DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr9

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001124066.1	Gene:	tlr9 / 403128	ZFINID:	ZDB-GENE-040219-10	Length:	1057	Species:	Danio rerio

Alignment Length:	880	Identity:	190/880 - (21%)
Similarity:	309/880 - (35%)	Gaps:	297/880 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NVVRFHCPDEYAMLLEVSEPGASLYMSYYASTELQWLPRF--------NISSLVKIEFDAYIFWP 101
            |||..:....|..|....|...|.|:...||....:|..|        :|:.|||:.....:...
Zfish   329 NVVILNLLYNYEPLKTFPELNLSPYIEKMASLRELYLSGFFFKKLSNRSIAPLVKLPRLEVLDLR 393

  Fly   102 EKFLSDL-------LKTL-GVQTVKTIIFRDRTLETVVTR---------------------DVLN 137
            ..|:.|:       |:|| .|...:.::.......|..:.                     .:||
Zfish   394 MNFICDISIDGLSQLRTLRRVDLSQNMLAFSSCFSTCTSEAEHQIPERYGNEQFNLQMQELPILN 458

  Fly   138 SGNGYMET--SQPE----NITTWHFGSVPGLKKFKF---FSHVPELQESIFHGFDTLRDLHLSVN 193
            :     ||  |:|:    ..:.|||......|...|   .:::|.|..|.|.|.|.:..:.||.|
Zfish   459 A-----ETQGSKPDYCSFYFSMWHFKRQICSKSLYFDLSQNNIPWLNASTFRGMDRVACVDLSYN 518

  Fly   194 V--TTLPGNMLS------------------------TVNGTLKTLTIESPGIVSFGNPLLRELQQ 232
            .  .||.|:..|                        .|:||||.|.:.:
Zfish   519 YISQTLNGHQFSHLSKLSYLNMAYNRIDLYSDKAFQEVSGTLKALDLSN---------------- 567

  Fly   233 LRNLSLALIHPFHERDKQLQPHFFGSMTNLEEVRLASATSSVNRSMFKGTNKLQLIKMNGNDDLM 297
                     :.||...|.: .|.|..:|::..:.:.|..:          |.:.|...|
Zfish   568 ---------NEFHFIMKGM-GHQFTFLTHMSSLIILSLAN----------NHIGLRISN------ 606

  Fly   298 ELPGEIFLDQVNLKTLDLSCNAIVTLHE-------DVFKGLGNLTLLDLSKNRLTNLSSTIFAPL 355
                  .|...:||.|..|.|.:..|.:       ::|:||.|||.||:|:|:|.:||..:...|
Zfish   607 ------ILTSASLKYLIFSGNRLDILWDSWRNQYINLFQGLTNLTHLDISENQLKSLSPEVIVNL 665

  Fly   356 -TSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYKSAEW 419
             .||.|||::.|.||...
Zfish   666 PLSLQVLRVDFNMLTYFP----------------------------------------------- 683

  Fly   420 QCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVS 484
                    |...||           |::|          ..|.:.:|.|:.||.::..   ..::
Zfish   684 --------WANISV-----------LQKL----------CYLNLSSNMLSYLPNINFE---LRLT 716

  Fly   485 GLFLSDNNLTSLGSGDQLPD-------NLTHLDVRGNQIQSLSDEFL--------LFL---QEPN 531
            ||.||.|.|.:      :|.       ||.:|::..||::.|..:.|        .|:   |..|
Zfish   717 GLDLSHNRLVA------IPKVFLSQAANLKNLNLNNNQLKILDVQALPLPFHKGCTFIPGGQHKN 775

  Fly   532 -NTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLIS 595
             ::..|.|..||.||.|.......|:|.....|..:...|.....:|...:....     |.|.|
Zfish   776 RSSCKLVLHANPFTCSCVISGFAKFLRETDLDVPHLTTQVHCGFPESLAGVNVLS-----VDLRS 835

  Fly   596 C--VVGGLVIVIC--LLTV--FYLMFQQELKIWLYNNNLCLWWVSE------------EELDKDK 642
            |  :.|| |..:|  |||:  ..:...:.|..|      .||::.:            .....|.
Zfish   836 CQEIFGG-VAFLCTSLLTLAATCVPLLKHLYGW------DLWYLIQILWTGHRGHTPANGNPTDT 893

  Fly   643 TYDAFISYSHKDEE----LISKLLPKLES-GPHPFRLCLHDRDWLVG-DCIPEQIVRTVDDSKRV 701
            .||||:.:...::.    :..::|.:||: |...|:|||.:|||:.| .|| |.:.::|..|::.
Zfish   894 QYDAFVVFDTSNKAVRDWIYKEMLVRLENRGRWRFQLCLEERDWIPGVSCI-ENLHKSVYSSRKT 957

  Fly   702 IIVLSQ--HFID-SVWARMEFRIAYQATLQDKRKRIIII----LYRELEHMNGIDSELRAYLKLN 759
            :.||:.  .:.| |...|..|.:..|..|.:|....:::    |:.:.:::     ::|..|...
Zfish   958 VFVLTSPGGYSDASGIVRQAFLLVQQRLLDEKVDVAVLVLLDFLFPKFKYL-----QMRKRLCKK 1017

  Fly   760 TYLKWG-----DPLFWSKLYYAM------PHNRRV 783
            :.|.|.     .||||:.|..|:      .:|:.|
Zfish  1018 SVLSWPRNPRVQPLFWNDLRVALVSDNVRAYNKNV 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/47 (17%)
		leucine-rich repeat	209..232	CDD:275380	3/22 (14%)
		leucine-rich repeat	233..261	CDD:275380	5/27 (19%)
		LRR_RI	<261..370	CDD:238064	32/116 (28%)
		leucine-rich repeat	262..284	CDD:275380	1/21 (5%)
		leucine-rich repeat	285..309	CDD:275380	3/23 (13%)
		LRR_8	309..368	CDD:290566	26/66 (39%)
		leucine-rich repeat	310..333	CDD:275380	9/29 (31%)
		leucine-rich repeat	334..357	CDD:275380	10/23 (43%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	445..482	CDD:275380	7/36 (19%)
		LRR_8	459..516	CDD:290566	16/63 (25%)
		leucine-rich repeat	483..505	CDD:275380	7/28 (25%)
		LRR_4	486..521	CDD:289563	12/41 (29%)
		TIR	643..779	CDD:214587	41/159 (26%)
tlr9	NP_001124066.1	leucine-rich repeat	39..57	CDD:275380
		LRR_8	56..129	CDD:290566
		leucine-rich repeat	58..81	CDD:275380
		LRR_RI	<73..312	CDD:238064
		leucine-rich repeat	82..118	CDD:275380
		leucine-rich repeat	119..138	CDD:275380
		leucine-rich repeat	139..192	CDD:275380
		LRR_8	191..246	CDD:290566
		leucine-rich repeat	193..213	CDD:275380
		leucine-rich repeat	214..237	CDD:275380
		leucine-rich repeat	238..279	CDD:275380
		LRR_RI	274..>422	CDD:238064	22/92 (24%)
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..323	CDD:275380
		leucine-rich repeat	360..386	CDD:275380	6/25 (24%)
		leucine-rich repeat	387..408	CDD:275380	2/20 (10%)
		LRR_8	490..545	CDD:290566	13/54 (24%)
		leucine-rich repeat	490..509	CDD:275380	5/18 (28%)
		leucine-rich repeat	510..534	CDD:275380	7/23 (30%)
		leucine-rich repeat	535..559	CDD:275380	1/23 (4%)
		leucine-rich repeat	560..589	CDD:275380	9/54 (17%)
		leucine-rich repeat	590..612	CDD:275380	5/43 (12%)
		LRR_8	612..679	CDD:290566	26/66 (39%)
		leucine-rich repeat	613..643	CDD:275380	9/29 (31%)
		leucine-rich repeat	644..668	CDD:275380	10/23 (43%)
		leucine-rich repeat	669..692	CDD:275380	11/88 (13%)
		leucine-rich repeat	693..714	CDD:275380	6/33 (18%)
		TIR_2	894..1040	CDD:304906	40/151 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820