DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr19.1

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	905	Identity:	187/905 - (20%)
Similarity:	324/905 - (35%)	Gaps:	286/905 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YMSYYASTELQWLPR--------------FNISSLVKIEFDAYIFWPEKFL--SDLLKTL----- 112
            |:|...|.||..|.|              .:::.|:.:...:.||.|...|  .|:::|.
Zfish   129 YLSMLFSDELYRLVRIDNRSFAGLNNLEELSLTGLMLLNGSSGIFDPLVSLIRLDIVRTCAQDLG 193

  Fly   113 --------GVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQPENITTWHFGSVPGLKK-FKFF 168
                    |:..::.:...|..:.|:..:..            |....||...::.|::. :...
Zfish   194 EIFCCISNGMTRLRHLNVEDSEISTIENKGC------------PGGSMTWPLTALSGVQNLYLIG 246

  Fly   169 SHVPELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFG---NPLLREL 230
            :::..:|.:....|..|..|.|.....:| |::..:..|.:..||::...:..:.   ..|...:
Zfish   247 NNIKYIQANSLIIFQNLSSLFLEFEGKSL-GSIWESGVGKVNDLTLKGKVLKKYSTNFKDLCHLV 310

  Fly   231 QQLRNLSLALIHPFHER----------------------DKQLQPHFFGSMTNLEEVRLA--SAT 271
            ..|.:.||:|::...:|                      ...|...|:.|...::.:::|  ..|
Zfish   311 SSLYSQSLSLVYTSIDRLTAEDLKDCGTKLTKLLIQNSKIDNLDFRFWTSKLEMQALQMAYMKLT 375

  Fly   272 SS-----VNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGL 331
            .:     .|.:|:..|:    :.:.|| .:..:.|:.|.....|:.|.||.|||.||....|:||
Zfish   376 DAPFCFVANSTMWSLTS----LDLTGN-SITNIEGDQFACMPFLEQLYLSQNAIKTLQLHAFRGL 435

  Fly   332 GNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGAT 396
            ..|.:|.|..|::..||:..|..|.:|.||.:|.|.:..:....|
Zfish   436 PRLKILQLDSNKIWQLSANDFKNLRALEVLLINDNIIETIETGTF-------------------- 480

  Fly   397 LLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSL----IVDCRGTSLEELPDLPRTTL- 456
                                  |  |.|.:|  :.|.|.|    .:.......|..|.|.|.::
Zfish   481 ----------------------W--DQRELC--ELSFGRLEYVYELHLENIFFEFPPKLQRLSID 519

  Fly   457 --LSTVLKVGN----NSLTSLPTVSEHSGY---------------ANVSGLFLSDN-------NL 493
              ..|.:.:||    |...:|....|..|:               .|.:.....|:       ||
Zfish   520 AHYGTNIYIGNASPPNGTFALELNGERLGFVGCDSDVLMAVRELKVNCTYFLCKDSFMAPYFLNL 584

  Fly   494 TSL---GSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNT---------------------- 533
            .||   |..::.|.|...:    |.:..|....|..|..||.|
Zfish   585 ESLEISGGAERAPLNYATI----NNLHHLKHLKLARLNFPNYTESRSAFWNLTQLQTLVVVNCHL 645

  Fly   534 --MTLSL-------------SGNPI-----------------------TCGCESLSLLFFVRTNP 560
              :|.|:             |.:|:                       .|.||:..||.:. .:.
Zfish   646 SFLTKSMFRDLTSLQLLRLYSDSPLILTDGVFGVLPVLKAFILDRVDFQCSCENGWLLDWA-DST 709

  Fly   561 QRVRDI----ADIVCTKQKKSFQ-------QMEAFELC-----PSYVLLISCVVG-------GLV 602
            ::|:.|    ...|...||.:|.       |.:|..:|     .|..||:|..||       .||
Zfish   710 EKVQVIYLQKQQCVWHYQKLNFLATMEKLCQTDAQYICYVATASSISLLLSAAVGYQFARWPSLV 774

  Fly   603 IVICLLTVFYLMFQQELKIWLYNNNLCLWWVSEEELDKD------KTYDAFISYSHKDEE-LISK 660
            :.:            .||.|:.......|......::.|      ..||||:|:..:||. ::.:
Zfish   775 LFL------------RLKGWMERRFGRRWNRRRRRMEDDYGEIEEMQYDAFVSFCSQDEAWVLGE 827

  Fly   661 LLPKLESGPHP-FRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQ 724
            :..:||...:| .|||||:||:.||..|.:.|..::.:|:..:.::|:.::.|.|..:|.|:|..
Zfish   828 MASRLEEQGNPRLRLCLHNRDFEVGKDIMDNITDSIHNSQCTVCLISRRYLRSDWCGLEMRVATH 892

  Fly   725 ATLQDKRKRIIIILYRELEHMNGIDSELRAYLKL------NTYLKW----GD-PLFWSKL 773
            ..|::::.|:|:|.   |:|::..  ||.|:.:|      .|||.|    || ..||.:|
Zfish   893 RQLEEQKHRLILIF---LQHISPF--ELSAFHRLAKLVRSRTYLDWPEEEGDREHFWDRL 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	5/21 (24%)
		leucine-rich repeat	209..232	CDD:275380	3/25 (12%)
		leucine-rich repeat	233..261	CDD:275380	8/49 (16%)
		LRR_RI	<261..370	CDD:238064	34/115 (30%)
		leucine-rich repeat	262..284	CDD:275380	5/28 (18%)
		leucine-rich repeat	285..309	CDD:275380	4/23 (17%)
		LRR_8	309..368	CDD:290566	25/58 (43%)
		leucine-rich repeat	310..333	CDD:275380	12/22 (55%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	445..482	CDD:275380	11/58 (19%)
		LRR_8	459..516	CDD:290566	17/85 (20%)
		leucine-rich repeat	483..505	CDD:275380	7/31 (23%)
		LRR_4	486..521	CDD:289563	10/44 (23%)
		TIR	643..779	CDD:214587	47/144 (33%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378	7/32 (22%)
		leucine-rich repeat	103..126	CDD:275380
		leucine-rich repeat	127..154	CDD:275380	7/24 (29%)
		leucine-rich repeat	155..178	CDD:275380	4/22 (18%)
		leucine-rich repeat	179..238	CDD:275380	9/70 (13%)
		leucine-rich repeat	207..219	CDD:275378	1/11 (9%)
		leucine-rich repeat	239..265	CDD:275380	3/25 (12%)
		leucine-rich repeat	340..363	CDD:275380	3/22 (14%)
		leucine-rich repeat	364..389	CDD:275380	4/24 (17%)
		LRR_8	389..448	CDD:316378	21/63 (33%)
		leucine-rich repeat	390..413	CDD:275378	5/27 (19%)
		leucine-rich repeat	414..437	CDD:275378	12/22 (55%)
		LRR_8	436..>482	CDD:316378	15/89 (17%)
		leucine-rich repeat	438..461	CDD:275378	8/22 (36%)
		leucine-rich repeat	462..485	CDD:275378	8/66 (12%)
		leucine-rich repeat	540..562	CDD:275380	3/21 (14%)
		leucine-rich repeat	563..608	CDD:275380	10/48 (21%)
		leucine-rich repeat	609..634	CDD:275380	6/24 (25%)
		leucine-rich repeat	635..658	CDD:275380	2/22 (9%)
		TIR	809..952	CDD:214587	47/144 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010