Protein Alignment Tehao and tlr21

DIOPT Version :10

• Sequence 1: NP_477438.1
• Gene: Tehao / 34761
• FlyBaseID: FBgn0026760
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_001186264.2
• Gene: tlr21 / 402884
• ZFINID: ZDB-GENE-040220-4
• Length: 989
• Species: Danio rerio
• Alignment Length: 875
• Identity: 206/875 - (23%)
• Similarity: 340/875 - (38%)
• Gaps: 230/875 - (26%)

  Fly    52 PDEYAM-------LLEVSEPGASLYMSYYAS-TELQWLPRFNIS--SLVKIEFDAYIFWPEK--- 103
            ||||..       :|::.......:.|...| |.|..|.:.::|  .|..::...::  ||.
Zfish   147 PDEYLFSSLTNLKILDLRRNHLYNFSSVVESITNLTSLIKLDLSFNKLTTLQHSTHL--PESLAL 209

  Fly   104 -FLSD-LLKTLG-----VQTVKTIIFRDR-----------TLETVVTRDVLNSGNGYMETSQPEN 150
             :|.| .|||||     :..||.:...|.           .||.:....:..:.....:.....|
Zfish   210 LYLGDNKLKTLGCDKSFLMNVKKLDLSDNKNLASKSFLGLKLENITYLRLRFTNISIFKLLTYPN 274

  Fly   151 ITTWHFGSVPGLKKFKFFSHVPELQESIFHGFDTLRDL-------HLSVNVTTLPGNMLSTVNGT 208
            :..||. ...|||          |:.|  |...:|..|       ||.:....|..|.:    |.
Zfish   275 VHPWHI-DFSGLK----------LKNS--HALSSLCVLMRNHSHEHLQIPKMLLQSNSI----GA 322

  Fly   209 LKTLT-----------------IESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQL----Q 252
            ||..|                 ::|.|.:.|    |....||::|.:.     |....:|    :
Zfish   323 LKNNTFRYCPSITREMDLSRNELKSAGCLQF----LHNQTQLKSLKME-----HNHLTKLTSCNK 378

  Fly   253 PHFFGSMTNLEEVRLASATSSVNRSM------FKGTNKLQLIKMNGN----DDLMELPGEIFLDQ 307
            .....|:|||        :...||.:      |..|.||:::::|.|    .|...|.|     .
Zfish   379 AEIHNSLTNL--------SYRYNRILQISGYAFSNTPKLEILELNINIIAYMDHKALSG-----L 430

  Fly   308 VNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMS 372
            .:||||.|..|.:..::.|.|:.|.||..|:|..|.:..:.:..|..|:.|::|.|..|.::.:.
Zfish   431 KDLKTLRLDNNLLSDIYNDSFEDLTNLKTLNLRNNEIAVIFNYTFQNLSKLDILDLGGNKISQLK 495

  Fly   373 PSVFQDVVSL-------NYIEMVNTQFYG---ATL----LMNYEAVVCTNDEACQYKSAEWQCD- 422
            |..|..:.||       |:::|::...:|   .||    |.....|..|......:|:.....|
Zfish   496 PHAFDGLYSLTNLYLDRNHLKMIDVVLFGKLSGTLQVLDLQGNMIVYFTEHTHSPFKNMSRLYDL 560

  Fly   423 -------------PRCICWVQRSVGSL------IVDCRGTSLEELPDLPRTTLLSTVLKVGN--- 465
                         ||.......|:.||      |:.....:.::|.:|...||.::...|..
Zfish   561 KLNGQQPNGINLLPRAFFRGLTSLKSLYLTNNHIIGFGDETFDDLKNLDYLTLDNSCAGVAQLQS 625

  Fly   466 ---NSLTSLPTVS-EHSG--------YANVSG---LFLSDNNLTSLGSG--DQLPDNLTHLDVRG 513
               .||..|.|:| |:.|        :.|::|   |.|:.|.:.||...  |.| .|||::|:|
Zfish   626 GIFKSLQKLRTLSLENMGIKSFSKDVFGNLTGLKTLHLNRNPMMSLDISLLDNL-TNLTYIDMR- 688

  Fly   514 NQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQ-RVRDIADIVCTKQKKS 577
                                      ..|::|||.:..|..:...|.: :...:.:|.|.....|
Zfish   689 --------------------------SCPLSCGCHNSDLQNWTIMNKRLQFPHLFNITCPDHPGS 727

  Fly   578 FQQMEAFELCPSYV---LLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWWVSEE--- 636
            :  ...|:....|:   |........|.|::.|:.:.|:....:.|   |...:...|..|:
Zfish   728 Y--FHNFDTKVCYLDIELYFFSSTSTLTILLTLIPLLYVKLYWKFK---YGYYVFRSWFGEQWRR 787

  Fly   637 --ELDKDKTYDAFISYSHKDEE-LISKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDS 698
              :.::...||||:||:..||: ::.:|||.||..  .||||||.||:.:|..|.:.||..|..|
Zfish   788 LRDQEEKYNYDAFVSYNSADEDWVMEQLLPNLEGS--SFRLCLHHRDFELGRDIVDNIVAAVYGS 850

  Fly   699 KRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDSELRAYLKL----- 758
            ::.|.|:||.|:.|.|..:|.::|.....|:.:..::::....:.     :.:|.||.::
Zfish   851 RKTICVVSQSFLRSEWCSLEIQLASYRLFQEMQDVLLLVFLEPIP-----ERQLSAYHRMRKVML 910

  Fly   759 -NTYLKW-----GDP-----LFWSKLYYAM 777
             .|||:|     .||     |||::|..|:
Zfish   911 KKTYLQWPGSNCSDPNSAKELFWNQLKRAL 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_477438.1	LRR	184..>541	CDD:443914	100/448 (22%)
		leucine-rich repeat	185..207	CDD:275380	6/28 (21%)
		leucine-rich repeat	209..232	CDD:275380	7/39 (18%)
		leucine-rich repeat	233..261	CDD:275380	5/31 (16%)
		leucine-rich repeat	262..284	CDD:275380	5/27 (19%)
		leucine-rich repeat	285..309	CDD:275380	6/27 (22%)
		leucine-rich repeat	310..333	CDD:275380	9/22 (41%)
		leucine-rich repeat	334..357	CDD:275380	6/22 (27%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	445..482	CDD:275380	12/51 (24%)
		leucine-rich repeat	483..505	CDD:275380	8/26 (31%)
		TIR	643..779	CDD:214587	51/152 (34%)
tlr21	NP_001186264.2	None