Protein Alignment Hsp60D and CCT2

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_006422.1
• Gene: CCT2 / 10576
• HGNCID: 1615
• Length: 535
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 132/591 - (22%)
• Similarity: 240/591 - (40%)
• Gaps: 134/591 - (22%)

  Fly    18 NDIRFGAE------ARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISP------RITKDGITV 70
            |..:.||:      ||.....|...:.:.|.:||||||    ::::|:|.      .:|.||.|:
Human    10 NIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKG----MDKILLSSGRDASLMVTNDGATI 70

  Fly    71 ANNVQLGNRRQDMGVQLLRQATNNTNNKVGDGTTTATILARGIACQGMHVLRQSKVNVQLLREGI 135
            ..|:.:.|....:.|.:.|.    .:::||||||:.|:||..:..:...::.: |::.|.:..|.
Human    71 LKNIGVDNPAAKVLVDMSRV----QDDEVGDGTTSVTVLAAELLREAESLIAK-KIHPQTIIAGW 130

  Fly   136 LEGSRAVCDALGEMSQSVD-------------TIGQVEAVAKVALNGDERLAELIGDIILELGDS 187
            .|.::|..:||  :|.:||             .|......:|:..:..:...:|..:.:|.|..|
Human   131 REATKAAREAL--LSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGS 193

  Fly   188 G----VILLKESHSPFDEAKIQEGITIAS--GYYSPFFAKQSHTLELENCLLLL----------- 235
            |    :.::|:......::.:.||..:..  |...|        ..:||..:|:
Human   194 GNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQP--------KRIENAKILIANTGMDTDKIK 250

  Fly   236 ---------TLAKIDQVEQILPALELARLKERPLLIIAKNFGSDLLKILVLN---NLQGRVQVCA 288
                     :.||:.::|.    .|..::||:...|:.......:.:.|:.|   .|.|...|.|
Human   251 IFGSRVRVDSTAKVAEIEH----AEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMA 311

  Fly   289 VKAPSFGDEQCEEMEDIAFATGGHLLEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQ 353
            ::...|..     :|.:|..|||.:    :|..|..|         :|......|::.:.:.|:
Human   312 IEHADFAG-----VERLALVTGGEI----ASTFDHPE---------LVKLGSCKLIEEVMIGED- 357

  Fly   354 VQCRIQDIRELIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVA 418
                     :||.  |:.|.|           |...||.:.|.::..:.|.:...:|||..:...
Human   358 ---------KLIH--FSGVAL-----------GEACTIVLRGATQQILDEAERSLHDALCVLAQT 400

  Fly   419 ISDG-VVPGGGTAYLRCIPVLDELPPTDIMELQVGREIV-----KDALRLPCYTIARNAGVDPNE 477
            :.|. .|.|||     |..:|.....|.:.....|:|.|     ..|||:....||.|||.|..:
Human   401 VKDSRTVYGGG-----CSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSAD 460

  Fly   478 VLRRV----LKGSGNYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAAGIASLLATTEVLITKQP 538
            ::.::    .:|:...|.|...|..||:.:.||.:..:|.:..:.|||..|.::...:.:|...|
Human   461 LVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAP 525

  Fly   539 TKPKIP 544
            .| ::|
Human   526 RK-RVP 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	129/581 (22%)
CCT2	NP_006422.1	TCP1_beta	11..527	CDD:239452	129/584 (22%)