DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp60D and Cct2

DIOPT Version :9

Sequence 1:	NP_609656.1	Gene:	Hsp60D / 34763	FlyBaseID:	FBgn0032525	Length:	558	Species:	Drosophila melanogaster
Sequence 2:	NP_001345696.1	Gene:	Cct2 / 12461	MGIID:	107186	Length:	535	Species:	Mus musculus

Alignment Length:	591	Identity:	133/591 - (22%)
Similarity:	239/591 - (40%)	Gaps:	134/591 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NDIRFGAE------ARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP------RITKDGITV 70
            |..:.||:      ||.....|...:.:.|.:||||||    ::::|:|.      .:|.||.|:
Mouse    10 NIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKG----MDKILLSSGRDAALMVTNDGATI 70

  Fly    71 ANNVQLGNRRQDMGVQLLRQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGI 135
            ..|:.:.|....:.|.:.|.    .:::||||||:.|:||..:..:...::.: |::.|.:..|.
Mouse    71 LKNIGVDNPAAKVLVDMSRV----QDDEVGDGTTSVTVLAAELLREAESLIAK-KIHPQTIISGW 130

  Fly   136 LEGSRAVCDALGEMSQSVD-------------TIGQVEAVAKVALNGDERLAELIGDIILELGDS 187
            .|.::|..:||  :|.:||             .|......:|:..:..:...:|..:.:|.|..|
Mouse   131 REATKAAREAL--LSSAVDHGSDEARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGS 193

  Fly   188 G----VILLKESHSPFDEAKIQEGITIAS--GYYSPFFAKQSHTLELENCLLLL----------- 235
            |    :.::|:......::.:.||..:..  |...|        ..:||..:|:
Mouse   194 GNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQP--------KRIENAKILIANTGMDTDKIK 250

  Fly   236 ---------TLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLN---NLQGRVQVCA 288
                     :.||:.::|.    .|..::||:...|:.......:.:.|:.|   .|.|...|.|
Mouse   251 IFGSRVRVDSTAKVAEIEH----AEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMA 311

  Fly   289 VKAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQ 353
            ::...|..     :|.:|..|||.:    :|..|..|         :|......|::.:.:.|:
Mouse   312 IEHADFAG-----VERLALVTGGEI----ASTFDHPE---------LVKLGSCKLIEEVMIGED- 357

  Fly   354 VQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVA 418
                     :||.  |:.|.|           |...||.:.|.::..:.|.:...:|||..:...
Mouse   358 ---------KLIH--FSGVAL-----------GEACTIVLRGATQQILDEAERSLHDALCVLAQT 400

  Fly   419 ISD-GVVPGGGTAYLRCIPVLDELPPTDIMELQVGREIV-----KDALRLPCYTIARNAGVDPNE 477
            :.| ..|.|||     |..:|.....|.:.....|:|.|     ..|||:....||.|||.|..:
Mouse   401 VKDPRTVYGGG-----CSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIADNAGYDSAD 460

  Fly   478 VLRRV----LKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLATTEVLITKQP 538
            ::.::    .:|....|.|...|..||:.|.||.:..:|.:..:.|||..|.::...:.:|...|
Mouse   461 LVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAP 525

  Fly   539 TKPKIP 544
            .| ::|
Mouse   526 RK-RVP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	PTZ00114	13..546	CDD:185455	133/591 (23%)
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	130/581 (22%)
Cct2	NP_001345696.1	TCP1_beta	11..527	CDD:239452	130/584 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0459
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810