DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and TLR8

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_057694.2	Gene:	TLR8 / 51311	HGNCID:	15632	Length:	1059	Species:	Homo sapiens

Alignment Length:	878	Identity:	197/878 - (22%)
Similarity:	323/878 - (36%)	Gaps:	301/878 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GASLYMSYYASTELQWLPRFNIS--SLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTL 127
            |||:.:..:|...|..|...|:|  ||.||....:...|...:.||.....|..:.:..|.
Human   291 GASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFL---- 351

  Fly   128 ETVVTR-DVLNSGNGYMETSQPENIT-TWHFGSVPGLKKFKFFSHV-PELQESIFHGFDTLRDLH 189
             |::.| ::|:....|::.|.|::|. :.:|..:..|:......:| .||:|..|.
Human   352 -TMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQ--------- 406

  Fly   190 LSVNVTTLPGNMLSTVN-GTLKTLTIESPGIVSFGN------------PLLRELQQLRNLSLALI 241
               .:..||.  |||:| |......|:.....:|.|            ||:::.:|....|.:..
Human   407 ---PLMQLPN--LSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 466

  Fly   242 HPFHER---DKQLQPH-----------------------------FF---GSMTNLEEVRLASAT 271
            ....:|   |.:..||                             ||   ....||.::...:.:
Human   467 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLS 531

  Fly   272 SSVNRSMFKGT-----------------------------NKLQLIKMNGNDDLMELPG-----E 302
            ::.|..:..||                             :.|:::.::.|.....:.|     |
Human   532 ANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLE 596

  Fly   303 IFLDQVNLKTLDLSCNAIVTLHE-------------------------------DVFKGLGNLTL 336
            ...:..|||.|:||.|.|.||.:                               .:||||.|||.
Human   597 FIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTR 661

  Fly   337 LDLSKNRLTNLSSTIFAPL-TSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMN 400
            ||||.|||.::.:..|..| .||..|.:|.|.|                      :|:..|||..
Human   662 LDLSLNRLKHIPNEAFLNLPASLTELHINDNML----------------------KFFNWTLLQQ 704

  Fly   401 YEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSL----EELPDLPRTTLLSTVL 461
            :                     ||.          .::|.||..|    :.|.|.  |:.|.|:|
Human   705 F---------------------PRL----------ELLDLRGNKLLFLTDSLSDF--TSSLRTLL 736

  Fly   462 KVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLF 526
             :.:|.::.||           || |||:            ..:|.|||:..|.:::::...|
Human   737 -LSHNRISHLP-----------SG-FLSE------------VSSLKHLDLSSNLLKTINKSAL-- 774

  Fly   527 LQEPNNTMTLS---LSGNPITCGC----------ESLSLLFFVRTNPQRVRDIADIVCT----KQ 574
              |...|..||   |.|||..|.|          |.|::         ::..:.|::|.    ::
Human   775 --ETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNV---------KIPRLVDVICASPGDQR 828

  Fly   575 KKSFQQMEAFELCPSYVLLISCVVGGLVIVICLLTVF-----------YLMFQQELKIW-LYNNN 627
            .||...:|          |.:||.....:::...|.|           :.:|..:  :| :|  |
Human   829 GKSIVSLE----------LTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWD--VWFIY--N 879

  Fly   628 LCLWWV-SEEELDKDKT-YDAFISYSHKDEELISKLLPKL-----ESGPHPFRLCLHDRDWLVGD 685
            :||..| ....|...:| |||:|||..||..:...::.:|     ||......|||.:|||..|.
Human   880 VCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGL 944

  Fly   686 CIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQ---DKRKRIIIILYRE--LEHM 745
            .|.:.::::::.||:.:.||::.:..| |   .|:.|:...||   |:...:||.:..|  |:|.
Human   945 AIIDNLMQSINQSKKTVFVLTKKYAKS-W---NFKTAFYLALQRLMDENMDVIIFILLEPVLQHS 1005

  Fly   746 NGIDSELRAYLKLNTYLKWGD-----PLFWSKL 773
            ..:  .||..:..::.|:|.|     .|||..|
Human  1006 QYL--RLRQRICKSSILQWPDNPKAEGLFWQTL 1036

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..232	CDD:275380	5/34 (15%)
		leucine-rich repeat	233..261	CDD:275380	7/62 (11%)
		LRR_RI	<261..370	CDD:238064	41/174 (24%)
		leucine-rich repeat	262..284	CDD:275380	4/50 (8%)
		leucine-rich repeat	285..309	CDD:275380	4/28 (14%)
		LRR_8	309..368	CDD:290566	31/90 (34%)
		leucine-rich repeat	310..333	CDD:275380	13/53 (25%)
		leucine-rich repeat	334..357	CDD:275380	11/23 (48%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	445..482	CDD:275380	10/40 (25%)
		LRR_8	459..516	CDD:290566	15/56 (27%)
		leucine-rich repeat	483..505	CDD:275380	5/21 (24%)
		LRR_4	486..521	CDD:289563	8/34 (24%)
		TIR	643..779	CDD:214587	45/147 (31%)
TLR8	NP_057694.2	LRR_8	83..155	CDD:290566
		leucine-rich repeat	83..106	CDD:275380
		leucine-rich repeat	107..144	CDD:275380
		leucine-rich repeat	145..165	CDD:275380
		leucine-rich repeat	166..189	CDD:275380
		leucine-rich repeat	190..220	CDD:275380
		leucine-rich repeat	221..241	CDD:275380
		LRR_8	240..317	CDD:290566	8/25 (32%)
		leucine-rich repeat	242..265	CDD:275380
		leucine-rich repeat	266..306	CDD:275380	5/14 (36%)
		LRR_8	305..367	CDD:290566	15/66 (23%)
		leucine-rich repeat	307..330	CDD:275380	7/22 (32%)
		leucine-rich repeat	331..356	CDD:275380	5/29 (17%)
		leucine-rich repeat	387..413	CDD:275380	7/37 (19%)
		LRR_8	412..>449	CDD:290566	9/38 (24%)
		leucine-rich repeat	414..437	CDD:275380	7/22 (32%)
		LRR_8	502..560	CDD:290566	7/57 (12%)
		LRR_RI	<504..719	CDD:238064	52/267 (19%)
		leucine-rich repeat	504..524	CDD:275380	4/19 (21%)
		leucine-rich repeat	525..549	CDD:275380	3/23 (13%)
		LRR_8	548..614	CDD:290566	11/65 (17%)
		leucine-rich repeat	550..573	CDD:275380	0/22 (0%)
		leucine-rich repeat	574..603	CDD:275380	4/28 (14%)
		leucine-rich repeat	604..658	CDD:275380	13/53 (25%)
		LRR_8	657..718	CDD:290566	27/113 (24%)
		leucine-rich repeat	659..683	CDD:275380	11/23 (48%)
		leucine-rich repeat	684..707	CDD:275380	9/65 (14%)
		LRR_8	706..766	CDD:290566	25/96 (26%)
		leucine-rich repeat	708..730	CDD:275380	6/33 (18%)
		leucine-rich repeat	732..755	CDD:275380	11/47 (23%)
		leucine-rich repeat	756..775	CDD:275380	6/22 (27%)
		LRRCT	790..835	CDD:214507	10/53 (19%)
		TIR	898..1040	CDD:214587	44/145 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820