DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hacd2 and HACD3

DIOPT Version :9

Sequence 1:	NP_609655.2	Gene:	Hacd2 / 34762	FlyBaseID:	FBgn0032524	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	NP_057479.2	Gene:	HACD3 / 51495	HGNCID:	24175	Length:	362	Species:	Homo sapiens

Alignment Length:	363	Identity:	129/363 - (35%)
Similarity:	204/363 - (56%)	Gaps:	11/363 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSPFVYWSQTKQTLLLKVDLKDAKGAIADFSPVSVNFSANGHGARGVNAYKFELHFYALIDDENA 68
            |:|.|||:|..:.|.|:|:|.|.:......:...::|.|.||||:|.|.|:|.|.|..|:..| .
Human     6 LTPHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLEFLDLVKPE-P 69

  Fly    69 TFVVSDNKIELQIRKLEPEWWPRLVATPQKPHWLKIDFDRWRTEDDVEVEEKPRDVRQDYEKEYA 133
            .:.::..::.:.::|...:||.||....::|.:|..|||||..|.|.|:|     :|...|:...
Human    70 VYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWLDESDAEME-----LRAKEEERLN 129

  Fly   134 DLQKRELGYIKEKT--KKVYMIFYNLAMFVGYLYIMVVMGVLYYRDGVDSIGKTYANVGNAFKFI 196
            .|:....|..:..|  :|.|:..|||..|:|:.:|.|.:.|.:...|.:|...|:..|.:...|.
Human   130 KLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFC 194

  Fly   197 QLLQYLEVMHPMFGYTKGSPVVP-FFQVSGRNFILFLMIDMEPRMYAKPVVFYVFIIWSLVELVR 260
            |:|..:|.::...|.|. |||:| ..|:.|||||||::......|..|.|||:||.:||.:|:.|
Human   195 QMLAVVETINAAIGVTT-SPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFR 258

  Fly   261 YPYYLAQLLGREVGLLTWLRYTIWIPLYPMGILCEGIIVLRNIPYIEETKRFTVEMPNPWNITFD 325
            |.:|:...:..:..:|||||||:||||||:|.|.|.:.|:::||...||.||:..:|.|..|...
Human   259 YSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVR 323

  Fly   326 MVLFLKIYLMLLIIPGSYLVMSHMAKLRSKKLGKGRAK 363
            ...||:|||:::.: |.|:...|:.|.|.::.|:.:.|
Human   324 FSFFLQIYLIMIFL-GLYINFRHLYKQRRRRYGQKKKK 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hacd2	NP_609655.2	p23_hB-ind1_like	6..114	CDD:107222	37/107 (35%)
Hacd2	NP_609655.2	PTPLA	197..357	CDD:282269	66/160 (41%)
HACD3	NP_057479.2	p23_hB-ind1_like	8..115	CDD:107222	37/107 (35%)
HACD3	NP_057479.2	PTPLA	195..355	CDD:309504	66/161 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151773
Domainoid	1	1.000	132	1.000	Domainoid score	I5119
eggNOG	1	0.900	-	-		E1_COG5198
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9494
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3360
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47944
OrthoDB	1	1.010	-	-		D1458293at2759
OrthoFinder	1	1.000	-	-		FOG0008256
OrthoInspector	1	1.000	-	-		oto91610
orthoMCL	1	0.900	-	-		OOG6_108390
Panther	1	1.100	-	-	LDO	PTHR11035
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1673
SonicParanoid	1	1.000	-	-		X7323
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.800