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Protein Alignment Tehao and TLR2

DIOPT Version :10

Sequence 1:	NP_477438.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_003255.2	Gene:	TLR2 / 7097	HGNCID:	11848	Length:	784	Species:	Homo sapiens

Alignment Length:	800	Identity:	185/800 - (23%)
Similarity:	292/800 - (36%)	Gaps:	264/800 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TELQWLPRFNISSLVKI---EFDAYIFWPEKFL--SDLL----KTL-GVQTVKTI---------- 120
            |:||.|...|:.:..||   :|....|..|..:  |||.    |:| .:|.|..:
Human   149 TKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILL 213

  Fly   121 --IFRDRT--LETVVTRDVLNSGNGYMETSQPENITTWHFGSVPG------LKKFKFFSHVPELQ 175
              ||.|.|  :|.:..||.              ::.|:||..:..      :|||. |.:|....
Human   214 LEIFVDVTSSVECLELRDT--------------DLDTFHFSELSTGETNSLIKKFT-FRNVKITD 263

  Fly   176 ESIFHGFDTLRD----LHLSVNVTTL--PGNMLSTVN------GTLKTLTIESPGIVSFGNPLLR 228
            ||:|.....|..    |.|..:..||  .||..::.|      |.::||||
Human   264 ESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTI-------------- 314

  Fly   229 ELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLEEVRLASATSSVNRSMFKGTNKLQLIKMNGN 293
                 |.|.:...:.|::..                 .|.|.|..|.|...:            |
Human   315 -----RRLHIPRFYLFYDLS-----------------TLYSLTERVKRITVE------------N 345

  Fly   294 DDLMELPGEIFLDQVNLKTLDLSCNAIVTLH------EDVFKGLGNLTLLDLSKNRLTNLSST-- 350
            ..:..:|..:.....:|:.||||.|.:|..:      ||.:..|..|.   |.:|.|.:|..|
Human   346 SKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLI---LRQNHLASLEKTGE 407

  Fly   351 IFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYK 415
            ....|.:|..:.::|||..:| |...|....:.|:.:.:|:.:..|              .|
Human   408 TLLTLKNLTNIDISKNSFHSM-PETCQWPEKMKYLNLSSTRIHSVT--------------GC--- 454

  Fly   416 SAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLT----SLPTVSE 476
                                               :|:|.   .:|.|.||:|.    :||.:.|
Human   455 -----------------------------------IPKTL---EILDVSNNNLNLFSLNLPQLKE 481

  Fly   477 HSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTM-TLSLSG 540
                     |::|.|.|.:|.....|| .|..|.:..|.|.:.|.|.|    :..:|: ||...|
Human   482 ---------LYISRNKLMTLPDASLLP-MLLVLKISRNAITTFSKEQL----DSFHTLKTLEAGG 532

  Fly   541 NPITCGCESLSL---------------LFFVRTNPQRVRDIADIVCTKQKKSFQQMEAFELCPS- 589
            |...|.||.||.               ..::..:|..||.             ||::...|..|
Human   533 NNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRG-------------QQVQDVRLSVSE 584

  Fly   590 --YVLLISCVVGGLVIVICLLTV----FY-LMFQQELKIWLY---------NNNLCLWWVSEEEL 638
              ...|:|.:...|.::|.|..|    |: |.:.:.:..||.         :.|:|
Human   585 CHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNIC--------- 640

  Fly   639 DKDKTYDAFISYSHKDEELISKLL-PKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVI 702
                 ||||:|||.:|...:..|: .:||:...||:||||.||::.|..|.:.|:.:::.|.:.:
Human   641 -----YDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTV 700

  Fly   703 IVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS---ELRAYLKLNTYLKW 764
            .|||::|:.|.|.:.|...::.....:.....|:||...:| ...|..   :||..:...|||:|
Human   701 FVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIE-KKAIPQRFCKLRKIMNTKTYLEW 764

  Fly   765 GDPL-------FWSKLYYAM 777
              |:       ||..|..|:
Human   765 --PMDEAQREGFWVNLRAAI 782

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.