DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr2

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_005170910.1	Gene:	tlr2 / 403125	ZFINID:	ZDB-GENE-040219-6	Length:	818	Species:	Danio rerio

Alignment Length:	709	Identity:	162/709 - (22%)
Similarity:	277/709 - (39%)	Gaps:	184/709 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 NGYMETSQPENITTWHFGSVPGLKKFKFFSHVPELQESIFHGF---DTL---RDLHLSVNVTTLP 198
            ||.::.::|       .||| .|.....|...|||...:....   :||   :|:.:..|.:|.|
Zfish   218 NGSLKAARP-------IGSV-SLSLQNLFESDPELVSKVLQDVSHPETLLIIKDVTMKTNTSTEP 274

  Fly   199 GNMLSTVNGTLKTLTIES-----PGIVSF-----GNPL------------LRELQQLRNLSLALI 241
            ..|:.  .|..|:||.::     ..:.||     |:||            :.|.|:.:......:
Zfish   275 FKMVK--EGGTKSLTFQNSSTTDQALTSFLEFMDGSPLSFIGLEDIQFVGIGEWQKAKYTHHDSL 337

  Fly   242 HPFHERDKQLQPHF-FGSMTNLEEVRLASATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFL 305
            ...:.|:.:::..| |.||..|             ..:.|..:.:.:|    |..:..:|.|...
Zfish   338 RTAYLRNIEIEGFFGFSSMIEL-------------GFLLKHFHNVSVI----NATVFVIPKETTF 385

  Fly   306 DQVNLKTLDLSCNAI--VTLHEDVFKGLG---NLTLLDLSKNRLTNLS--STIFAPLTSLNVLRL 363
            ...||:.:|||.|.:  :|:...::.|.|   ||.:|::|:|.|.:|.  |.:...|..|..|.|
Zfish   386 LLKNLEYMDLSQNLLTDLTIQPTLYTGSGAYQNLNMLNVSQNVLKSLGLMSRLVTNLKKLKYLDL 450

  Fly   364 NKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICW 428
            :.||..:| |......|:|.::.:.:|:.
Zfish   451 SYNSFVSM-PEKCSWPVTLRFLNLSSTKL------------------------------------ 478

  Fly   429 VQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNL 493
                  |.:..|..:||             |||.:..|.|.:.     ...:.:::.|.|:.|.|
Zfish   479 ------STLTPCLPSSL-------------TVLDLSENDLKAF-----KQRFPHLTTLILTGNRL 519

  Fly   494 TSLGSGDQLPDNLTHLDVRG-----NQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLL 553
            ..|..|...|...|.|..|.     ||....|.:.||:|:         ...|...|.|:.:|
Zfish   520 MKLPDGKLFPSLNTLLIQRNALRMFNQSSLRSFKTLLYLE---------AGANNFVCSCKFVS-- 573

  Fly   554 FFVRTNPQRVRDIADIVCTKQKK----------------SFQQMEAFE--LCPSYVLLISCVVG- 599
            ||       .:|:.|::..:..:                ...::..||  :.|:..:|...::.
Zfish   574 FF-------KKDVEDLITLQDGRQNYVCNTPFTLRGNAIDSVRLSVFECYMIPAVSVLCFGIITA 631

  Fly   600 -GLVIVIC--LLTVFYLMFQQELKIWLYNNNLCLWWVSEEELDKDKTYDAFISYSHKDEELISKL 661
             |||::.|  |..::||   |..|.|:.....    .:...|.::..||||:|||..|.|.:.::
Zfish   632 LGLVVLTCHKLHVIWYL---QMTKAWIQAKRK----PAVGRLPEELRYDAFVSYSQHDAEWVEEI 689

  Fly   662 L-PKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQA 725
            | .:||.....|.||||.||:..|..|.:.|:.:::.|.|.:.|||:||:.|.|.|.|...::..
Zfish   690 LVAELEDTQPSFSLCLHKRDFRPGRWIVDNIIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFR 754

  Fly   726 TLQDKRKRIIIILYREL--EHMNGIDSELRAYLKLNTYLKWGD-----PLFWSKLYYAM 777
            .:.:.....:::|...:  |.:.....:||..:...|||:|.:     ..|||.|..|:
Zfish   755 IMDEHNDSAVLVLLEPIKKETIPKRFCKLRKIMNSRTYLEWPEDEDKRDEFWSNLRAAL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/24 (25%)
		leucine-rich repeat	209..232	CDD:275380	9/44 (20%)
		leucine-rich repeat	233..261	CDD:275380	5/28 (18%)
		LRR_RI	<261..370	CDD:238064	29/115 (25%)
		leucine-rich repeat	262..284	CDD:275380	2/21 (10%)
		leucine-rich repeat	285..309	CDD:275380	4/23 (17%)
		LRR_8	309..368	CDD:290566	22/65 (34%)
		leucine-rich repeat	310..333	CDD:275380	8/27 (30%)
		leucine-rich repeat	334..357	CDD:275380	8/24 (33%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	445..482	CDD:275380	6/36 (17%)
		LRR_8	459..516	CDD:290566	16/61 (26%)
		leucine-rich repeat	483..505	CDD:275380	7/21 (33%)
		LRR_4	486..521	CDD:289563	12/39 (31%)
		TIR	643..779	CDD:214587	46/143 (32%)
tlr2	XP_005170910.1	leucine-rich repeat	85..105	CDD:275378
		leucine-rich repeat	106..129	CDD:275378
		LRR_8	108..163	CDD:290566
		leucine-rich repeat	130..153	CDD:275378
		leucine-rich repeat	154..178	CDD:275378
		leucine-rich repeat	179..192	CDD:275378
		LRR_RI	<390..501	CDD:238064	36/166 (22%)
		leucine-rich repeat	390..418	CDD:275380	8/27 (30%)
		LRR_8	418..478	CDD:290566	19/60 (32%)
		leucine-rich repeat	419..444	CDD:275380	8/24 (33%)
		leucine-rich repeat	445..467	CDD:275380	7/22 (32%)
		leucine-rich repeat	468..488	CDD:275380	4/61 (7%)
		leucine-rich repeat	489..508	CDD:275380	6/36 (17%)
		leucine-rich repeat	509..530	CDD:275380	6/20 (30%)
		leucine-rich repeat	531..554	CDD:275380	6/22 (27%)
		TIR	671..814	CDD:214587	46/143 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7248
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920