DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tehao and TLR2

DIOPT Version :9

Sequence 1:NP_001285901.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_001305716.1 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens


Alignment Length:800 Identity:185/800 - (23%)
Similarity:292/800 - (36%) Gaps:264/800 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 TELQWLPRFNISSLVKI---EFDAYIFWPEKFL--SDLL----KTL-GVQTVKTI---------- 120
            |:||.|...|:.:..||   :|....|..|..:  |||.    |:| .:|.|..:          
Human   149 TKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILL 213

  Fly   121 --IFRDRT--LETVVTRDVLNSGNGYMETSQPENITTWHFGSVPG------LKKFKFFSHVPELQ 175
              ||.|.|  :|.:..||.              ::.|:||..:..      :|||. |.:|....
Human   214 LEIFVDVTSSVECLELRDT--------------DLDTFHFSELSTGETNSLIKKFT-FRNVKITD 263

  Fly   176 ESIFHGFDTLRD----LHLSVNVTTL--PGNMLSTVN------GTLKTLTIESPGIVSFGNPLLR 228
            ||:|.....|..    |.|..:..||  .||..::.|      |.::||||              
Human   264 ESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTI-------------- 314

  Fly   229 ELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLEEVRLASATSSVNRSMFKGTNKLQLIKMNGN 293
                 |.|.:...:.|::..                 .|.|.|..|.|...:            |
Human   315 -----RRLHIPRFYLFYDLS-----------------TLYSLTERVKRITVE------------N 345

  Fly   294 DDLMELPGEIFLDQVNLKTLDLSCNAIVTLH------EDVFKGLGNLTLLDLSKNRLTNLSST-- 350
            ..:..:|..:.....:|:.||||.|.:|..:      ||.:..|..|.   |.:|.|.:|..|  
Human   346 SKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLI---LRQNHLASLEKTGE 407

  Fly   351 IFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYK 415
            ....|.:|..:.::|||..:| |...|....:.|:.:.:|:.:..|              .|   
Human   408 TLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRIHSVT--------------GC--- 454

  Fly   416 SAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLT----SLPTVSE 476
                                               :|:|.   .:|.|.||:|.    :||.:.|
Human   455 -----------------------------------IPKTL---EILDVSNNNLNLFSLNLPQLKE 481

  Fly   477 HSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTM-TLSLSG 540
                     |::|.|.|.:|.....|| .|..|.:..|.|.:.|.|.|    :..:|: ||...|
Human   482 ---------LYISRNKLMTLPDASLLP-MLLVLKISRNAITTFSKEQL----DSFHTLKTLEAGG 532

  Fly   541 NPITCGCESLSL---------------LFFVRTNPQRVRDIADIVCTKQKKSFQQMEAFELCPS- 589
            |...|.||.||.               ..::..:|..||.             ||::...|..| 
Human   533 NNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRG-------------QQVQDVRLSVSE 584

  Fly   590 --YVLLISCVVGGLVIVICLLTV----FY-LMFQQELKIWLY---------NNNLCLWWVSEEEL 638
              ...|:|.:...|.::|.|..|    |: |.:.:.:..||.         :.|:|         
Human   585 CHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNIC--------- 640

  Fly   639 DKDKTYDAFISYSHKDEELISKLL-PKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVI 702
                 ||||:|||.:|...:..|: .:||:...||:||||.||::.|..|.:.|:.:::.|.:.:
Human   641 -----YDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTV 700

  Fly   703 IVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS---ELRAYLKLNTYLKW 764
            .|||::|:.|.|.:.|...::.....:.....|:||...:| ...|..   :||..:...|||:|
Human   701 FVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIE-KKAIPQRFCKLRKIMNTKTYLEW 764

  Fly   765 GDPL-------FWSKLYYAM 777
              |:       ||..|..|:
Human   765 --PMDEAQREGFWVNLRAAI 782

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
TehaoNP_001285901.1 leucine-rich repeat 185..207 CDD:275380 8/33 (24%)
leucine-rich repeat 209..232 CDD:275380 4/22 (18%)
leucine-rich repeat 233..261 CDD:275380 3/27 (11%)
LRR_RI <261..370 CDD:238064 28/116 (24%)
leucine-rich repeat 262..284 CDD:275380 5/21 (24%)
leucine-rich repeat 285..309 CDD:275380 2/23 (9%)
LRR_8 309..368 CDD:290566 20/66 (30%)
leucine-rich repeat 310..333 CDD:275380 10/28 (36%)
leucine-rich repeat 334..357 CDD:275380 7/24 (29%)
leucine-rich repeat 358..381 CDD:275380 7/22 (32%)
leucine-rich repeat 445..482 CDD:275380 10/40 (25%)
LRR_8 459..516 CDD:290566 18/60 (30%)
leucine-rich repeat 483..505 CDD:275380 7/21 (33%)
LRR_4 486..521 CDD:289563 11/34 (32%)
TIR 643..779 CDD:214587 46/145 (32%)
TLR2NP_001305716.1 PLN00113 <40..>206 CDD:331614 17/56 (30%)
leucine-rich repeat 54..77 CDD:275380
LRR 1 54..77
LRR_8 77..135 CDD:316378
leucine-rich repeat 78..101 CDD:275380
LRR 2 78..101
leucine-rich repeat 102..125 CDD:275380
LRR 3 102..125