Protein Alignment Hsp60D and CCT6B

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_006575.2
• Gene: CCT6B / 10693
• HGNCID: 1621
• Length: 530
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 125/583 - (21%)
• Similarity: 226/583 - (38%)
• Gaps: 147/583 - (25%)

  Fly    24 AEARCLLMQGVNV-----LANAVATTLGPKGRNVLIEQLLISP----RITKDGITVANNVQLGNR 79
            |.||..|  .||:     |.:.:.|.|||||    ..::|:|.    ::||||..:.:.:|:
Human    14 ARARAAL--AVNICAARGLQDVLRTNLGPKG----TMKMLVSGAGDIKLTKDGNVLLDEMQI--- 69

  Fly    80 RQDMGVQLLRQATNNTNNKVGDGTTT---------------------ATILARGIAC---QGMHV 120
             |.....|:.:.....::..|||||:                     ..|:|.|...   :.:.|
Human    70 -QHPTASLIAKVATAQDDVTGDGTTSNVLIIGELLKQADLYISEGLHPRIIAEGFEAAKIKALEV 133

  Fly   121 LRQSKVNVQLLREGILEGSRAVCDALGEMSQSVDTIGQVEAVAKVALNGDERLAELIGDIILELG 185
            |.:.||..::.|:.:|:.:|              |..|.:..|::|    :.|.|::.|.:|.:.
Human   134 LEEVKVTKEMKRKILLDVAR--------------TSLQTKVHAELA----DVLTEVVVDSVLAVR 180

  Fly   186 DSG-------VILLKESHSPFDEAKIQEGITIASGYYSPFFAKQSHTLELENCLLLLTLAKID-Q 242
            ..|       |.:::..|....:.|:.:|:.:..|...|...|:     :|:..:|:....:: :
Human   181 RPGYPIDLFMVEIMEMKHKLGTDTKLIQGLVLDHGARHPDMKKR-----VEDAFILICNVSLEYE 240

  Fly   243 VEQILPALELARLKERPLLIIA-KNFGSD-LLKILVLNNLQGRVQVCAVKAPSF------GDE-- 297
            ..::.........:|:..|:.| :.|..| :.||:.|.:     :|||.....|      |.:
Human   241 KTEVNSGFFYKTAEEKEKLVKAERKFIEDRVQKIIDLKD-----KVCAQSNKGFVVINQKGIDPF 300

  Fly   298 ----------------QCEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQP 346
                            :...||.::.|.||..:   :|..||:.:.||          ...|:..
Human   301 SLDSLAKHGIVALRRAKRRNMERLSLACGGMAV---NSFEDLTVDCLG----------HAGLVYE 352

  Fly   347 INVNEEQVQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDA 411
            ..:.||:.        ..|:|......:               |:.|.|.::..:::.||...|.
Human   353 YTLGEEKF--------TFIEECVNPCSV---------------TLLVKGPNKHTLTQVKDAIRDG 394

  Fly   412 LHAVRVAISDG-VVPGGGTAYLRCIPVLDELPPTDIMELQVGREIVKDALRLPCYTIARNAGVDP 475
            |.|::.||.|| :|||.|...:.....|.....:.....::|.:...|||.:....:|:|||.||
Human   395 LRAIKNAIEDGCMVPGAGAIEVAMAEALVTYKNSIKGRARLGVQAFADALLIIPKVLAQNAGYDP 459

  Fly   476 NEVLRRV----LKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIA-SLLATTEVL 533
            .|.|.:|    ::.....|.|...||.......|:.|...|.:..:.|...|| ::|...|::
Human   460 QETLVKVQAEHVESKQLVGVDLNTGEPMVAADAGVWDNYCVKKQLLHSCTVIATNILLVDEIM 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	125/583 (21%)
CCT6B	NP_006575.2	chap_CCT_zeta	3..530	CDD:274088	125/583 (21%)