DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tl

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	993	Identity:	275/993 - (27%)
Similarity:	421/993 - (42%)	Gaps:	296/993 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 CTCAAEGNVVRFHC-PDEYAMLLEVSEPGASLYMSYYASTELQWLP-RFNISSLVKIEFDAYIFW 100
            |...||....|... |.:|..::          .:...:|:.|.|| :..|..:.:::....:..
  Fly    56 CPANAENPTFRLTIQPKDYVQIM----------CNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLP 110

  Fly   101 PEKFLSDLLKTLGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQPENITTWHFGSVPGLKKF 165
            ....::.:|..||:.:..|:||....|..                    |||..|...:.|||:|
  Fly   111 GHTPIASILDYLGIVSPTTLIFESDNLGM--------------------NITRQHLDRLHGLKRF 155

  Fly   166 KF----FSHVPELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPL 226
            :|    .:|:|   .::......|..|.|..|:..:|.::...:.      .:||   :.||:..
  Fly   156 RFTTRRLTHIP---ANLLTDMRNLSHLELRANIEEMPSHLFDDLE------NLES---IEFGSNK 208

  Fly   227 LREL------------------QQLRNLSLALIHPF-----------HERDKQLQPH-FFGSMTN 261
            ||::                  .||.||:.   |.|           |:...:..|| .|..:||
  Fly   209 LRQMPRGIFGKMPKLKQLNLWSNQLHNLTK---HDFEGATSVLGIDIHDNGIEQLPHDVFAHLTN 270

  Fly   262 ------------------------LEEVRLAS---ATSSVNRSMFKGTNKLQLIKMNGNDDLMEL 299
                                    |.||||.:   ..:::...:|....:||::::..  :|..|
  Fly   271 VTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRA--ELQSL 333

  Fly   300 PGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLN 364
            ||::|.....:..:.|..|.:.||...:.:...||..||||.||||:|..::||..|:|..|||.
  Fly   334 PGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLE 398

  Fly   365 KNSLTAMSPSVFQD-------VVSLNYIEMVNTQFYGAT-------------------------- 396
            .|.||.:|..:|.:       |:|.|.:..::::.:.:|
  Fly   399 DNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQT 463

  Fly   397 ------------LLMN----------------------------------YE------------- 402
                        |.:|                                  ||
  Fly   464 QINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVN 528

  Fly   403 ---------------------------------AVVC--------------------------TN 408
                                             .:||                          |:
  Fly   529 MTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTD 593

  Fly   409 DEACQYKSA------------------EWQCDPR-------CICWVQRSVGSLIVDCRGTSLEEL 448
            ...|...:.                  ::..|||       |.|.|:....:|:::|...:|..:
  Fly   594 RLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHV 658

  Fly   449 PDLP--RTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDV 511
            |.||  ...:....|.:.||:|..||:.:. .||.:|:.|.|:.|||||: ..||||.||||||:
  Fly   659 PRLPNLHKNMQLMELHLENNTLLRLPSANT-PGYESVTSLHLAGNNLTSI-DVDQLPTNLTHLDI 721

  Fly   512 RGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVCTKQKK 576
            ..|.:|.|:...|.||.......::.|||||..|.|.:..||.|.:.|.:|:.|..:::|...:.
  Fly   722 SWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEM 786

  Fly   577 SFQQME--AFELCPSY--VLLISCVVGGLVIVICLLT-VFYLMFQQELKIWLYNNNLCLWWVSEE 636
            ..:.:|  ..::||:.  |.:...||..|..::...| ..|..||.|:|||||.:||.||:|:||
  Fly   787 PTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEE 851

  Fly   637 ELDKDKTYDAFISYSHKDEELISK-LLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKR 700
            :|||||.:||||||||||:..|.. |:|:||.||..|:||:|:||||||..|||.|:|:|.||:|
  Fly   852 DLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRR 916

  Fly   701 VIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDSELRAYLKLNTYLKWG 765
            .||||||:||.|.|||:|||.|:::.|.:.|.|||:|:|.::..:..:|.||:||||:|||||||
  Fly   917 TIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWG 981

  Fly   766 DPLFWSKLYYAMPHNRRV 783
            ||.||.||.:|:||.|.|
  Fly   982 DPWFWDKLRFALPHRRPV 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	5/21 (24%)
		leucine-rich repeat	209..232	CDD:275380	6/40 (15%)
		leucine-rich repeat	233..261	CDD:275380	9/39 (23%)
		LRR_RI	<261..370	CDD:238064	38/135 (28%)
		leucine-rich repeat	262..284	CDD:275380	6/24 (25%)
		leucine-rich repeat	285..309	CDD:275380	7/23 (30%)
		LRR_8	309..368	CDD:290566	23/58 (40%)
		leucine-rich repeat	310..333	CDD:275380	4/22 (18%)
		leucine-rich repeat	334..357	CDD:275380	12/22 (55%)
		leucine-rich repeat	358..381	CDD:275380	10/29 (34%)
		leucine-rich repeat	445..482	CDD:275380	12/38 (32%)
		LRR_8	459..516	CDD:290566	27/56 (48%)
		leucine-rich repeat	483..505	CDD:275380	12/21 (57%)
		LRR_4	486..521	CDD:289563	20/34 (59%)
		TIR	643..779	CDD:214587	80/136 (59%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	11/67 (16%)
		leucine-rich repeat	176..198	CDD:275380	5/27 (19%)
		leucine-rich repeat	199..222	CDD:275380	6/25 (24%)
		LRR_RI	216..542	CDD:238064	60/330 (18%)
		LRR_8	221..281	CDD:290566	12/62 (19%)
		leucine-rich repeat	223..270	CDD:275380	10/49 (20%)
		leucine-rich repeat	271..294	CDD:275380	0/22 (0%)
		leucine-rich repeat	295..320	CDD:275380	6/24 (25%)
		leucine-rich repeat	321..343	CDD:275380	7/23 (30%)
		LRR_8	342..402	CDD:290566	23/59 (39%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	12/22 (55%)
		LRR_8	390..450	CDD:290566	14/59 (24%)
		leucine-rich repeat	392..415	CDD:275380	9/22 (41%)
		leucine-rich repeat	416..439	CDD:275380	4/22 (18%)
		leucine-rich repeat	440..474	CDD:275380	0/33 (0%)
		leucine-rich repeat	475..498	CDD:275380	2/22 (9%)
		LRR_8	477..534	CDD:290566	3/56 (5%)
		leucine-rich repeat	499..520	CDD:275380	2/20 (10%)
		leucine-rich repeat	523..552	CDD:275380	0/28 (0%)
		LRRCT	561..619	CDD:214507	4/57 (7%)
		LRRNT	631..667	CDD:214470	9/35 (26%)
		leucine-rich repeat	664..693	CDD:275380	8/29 (28%)
		LRR_8	669..726	CDD:290566	27/58 (47%)
		leucine-rich repeat	694..715	CDD:275380	12/21 (57%)
		leucine-rich repeat	716..737	CDD:275380	9/20 (45%)
		LRRCT	751..800	CDD:214507	12/48 (25%)
		TIR	858..996	CDD:214587	81/137 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I3869
Isobase	1	0.950	-	0	Normalized mean entropy	S8062
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	1	1.000	-	-		otm25481
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	10	9.920