DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and TLR3

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_003256.1	Gene:	TLR3 / 7098	HGNCID:	11849	Length:	904	Species:	Homo sapiens

Alignment Length:	986	Identity:	198/986 - (20%)
Similarity:	339/986 - (34%)	Gaps:	292/986 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LPVVWLFFALLVLRSATGQIIPLPTFCLGLSPQCTCAAE----GNVVRFHCPDEYAMLLEVSE-- 63
            ||.::.:          |.::|....|...:.:||.:.|    .::.....||:....:.|..
Human     5 LPCIYFW----------GGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLT 59

  Fly    64 -------PGASLYMSYYASTEL---------------QWLPRFNISSLVKIEFDAYIFWPEKFLS 106
                   |.|: :..|...|.|               |.||...:.:|...|..........|.:
Human    60 HNQLRRLPAAN-FTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCT 123

  Fly   107 DL----LKTLGVQTVKTIIFRDRTLETVVTRDVLNSG---------------------NGYMETS 146
            :|    |.:..:|.:|...|..:  :.::|.|:.::|                     |..::..
Human   124 NLTELHLMSNSIQKIKNNPFVKQ--KNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQAL 186

  Fly   147 QPENITTWHFGSVPGLKKFKFFSH-VPELQESIFHGFDTLRDLHL-------------------- 190
            :.|.:..:...|   |||.:..|: :.|.....||....|..|.|
Human   187 KSEELDIFANSS---LKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANT 248

  Fly   191 SVNVTTLPGNMLSTVNGT---------LKTLTIESPGIVSFGNPLLRELQQL-------RNLSLA 239
            |:...:|..:.|||.:.|         |..|.:....:...||.....|.||       .|:...
Human   249 SIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHL 313

  Fly   240 LIHPFH----------ERDKQLQPHFFGSMTNLEEVRLA------------SATSSVNRSMFKGT 282
            ..|..|          :|....|.....|:..:::....            :....:..:||.|.
Human   314 FSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGL 378

  Fly   283 NKLQLIKM-NGNDDLMELPGEIFLDQVN--LKTLDLSCNAIVTLHEDVFKGLGNLTLLD------ 338
            ..|:.:.: |....|..|..|.|:...:  |..|:|:.|.|..:..|.|..||:|.:||
Human   379 INLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI 443

  Fly   339 -------------------LSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAM--SPSVFQDVVSL 382
                               ||.|:...|:...||.:.||..|.|.:.:|..:  |||.||.:.:|
Human   444 GQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNL 508

  Fly   383 NYIEMVNTQFYGATLLMNYEAVVCTNDEACQ----YKSAEWQCDPRCICWVQRSVGSLIVDCRGT 443
            ..:::.|..            :...||:..:    .:..:.|.:.....|...:.|..|...:|.
Human   509 TILDLSNNN------------IANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGL 561

  Fly   444 S-----------LEELP-DLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSL 496
            |           .:|:| ::.:......::.:|.|:|.:|| .|..:...::..|.|..|.:||:
Human   562 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLP-ASVFNNQVSLKSLNLQKNLITSV 625

  Fly   497 GSGDQLP--DNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFV--- 556
            ......|  .|||.||:|                           .||..|.|||::  :||
Human   626 EKKVFGPAFRNLTELDMR---------------------------FNPFDCTCESIA--WFVNWI 661

  Fly   557 ---RTN-------------------PQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVG 599
               .||                   |.|:.|      |...|.....|.|.:..:.:|||
Human   662 NETHTNIPELSSHYLCNTPPHYHGFPVRLFD------TSSCKDSAPFELFFMINTSILLI----- 715

  Fly   600 GLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVSE------EELDKDK---TYDAFISYSHKDE 655
              .|.|.||..|     :..:|..|      |.||.      :|:|:..   .|.|:|.:::||:
Human   716 --FIFIVLLIHF-----EGWRISFY------WNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDK 767

  Fly   656 ELISKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFI-DSVWARMEF 719
            :.:.:....:|......:.||.:||:..|....|.||.::..|:::|.|::.|.: |.:..|.:.
Human   768 DWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKV 832

  Fly   720 RIAYQATLQDKRKRIIIILYRELEHMNGIDSEL-------RAYLKLNTYLKWGDPLFWSKLYYAM 777
            ..|.|..::.....||::...|:.     |.:|       |...|.:..|.|  |:...:: .|.
Human   833 HHAVQQAIEQNLDSIILVFLEEIP-----DYKLNHALCLRRGMFKSHCILNW--PVQKERI-GAF 889

  Fly   778 PHNRRVLKGQK 788
            .|..:|..|.|
Human   890 RHKLQVALGSK 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/41 (20%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..261	CDD:275380	7/44 (16%)
		LRR_RI	<261..370	CDD:238064	32/148 (22%)
		leucine-rich repeat	262..284	CDD:275380	3/33 (9%)
		leucine-rich repeat	285..309	CDD:275380	6/24 (25%)
		LRR_8	309..368	CDD:290566	22/85 (26%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..357	CDD:275380	9/47 (19%)
		leucine-rich repeat	358..381	CDD:275380	9/24 (38%)
		leucine-rich repeat	445..482	CDD:275380	8/37 (22%)
		LRR_8	459..516	CDD:290566	18/58 (31%)
		leucine-rich repeat	483..505	CDD:275380	6/23 (26%)
		LRR_4	486..521	CDD:289563	12/36 (33%)
		TIR	643..779	CDD:214587	33/143 (23%)
TLR3	NP_003256.1	LRRNT	28..50	CDD:396168	5/21 (24%)
		leucine-rich repeat	33..52	CDD:275380	3/18 (17%)
		LRR 1	52..73		3/21 (14%)
		leucine-rich repeat	53..76	CDD:275380	4/23 (17%)
		PLN00113	72..>542	CDD:215061	91/486 (19%)
		LRR 2	76..97		2/20 (10%)
		leucine-rich repeat	77..100	CDD:275380	4/22 (18%)
		LRR 3	100..121		2/20 (10%)
		leucine-rich repeat	101..124	CDD:275380	3/22 (14%)
		LRR 4	124..145		5/20 (25%)
		leucine-rich repeat	125..148	CDD:275380	5/24 (21%)
		LRR 5	148..168		3/19 (16%)
		leucine-rich repeat	149..198	CDD:275380	5/48 (10%)
		LRR 6	172..193		2/20 (10%)
		LRR 7	198..219		7/23 (30%)
		leucine-rich repeat	199..249	CDD:275380	10/49 (20%)
		LRR 8	222..244		3/21 (14%)
		LRR 9	249..270		6/20 (30%)
		leucine-rich repeat	250..275	CDD:275380	5/24 (21%)
		LRR 10	275..296		4/20 (20%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		LRR 11	299..320		4/20 (20%)
		leucine-rich repeat	300..321	CDD:275380	4/20 (20%)
		LRR 12	323..344		3/20 (15%)
		LRR 13	356..377		2/20 (10%)
		leucine-rich repeat	357..380	CDD:275380	3/22 (14%)
		LRR 14	380..400		4/19 (21%)
		leucine-rich repeat	381..406	CDD:275380	6/24 (25%)
		LRR 15	408..429		7/20 (35%)
		leucine-rich repeat	409..432	CDD:275380	8/22 (36%)
		LRR 16	432..454		3/21 (14%)
		leucine-rich repeat	433..457	CDD:275380	3/23 (13%)
		leucine-rich repeat	458..481	CDD:275380	6/22 (27%)
		LRR 17	465..486		6/20 (30%)
		leucine-rich repeat	482..507	CDD:275380	9/24 (38%)
		LRR 18	507..528		4/32 (13%)
		leucine-rich repeat	508..531	CDD:275380	4/34 (12%)
		LRR 19	531..552		2/20 (10%)
		leucine-rich repeat	532..563	CDD:275380	5/30 (17%)
		LRR_8	562..622	CDD:404697	12/60 (20%)
		LRR 20	563..584		2/20 (10%)
		leucine-rich repeat	564..585	CDD:275380	2/20 (10%)
		LRR 21	587..608		6/21 (29%)
		leucine-rich repeat	588..611	CDD:275380	6/23 (26%)
		LRR 22	611..632		5/20 (25%)
		leucine-rich repeat	612..630	CDD:275380	5/17 (29%)
		leucine-rich repeat	637..659	CDD:275380	12/50 (24%)
		LRRCT	645..697	CDD:214507	14/59 (24%)
		Tlr3_TMD	698..730	CDD:407816	10/43 (23%)
		TIR	755..900	CDD:214587	36/152 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820