DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr8

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001094479.1	Gene:	Tlr8 / 684440	RGDID:	1590327	Length:	1029	Species:	Rattus norvegicus

Alignment Length:	886	Identity:	190/886 - (21%)
Similarity:	327/886 - (36%)	Gaps:	239/886 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LQWLPRFNISSLVKIE----------------FDAYIFWPEKFLSDLLKT-LGVQTVKTIIFRD- 124
            |.|...|..:.:.|:|                |:.....|.|..|.|.|. |....:.||...|
  Rat   170 LGWNCYFKCNQIFKVEDGAFNNLINLKLLSLSFNNLFSVPPKLPSSLSKLFLSNAKISTITQEDF 234

  Fly   125 RTLETVVTRDVLNSGNGYMETSQP-------------------ENITTWHFGSVPGLKKFKFFSH 170
            :.||.::..|:  |||.....:.|                   :|:|...|.::..       :.
  Rat   235 KGLEHLILLDL--SGNCPRCFNAPFPCESCNLSASIRIHPLAFQNLTQLRFLNLSS-------TS 290

  Fly   171 VPELQESIFHGFDTLRDLHLSVN--VTTLPGNMLSTVNGTLKTLTIESPGIVSFG---------- 223
            :..:..:.|.....|::|||..|  |..:......|...:|:||.:      ||.
  Rat   291 LRTIPSTWFDNLTNLKELHLEFNYLVQEIASGAFLTKLPSLQTLDL------SFNFIHKEYLQYI 349

  Fly   224 --NPLLRELQQLRNLSLALIHPFHERDKQLQPHF--FGSMTNLEEVRLA-SATSSVNRSMFKGTN 283
              :|....|:.||.|.|. .:.|.|..|:   ||  ..::.||..:.|. :....::...|:...
  Rat   350 TISPNFSMLRSLRKLHLK-GYVFRELKKE---HFKPLQNLPNLTTINLGINFIEKIDFKAFQDFP 410

  Fly   284 KLQLIKMNGNDDLMELPG------------------EIFLDQVNL----------------KTLD 314
            .|::|.::||.....:.|                  :.|...:|.                |.||
  Rat   411 NLKVIYLSGNRIASVIDGTDHSSWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALD 475

  Fly   315 LSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTN---LSSTIFAPLTSLNVLRLNKNSLTAMSPSVF 376
            ||.|.|..:.:..|:|..::..|:||.|  .|   |:.|.|:.:..:..|.|..|.|.......|
  Rat   476 LSLNNIFVIGKSQFEGFQDIACLNLSFN--ANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTF 538

  Fly   377 QDVVSLNYIEMVNTQFY----GAT--------------LLMNYEAVVCTNDE-ACQYKSAE---- 418
            .|:..|..:::.:...|    |.|              |.:::..:....|| ..|.||.:
  Rat   539 SDLHDLEVLDLSHNAHYFSIAGVTHRLGFIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVF 603

  Fly   419 --------WQCDPRCICWVQRSVGSLI-VDCRGTSLEELP-----DLPRT--------------- 454
                    |..:......:..|:.:|. :|....:|:::|     :||::
  Rat   604 SGNRLDRLWNANDGKYWSIFTSLETLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDNRLRFFN 668

  Fly   455 -TLLS-----TVLKVGNNS---LTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPD--NLTH 508
             |||.     .||.:|.|.   ||:..:...||    :..|.|:.|:.:.|.:| .|.:  ||.:
  Rat   669 WTLLQYFPHLHVLDLGRNELYFLTNCLSKFTHS----LKTLLLNHNHFSHLPAG-FLSEARNLVY 728

  Fly   509 LDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQ-RVRDIADIVCT 572
            ||:..|.|:.::...|. .:...|...|.|.||...|.|:......::..||. |:..:.|::|:
  Rat   729 LDLSFNTIKMINKSSLQ-TETKTNLSVLDLQGNHFDCTCDISDFRSWLEENPHVRIPRLVDVICS 792

  Fly   573 ----KQKKSFQQMEAFELCPSYVLLISCVVGGLVIVICLL------TVFYLMFQQELKIWLYNNN 627
                ::.||...::          |.:||......::...      ||........|..|
  Rat   793 NPGDQRWKSVMSLD----------LTTCVSDTTAAILFFFTFLTTSTVLLAALVHHLFYW----- 842

  Fly   628 LCLWWV----------SEEELDKDKTYDAFISYSHKDEELISKLLPKL-----ESGPHPFRLCLH 677
             .:|::          ..........|||:|||..||..:...::.:|     ||......|||.
  Rat   843 -DVWFIYHMCSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLE 906

  Fly   678 DRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQ---DKRKRIIIILY 739
            :|||..|..|.:.::::::.||:.|.||::.:..| |   .|:.|:...||   |:...:||.:.
  Rat   907 ERDWDPGLPIIDNLMQSINQSKKTIFVLTKKYAKS-W---NFKTAFYLALQRLMDENMDVIIFIL 967

  Fly   740 RE--LEHMNGIDSELRAYLKLNTYLKW-----GDPLFWSKL 773
            .|  |::...:  .||..:..::.|:|     .:.|||..|
  Rat   968 LEPVLQYSQYL--RLRQRICKSSILQWPNNPKAENLFWQSL 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	7/23 (30%)
		leucine-rich repeat	209..232	CDD:275380	7/34 (21%)
		leucine-rich repeat	233..261	CDD:275380	9/29 (31%)
		LRR_RI	<261..370	CDD:238064	32/146 (22%)
		leucine-rich repeat	262..284	CDD:275380	3/22 (14%)
		leucine-rich repeat	285..309	CDD:275380	6/41 (15%)
		LRR_8	309..368	CDD:290566	21/77 (27%)
		leucine-rich repeat	310..333	CDD:275380	9/38 (24%)
		leucine-rich repeat	334..357	CDD:275380	8/25 (32%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	445..482	CDD:275380	15/65 (23%)
		LRR_8	459..516	CDD:290566	19/61 (31%)
		leucine-rich repeat	483..505	CDD:275380	6/23 (26%)
		LRR_4	486..521	CDD:289563	12/36 (33%)
		TIR	643..779	CDD:214587	43/146 (29%)
Tlr8	NP_001094479.1	PRK15370	<21..>218	CDD:185268	10/47 (21%)
		leucine-rich repeat	62..85	CDD:275380
		leucine-rich repeat	86..119	CDD:275380
		leucine-rich repeat	120..140	CDD:275380
		PLN00113	141..>664	CDD:215061	101/514 (20%)
		leucine-rich repeat	141..164	CDD:275380
		leucine-rich repeat	165..194	CDD:275380	5/23 (22%)
		leucine-rich repeat	195..215	CDD:275380	3/19 (16%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..280	CDD:275380	6/41 (15%)
		leucine-rich repeat	281..304	CDD:275380	2/29 (7%)
		leucine-rich repeat	305..324	CDD:275380	6/18 (33%)
		leucine-rich repeat	331..387	CDD:275380	16/65 (25%)
		leucine-rich repeat	388..411	CDD:275380	3/22 (14%)
		leucine-rich repeat	467..494	CDD:275380	9/26 (35%)
		leucine-rich repeat	495..510	CDD:275380	5/16 (31%)
		leucine-rich repeat	520..543	CDD:275380	6/22 (27%)
		leucine-rich repeat	544..573	CDD:275380	4/28 (14%)
		leucine-rich repeat	574..597	CDD:275380	4/22 (18%)
		leucine-rich repeat	598..628	CDD:275380	2/29 (7%)
		PRK15370	<629..>739	CDD:185268	29/114 (25%)
		leucine-rich repeat	629..653	CDD:275380	6/23 (26%)
		leucine-rich repeat	654..677	CDD:275380	3/22 (14%)
		leucine-rich repeat	678..701	CDD:275380	6/22 (27%)
		leucine-rich repeat	702..725	CDD:275380	6/23 (26%)
		leucine-rich repeat	726..745	CDD:275380	5/18 (28%)
		PCC	730..>813	CDD:188093	21/93 (23%)
		TIR	868..1004	CDD:214587	41/141 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820