTAYLRC-IPVLDELPPTDIMELQVGREIVKDALRLPCYTIARNAGVDPNEVLRRV 482
             ||.|||.|.:.| :.|..|......:| |.......|||.:....::.|:|::|.:.:..|
Human   417 RVVYGGGAAEISCALAVSQEADKCPTLE-QYAMRAFADALEVIPMALSENSGMNPIQTMTEV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	112/517 (22%)
CCT5	NP_036205.1	TCP1_epsilon	10..535	CDD:239455	112/517 (22%)