Protein Alignment Hsp60D and CCT4

DIOPT Version :10

• Sequence 1: NP_609656.1
• Gene: Hsp60D / 34763
• FlyBaseID: FBgn0032525
• Length: 558
• Species: Drosophila melanogaster
• Sequence 2: NP_006421.2
• Gene: CCT4 / 10575
• HGNCID: 1617
• Length: 539
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 125/570 - (21%)
• Similarity: 235/570 - (41%)
• Gaps: 118/570 - (20%)

  Fly    24 AEARCLLMQGVNVLANAVATTLGPKGRNVLIEQLLISPRITKDGITVANNVQLGNRRQDMGVQLL 88
            |:.|...:.....:|:|:.|:|||||.:.:|:.......||.||.|:...:|:.:....|.|:|
Human    31 AQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVEL- 94

  Fly    89 RQATNNTNNKVGDGTTTATILARGI--AC-----QGMHVLRQSKVNVQLLREGILEGSRAVCDAL 146
               :...:.:.|||||:..|:|..:  :|     :|:|....|:...:.|.:||        :.|
Human    95 ---SKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGI--------EIL 148

  Fly   147 GEMSQSVDTIGQVEAV---------AKVALNGDERLAELIGDIILELGDSG---------VILLK 193
            .:||:.|: :...|.:         :||.......|:.:..:.::::.|..         :.::|
Human   149 TDMSRPVE-LSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVK 212

  Fly   194 ESHSPFDEAKIQEGITIA-----SGYYSPFFAK--------QSHTLELENCLLLLTLAKIDQV-- 243
            :.....|:.::.||:.:.     ||......||        .:...:::|.:::...|::|:|
Human   213 KLGGTIDDCELVEGLVLTQKVSNSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLR 277

  Fly   244 EQILPALELARLKERP---LLIIAKNFGSDLLKILVLNNLQGRVQVCAVKAPSFGDEQCEEMEDI 305
            |:....|.|.:..::.   :|:|.|:...|.|..|.|:.| .::::..:|     |.:.|::|.|
Human   278 EERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFL-NKMKIMVIK-----DIEREDIEFI 336

  Fly   306 AFATG----GHL---LEDASSLADLSEEDLGEVMEAVVDAKETHLLQPINVNEEQVQCRIQDIRE 363
            ....|    .|:   ..|....|:|:||                    :|:|......:|.....
Human   337 CKTIGTKPVAHIDQFTADMLGSAELAEE--------------------VNLNGSGKLLKITGCAS 381

  Fly   364 LIDEAFTDVELDRLKTRLGRLQGHLATIFVGGTSELEVSERKDRFNDALHAVRVAISD-GVVPGG 427
                                 .|...||.|.|:::|.:.|.:...:|||..:|..:.. .::.||
Human   382 ---------------------PGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGG 425

  Fly   428 GTAYLRCIPVLDELPPT-DIMELQVGREIVKDALRLPCYTIARNAGVDP----NEVLRRVLKGSG 487
            |...:.....|.|...| ..||....|... ||:.:...|:|.|||::|    .|:..|..:|..
Human   426 GAPEIELALRLTEYSRTLSGMESYCVRAFA-DAMEVIPSTLAENAGLNPISTVTELRNRHAQGEK 489

  Fly   488 NYGYDAAAGEFGDLVVRGIVDPTKVLQSAMTSAA-GIASLLATTEVLITK 536
            ..|.:...|...:::...:|.|..|..||:|.|. .:.|:|...:|:.|:
Human   490 TAGINVRKGGISNILEELVVQPLLVSVSALTLATETVRSILKIDDVVNTR 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp60D	NP_609656.1	GroEL	18..536	CDD:239460	124/568 (22%)
CCT4	NP_006421.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29
		TCP1_delta	25..538	CDD:239454	124/567 (22%)