DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacd2 and Hacd3

DIOPT Version :9

Sequence 1:	NP_609655.2	Gene:	Hacd2 / 34762	FlyBaseID:	FBgn0032524	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_067320.2	Gene:	Hacd3 / 57874	MGIID:	1889341	Length:	362	Species:	Mus musculus

Alignment Length:	369	Identity:	132/369 - (35%)
Similarity:	206/369 - (55%)	Gaps:	15/369 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSPFVYWSQTKQTLLLKVDLKDAKGAIADFSPVSVNFSANGHGARGVNAYKFELHFYALIDDENA 68
            |:|.|||:|..:.|.|:|:|.|.:......:...::|.|.||||:|.|.|:|.|.|..|:..|.|
Mouse     6 LTPHVYWAQRHRELYLRVELSDVQNPAISITDNVLHFKAQGHGAKGDNVYEFHLEFLDLVKPEPA 70

  Fly    69 TFVVSDNKIELQIRKLEPEWWPRLVATPQKPHWLKIDFDRWRTEDDVEVEEKPRDVRQDYEKEYA 133
             :.::..::.:.::|....||.||....::|.:|..|||||..|.|.|:|     :|...|:...
Mouse    71 -YRLTQRQVNITVQKKGSHWWERLTKQEKRPLFLAPDFDRWLDESDAEME-----LRAKEEERLN 129

  Fly   134 DLQKRELGYIKEKT--KKVYMIFYNLAMFVGYLYIMVVMGVLYYRDGVDSIGKTYANVGNAFKFI 196
            .|:....|..:..|  ||.|:..|||...:|:.:|.|.:.|.::..|.:|...|:.||.:...|.
Mouse   130 KLRLEREGSPETLTNLKKGYLFMYNLVQLLGFSWIFVNLTVRFFILGKESFYDTFHNVADMMYFC 194

  Fly   197 QLLQYLEVMHPMFGYTKGSPVVP-FFQVSGRNFILFLMIDMEPRMYAKPVVFYVFIIWSLVELVR 260
            |:|..:|.::...|.| .:||:| ..|..||||||||:......|..|.|||:||..||.:|:.|
Mouse   195 QMLALVETLNAAIGVT-STPVLPALIQFLGRNFILFLVFGTMEEMQNKAVVFFVFYSWSAIEIFR 258

  Fly   261 YPYYLAQLLGREVGLLTWLRYTIWIPLYPMGILCEGIIVLRNIPYIEETKRFTVEMPNPWNITFD 325
            ||:|:...:..:..:|||||||:||||||:|.|.|.:.|:::||...|:.||:..:|.|..:...
Mouse   259 YPFYMLSCIDMDWKVLTWLRYTMWIPLYPLGCLSEAVAVIQSIPVFNESGRFSFTLPYPVKMKVR 323

  Fly   326 MVLFLKIYLMLLIIPGSYLVMSHMAKLRSKKLGKGRAKRQQHLH 369
            ...||::||::|.: |.|:...|:.|.|.::.|:.:.|    ||
Mouse   324 FSFFLQVYLVMLFL-GLYINFRHLYKQRRRRYGQKKKK----LH 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacd2	NP_609655.2	p23_hB-ind1_like	6..114	CDD:107222	38/107 (36%)
Hacd2	NP_609655.2	PTPLA	197..357	CDD:282269	65/160 (41%)
Hacd3	NP_067320.2	p23_hB-ind1_like	8..115	CDD:107222	38/107 (36%)
Hacd3	NP_067320.2	PTPLA	195..352	CDD:282269	65/158 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841877
Domainoid	1	1.000	131	1.000	Domainoid score	I5140
eggNOG	1	0.900	-	-		E1_COG5198
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9494
Inparanoid	1	1.050	241	1.000	Inparanoid score	I3327
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47944
OrthoDB	1	1.010	-	-		D1458293at2759
OrthoFinder	1	1.000	-	-		FOG0008256
OrthoInspector	1	1.000	-	-		oto95192
orthoMCL	1	0.900	-	-		OOG6_108390
Panther	1	1.100	-	-	LDO	PTHR11035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1673
SonicParanoid	1	1.000	-	-		X7323
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800