DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tehao and TLR7

DIOPT Version :9

Sequence 1:NP_001285901.1 Gene:Tehao / 34761 FlyBaseID:FBgn0026760 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:993 Identity:219/993 - (22%)
Similarity:381/993 - (38%) Gaps:282/993 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 LTYLPVVWLFFALLVLRSATGQIIPLPTFCLGLSP--QCTCAAEGNV--VRFHCPDEYAMLLEVS 62
            ||||..::|         ...|::.:|.   ||.|  |.......|:  :|.....|.|. :|:.
Human   126 LTYLKSLYL---------DGNQLLEIPQ---GLPPSLQLLSLEANNIFSIRKENLTELAN-IEIL 177

  Fly    63 EPGAS------LYMSYYASTELQWLPRFNISSLVKIEFDAYIFWPE-KFLSDLLKTLGVQTVKTI 120
            ..|.:      .|:||                  .||.||::...: |.||  ||...|..|.|:
Human   178 YLGQNCYYRNPCYVSY------------------SIEKDAFLNLTKLKVLS--LKDNNVTAVPTV 222

  Fly   121 -------IFRDRTLETVVTRDVLN----------SGN-----------GYMETSQPENITTWHFG 157
                   ::....:...:..|..|          |||           ...:.:.|..|....|.
Human   223 LPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFD 287

  Fly   158 SVPGLKKFKFFS----HVP--------ELQE---------------SIFHGFDTLRDLHLSVN-- 193
            ::..||..:..|    |||        :|||               ...|...:|..|.||.|  
Human   288 ALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFE 352

  Fly   194 VTTLPGNM-LSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFG 257
            :.....:| ||....:||:|.     |:.....:.:||:.. |||     |.|            
Human   353 LQVYRASMNLSQAFSSLKSLK-----ILRIRGYVFKELKSF-NLS-----PLH------------ 394

  Fly   258 SMTNLEEVRLASATSSV-NRSMFKGTNKLQLI-----KMNGNDDLMEL--------------PGE 302
            ::.|||.:.|.:....: |.||||...:|::|     |::.:.|..|:              |. 
Human   395 NLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQ- 458

  Fly   303 IFLDQVNL------------------------------KTLDLSCNAIVTLHEDVFKGLGNLTLL 337
             .|:|::.                              :|||||.|:|..:....|:.|..|..|
Human   459 -VLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCL 522

  Fly   338 DLSKNRLT-NLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFY----GATL 397
            :||.|.:: .|:.:.|.||..|..|..:.|.|..:..:.|:::..|..:::.:...|    |.|.
Human   523 NLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITH 587

  Fly   398 LMNY-------EAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEEL---PDLP 452
            ::|:       :.::..:::.....|...:.:         |:.:|  :.||..|:.|   .|..
Human   588 MLNFTKNLKVLQKLMMNDNDISSSTSRTMESE---------SLRTL--EFRGNHLDVLWREGDNR 641

  Fly   453 RTTLLSTVLK-----VGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLG--------------- 497
            ...|...:||     :..|||:.||:........|:..|.|:.|.|.|..               
Human   642 YLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDL 706

  Fly   498 SGDQL---PDNLT-------HLDVRGNQIQSLSDEFL----------------LFLQEP------ 530
            |.:||   |:.|:       :|.::.|||:||:..||                ..:|:.      
Human   707 SHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENV 771

  Fly   531 -NNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIA-DIVC----TKQKKSFQQMEAF--ELC 587
             ||...|.|..|...|.|:::..:::|......:..:| |:.|    ..:.:|...::.:  ||.
Human   772 LNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELD 836

  Fly   588 PSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVS--EEELDKDKTYDAFISY 650
            .:.::|.|..:...:.::.::|..:|.|..   :| |..:.|...:.  :..:..|..|||||.|
Human   837 LTNLILFSLSISVSLFLMVMMTASHLYFWD---VW-YIYHFCKAKIKGYQRLISPDCCYDAFIVY 897

  Fly   651 SHKD----EELISKLLPKLESGPHP--FRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHF 709
            ..||    |.::::|:.|||. |..  |.|||.:||||.|..:.|.:.:::..||:.:.|::..:
Human   898 DTKDPAVTEWVLAELVAKLED-PREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKY 961

  Fly   710 IDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDSELRAYLKLNTYLKW-----GDPLF 769
            ..:...::.|.:::| .|.|::..:||:::.|.........:||..|..::.|:|     ..|.|
Human   962 AKTENFKIAFYLSHQ-RLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYF 1025

  Fly   770 WSKLYYAMPHNRRVLKGQ 787
            |..|..|:..:..|...|
Human  1026 WQCLKNALATDNHVAYSQ 1043

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TehaoNP_001285901.1 leucine-rich repeat 185..207 CDD:275380 8/24 (33%)
leucine-rich repeat 209..232 CDD:275380 6/22 (27%)
leucine-rich repeat 233..261 CDD:275380 5/27 (19%)
LRR_RI <261..370 CDD:238064 39/159 (25%)
leucine-rich repeat 262..284 CDD:275380 8/22 (36%)
leucine-rich repeat 285..309 CDD:275380 8/42 (19%)
LRR_8 309..368 CDD:290566 21/89 (24%)
leucine-rich repeat 310..333 CDD:275380 9/52 (17%)
leucine-rich repeat 334..357 CDD:275380 9/23 (39%)
leucine-rich repeat 358..381 CDD:275380 5/22 (23%)
leucine-rich repeat 445..482 CDD:275380 11/44 (25%)
LRR_8 459..516 CDD:290566 20/86 (23%)
leucine-rich repeat 483..505 CDD:275380 9/39 (23%)
LRR_4 486..521 CDD:289563 16/59 (27%)
TIR 643..779 CDD:214587 44/146 (30%)
TLR7NP_057646.1 leucine-rich repeat 598..651 CDD:275380 9/63 (14%)
LRR 21 619..644 7/35 (20%)
leucine-rich repeat 621..643 CDD:275380 6/23 (26%)
LRR 22 649..672 7/22 (32%)
leucine-rich repeat 652..676 CDD:275380 5/23 (22%)
LRR 23 674..697 6/22 (27%)
leucine-rich repeat 677..700 CDD:275380 5/22 (23%)
LRR 24 698..721 5/22 (23%)
leucine-rich repeat 701..724 CDD:275380 5/22 (23%)
LRR 25 723..745 8/21 (38%)
leucine-rich repeat 725..748 CDD:275380 8/22 (36%)
LRR 26 746..769 1/22 (5%)
leucine-rich repeat 749..767 CDD:275380 1/17 (6%)
PCC 753..>837 CDD:188093 15/83 (18%)
LRR 27 772..795 7/22 (32%)
TIR 890..>993 CDD:214587 33/104 (32%)
LRR 1 43..64
leucine-rich repeat 48..69 CDD:275380
LRR 2 65..87
LRR_8 75..139 CDD:404697 5/21 (24%)
leucine-rich repeat 91..128 CDD:275380 1/1 (100%)
LRR 3 110..126 219/993 (22%)
LRR 4 127..149 8/33 (24%)
leucine-rich repeat 129..173 CDD:275380 11/55 (20%)
LRR 5 151..170 3/18 (17%)
LRR 6 171..195 6/42 (14%)
PLN00113 191..>711 CDD:215061 119/575 (21%)
LRR 7 203..226 8/24 (33%)
leucine-rich repeat 206..225 CDD:275380 8/20 (40%)
leucine-rich repeat 227..250 CDD:275380 2/22 (9%)
LRR 8 228..247 1/18 (6%)
LRR 9 248..275 3/26 (12%)
leucine-rich repeat 251..291 CDD:275380 6/39 (15%)
LRR 10 289..312 6/22 (27%)
leucine-rich repeat 292..315 CDD:275380 6/22 (27%)
LRR 11 314..337 3/22 (14%)
leucine-rich repeat 316..341 CDD:275380 4/24 (17%)
LRR 12 339..368 8/28 (29%)
leucine-rich repeat 342..371 CDD:275380 9/28 (32%)
LRR 13 369..392 9/33 (27%)
leucine-rich repeat 372..398 CDD:275380 9/48 (19%)
LRR 14 396..419 8/22 (36%)
leucine-rich repeat 399..422 CDD:275380 8/22 (36%)
LRR 15 421..443 5/21 (24%)
LRR <488..775 CDD:227223 65/297 (22%)
LRR 16 492..515 8/22 (36%)
leucine-rich repeat 496..518 CDD:275380 9/21 (43%)
LRR 17 516..540 8/23 (35%)
leucine-rich repeat 519..543 CDD:275380 9/23 (39%)
LRR 18 541..564 6/22 (27%)
leucine-rich repeat 544..567 CDD:275380 5/22 (23%)
LRR 19 566..588 4/21 (19%)
leucine-rich repeat 568..597 CDD:275380 5/28 (18%)
LRR 20 595..618 1/22 (5%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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