DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tollo

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	978	Identity:	241/978 - (24%)
Similarity:	397/978 - (40%)	Gaps:	291/978 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LEVSEPG-----ASLYMSYYASTEL--QWLPRFNISSLVKIE--------------FDAYIFWPE 102
            :.|..||     |.|.:...||.||  ||:   |.::.|.::              .:|:||.|.
  Fly   294 INVLAPGIFGELAELLVLDLASNELNSQWI---NAATFVGLKRLMMLDLSANKISRLEAHIFRPL 355

  Fly   103 KFLSDL-LKTLGVQTVKTIIFRDRT-LETVVTRDVLNSGNGYMETSQPENITTWHFGSVPGLKKF 165
            ..|..| |:...:..:...||.|.| |.|::.     |.|         .|:.....::.|||..
  Fly   356 ASLQILKLEDNYIDQLPGGIFADLTNLHTLIL-----SRN---------RISVIEQRTLQGLKNL 406

  Fly   166 KF----FSHVPELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPL 226
            ..    |:.:..:.:........|:||||:.|........|:.|. .||||.:....|....|..
  Fly   407 LVLSLDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQ-LLKTLDVGENMISQIENTS 470

  Fly   227 LRELQQLRNLSL---ALIHPFHERDKQLQPHFFGSMTNLEEVRLA-SATSSVNRSMFKGTNKLQL 287
            :.:|:.|..|.:   :|.|        ::...|..|::|:.:.|: :...|:.....:..::||.
  Fly   471 ITQLESLYGLRMTENSLTH--------IRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQA 527

  Fly   288 IKMNGND------DLMELPGEIFLD--------------QVNLKTLDLSCNAIVTLHEDVFKGLG 332
            |:::||.      ...|||..::|:              .:.|:.||:..|.|..        ||
  Fly   528 IRLDGNQLKSIAGLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQ--------LG 584

  Fly   333 N---------LTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVF--------QDVV 380
            |         |:..|.|.|.||.::::...  .|:.||.||.|.::.:.|..|        .|:|
  Fly   585 NYFEIESELSLSTFDASYNLLTEITASSIP--NSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLV 647

  Fly   381 -------------------------------------SLNYIEMVNTQFYGATLLMNYEAVVC-- 406
                                                 :|::::.||.:......||:.:.:.|
  Fly   648 RNRLTTLEPNALRLSPIAEDREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRL 712

  Fly   407 ---------------TNDEACQYKS---------------AEWQCDPRCICWVQRSVGSLIVDCR 441
                           ::|..|:|.|               .:.:|..||.|:..:|..|.:|||.
  Fly   713 AYARGSSHVSLIEAKSDDFLCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCS 777

  Fly   442 GTSLEE-LPD-LPRTTLLSTVLKVGNNSLTSLPTVS------------EHS-----------GYA 481
            ..|.|: ||. :|   :.||.|.:..|:...|.:.:            .||           |..
  Fly   778 RASYEQTLPSHIP---MDSTQLYLDGNNFRELQSHAFIGRKRLKVLHLNHSRIEVLHNRTFYGLL 839

  Fly   482 NVSGLFLSDNNLTSL-GSGDQLPDNLTHLDVRGNQIQSLSD------EFLLFLQEPNNTMT---- 535
            .:..|.|..|.|.:| |:..|..|||..|.::.|.|.::..      ..|..|:..:|.:|
  Fly   840 ELEVLQLQSNQLKALNGNEFQGLDNLQELYLQHNAIATIDTLTFTHLYHLKILRLDHNAITSFAV 904

  Fly   536 ----------LSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVC------------------- 571
                      |.|:.||.||.||.:..|.......:.|.|...:.|
  Fly   905 WNFLPSYLNELRLASNPWTCSCEFIDKLRDYINRHEYVVDKLKMKCDVISGNSTQQMVIYPGSGE 969

  Fly   572 -----------------------------------TKQKKSFQQMEAFELCPSYVLLISCVVGGL 601
                                               |..|....|....:..|   :|::.:...:
  Fly   970 PASLPVVQCSQTLPLGLDNNFNYAEQAGGENASNATSTKMILNQPPKLDYIP---ILVAILTAFI 1031

  Fly   602 VIVICLLTVFYLMFQQELKIWLYNN-NLCLWWVSEEELDK---DKTYDAFISYSHKDEELIS-KL 661
            .::||:..||  :|:||:::|.::. .:.|::.:::::||   :|.:|||:|||.|||..:: :|
  Fly  1032 FVMICISLVF--IFRQEMRVWCHSRFGVRLFYNAQKDVDKNEREKLFDAFVSYSSKDELFVNEEL 1094

  Fly   662 LPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQAT 726
            .|.||.|.|.::||||.||:.||..:||.||:.:|.|:|.|:|:|::||.|.|.|.||:.|:|:.
  Fly  1095 APMLEMGEHRYKLCLHQRDFPVGGYLPETIVQAIDSSRRTIMVVSENFIKSEWCRFEFKSAHQSV 1159

  Fly   727 LQDKRKRIIIILYRELEHMNGIDSELRAYLKLNTYLKWGDPLFWSKLYYAMP----HNRRVLKGQ 787
            |:|:|:|:|:|:..|:.... :|.:||.|||.||||:|||.|||.||.:|:|    ..|..:.||
  Fly  1160 LRDRRRRLIVIVLGEVPQKE-LDPDLRLYLKTNTYLQWGDKLFWQKLRFALPDVSSSQRSNVAGQ 1223

  Fly   788 KKH 790
            ..|
  Fly  1224 SCH 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/21 (38%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..261	CDD:275380	6/30 (20%)
		LRR_RI	<261..370	CDD:238064	32/138 (23%)
		leucine-rich repeat	262..284	CDD:275380	3/22 (14%)
		leucine-rich repeat	285..309	CDD:275380	9/43 (21%)
		LRR_8	309..368	CDD:290566	20/67 (30%)
		leucine-rich repeat	310..333	CDD:275380	6/22 (27%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	9/67 (13%)
		leucine-rich repeat	445..482	CDD:275380	12/61 (20%)
		LRR_8	459..516	CDD:290566	19/80 (24%)
		leucine-rich repeat	483..505	CDD:275380	7/22 (32%)
		LRR_4	486..521	CDD:289563	13/35 (37%)
		TIR	643..779	CDD:214587	69/140 (49%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064
		leucine-rich repeat	100..123	CDD:275380
		leucine-rich repeat	124..144	CDD:275380
		LRR_8	152..222	CDD:290566
		leucine-rich repeat	154..177	CDD:275380
		leucine-rich repeat	178..201	CDD:275380
		LRR	210..656	CDD:227223	90/397 (23%)
		leucine-rich repeat	212..235	CDD:275380
		leucine-rich repeat	236..259	CDD:275380
		leucine-rich repeat	260..283	CDD:275380
		LRR_RI	276..558	CDD:238064	66/289 (23%)
		leucine-rich repeat	284..307	CDD:275380	3/12 (25%)
		leucine-rich repeat	308..333	CDD:275380	9/27 (33%)
		leucine-rich repeat	334..357	CDD:275380	4/22 (18%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	382..405	CDD:275380	7/36 (19%)
		leucine-rich repeat	406..429	CDD:275380	1/22 (5%)
		leucine-rich repeat	430..452	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..500	CDD:275380	13/54 (24%)
		leucine-rich repeat	501..521	CDD:275380	3/19 (16%)
		leucine-rich repeat	525..547	CDD:275380	7/21 (33%)
		leucine-rich repeat	548..573	CDD:275380	2/24 (8%)
		leucine-rich repeat	604..640	CDD:275380	10/37 (27%)
		leucine-rich repeat	641..688	CDD:275380	3/46 (7%)
		leucine-rich repeat	689..816	CDD:275380	28/129 (22%)
		LRR_8	815..875	CDD:290566	15/59 (25%)
		leucine-rich repeat	817..864	CDD:275380	10/46 (22%)
		LRR_8	864..921	CDD:290566	11/56 (20%)
		leucine-rich repeat	865..888	CDD:275380	4/22 (18%)
		leucine-rich repeat	889..910	CDD:275380	4/20 (20%)
		TIR	1076..1211	CDD:214587	68/135 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25481
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	6	5.820