DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr12

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001102152.1	Gene:	Tlr12 / 362604	RGDID:	1559145	Length:	904	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	181/849 - (21%)
Similarity:	296/849 - (34%)	Gaps:	229/849 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PDEYAMLLEVSE-----PGASLYMSYYASTELQWLPRFNISSLVKIEFDAYIFWPEKFLSDLLKT 111
            ||.:..|:.:..     |..:........:.|||| ...||.|......|.||      .||::.
  Rat   136 PDAFGDLISLQRLHFCGPCLNKKAGVRLPSSLQWL-SVTISCLQDSGELAGIF------PDLVQN 193

  Fly   112 LGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQPENI----TTWHFGSVPGLKKFKFFSHVP 172
            ...:...|:    :.|:..:.:.:..:..|.::..|.|.:    |....|:|.||
  Rat   194 SSSRASWTL----KKLDLSLNQKLKMATPGSLQGLQVEILDLRKTQLDAGAVKGL---------- 244

  Fly   173 ELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLS 237
                    |...|..|:.......|...  :..:..|:.|.::...|.:.....|.....|..||
  Rat   245 --------GLQKLNVLYAPTATAELAAE--TAAHFELQGLNVDRSKIGNISQEALASCHSLETLS 299

  Fly   238 LALIHPFHERD---KQLQPHFFGSMTNLEEVRLASATSSVNRSMFKGTNKLQ--LIKMNGNDDLM 297
            |:        |   .:|.|.|..:|..|..:.||.             |:||  ::.||...|:.
  Rat   300 LS--------DTGLTKLPPGFLAAMPRLRRLNLAG-------------NQLQSTMLCMNETGDVS 343

  Fly   298 ELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLR 362
                       .|.|||||.|.:..|....|..|.:|..|.|..|:|.:|....|..|..|..|:
  Rat   344 -----------GLSTLDLSGNGLRILPPATFSCLPHLRELLLQDNQLLSLEGHPFQDLQQLETLK 397

  Fly   363 LNKNSLTAMSPSVFQDVVSLNYIEMVNTQ--------FYGATLL---------MNYEAVVCTNDE 410
            |::|.|..:..:....:.:|..:.:::||        |:||..|         ::..||:..
  Rat   398 LDRNPLLNLGKNCLAALPALTTLSLLDTQILHSPDAGFWGARSLHTLHLSLPPLSAPAVLSL--- 459

  Fly   411 ACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVS 475
            .....|.|....|....|.             .|....|.|...|:....||:|..:.:.:....
  Rat   460 PMYLTSLELHVTPGLKHWT-------------LSPNIFPFLETLTINGRGLKLGVQNASEVFPAL 511

  Fly   476 EHSGYANVSGLFLSDNNLTSLGSGD-------QLPDNLTHLDVRG-------------NQIQSLS 520
            :|        |||..|:|.:..|.|       ||| .|..|.|.|             ..:|.|.
  Rat   512 QH--------LFLLQNSLDAFCSQDASSIFLWQLP-KLQSLKVWGAGSNSRPCLITGLPSLQELK 567

  Fly   521 DEFLLFLQEPNNTMTLSLSGN-P-------ITCGCESLSLLFFVRT------------------- 558
            .|.|..:.:|.:.....|.|: |       .:.|.:|||...|.|.
  Rat   568 LESLQSITQPRSVQLEELVGDLPQLQALQLSSTGLKSLSAAAFRRLHSLQALVLDSEKDLVLQDS 632

  Fly   559 ----NPQRVRDI----ADIVC----------TKQK-KSFQQMEAFELCPSYV------------- 591
                :||..|.:    :.:.|          .||. |::..:....|||..|
  Rat   633 LREYSPQMPRYVYILQSKLACQCANAWMELWVKQSTKTYVHIRDGHLCPGEVRVPARDSLISFLW 697

  Fly   592 --------LLISCVVGGLVIVICLLTVFYLMFQQELKIWL-YNNNLCLWWV----SEEELDKDKT 643
                    |.:......||:::.:|.    :.|.....|: |...|...|:    .:....|...
  Rat   698 DHCPQTLELKLFLASSALVLLLIVLP----LLQGARNTWIPYLRALFRIWLQGLRGQGNAGKRFL 758

  Fly   644 YDAFISYSHKDEE-LISKLLPKLESGPHP----FRLCLHDRDWLVGDCIPEQIVRTVDDSKRVII 703
            :|.|:|:..:|:. ::.:|||.|| |..|    .||||.:||:..|..:.:.:|.::..|:..:.
  Rat   759 FDVFVSHCRQDQGWVLEELLPALE-GFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMVSSRVTLC 822

  Fly   704 VLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRE--LEHMNGIDSELRAYLKLNTYLKWGD 766
            |||...:.:....:|.|:|....|......::::::.|  ..|      :|.:|.:|...|:.||
  Rat   823 VLSGPALCNPRCCLELRLATSLLLAAPSPPVLLLVFLEPISRH------QLPSYHRLARLLRRGD 881

  Fly   767 PLFW 770
            ...|
  Rat   882 YCLW 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	3/21 (14%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		leucine-rich repeat	233..261	CDD:275380	9/30 (30%)
		LRR_RI	<261..370	CDD:238064	32/110 (29%)
		leucine-rich repeat	262..284	CDD:275380	3/21 (14%)
		leucine-rich repeat	285..309	CDD:275380	5/25 (20%)
		LRR_8	309..368	CDD:290566	22/58 (38%)
		leucine-rich repeat	310..333	CDD:275380	10/22 (45%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	445..482	CDD:275380	7/36 (19%)
		LRR_8	459..516	CDD:290566	18/76 (24%)
		leucine-rich repeat	483..505	CDD:275380	10/28 (36%)
		LRR_4	486..521	CDD:289563	16/54 (30%)
		TIR	643..779	CDD:214587	36/135 (27%)
Tlr12	NP_001102152.1	leucine-rich repeat	71..93	CDD:275380
		leucine-rich repeat	94..116	CDD:275380
		leucine-rich repeat	117..144	CDD:275380	3/7 (43%)
		leucine-rich repeat	202..225	CDD:275380	2/26 (8%)
		leucine-rich repeat	226..270	CDD:275380	10/63 (16%)
		leucine-rich repeat	246..259	CDD:275381	2/12 (17%)
		LRR_8	270..329	CDD:290566	17/79 (22%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		LRR_4	294..331	CDD:289563	14/57 (25%)
		leucine-rich repeat	295..318	CDD:275380	9/30 (30%)
		leucine-rich repeat	319..344	CDD:275380	9/48 (19%)
		LRR_8	343..403	CDD:290566	22/70 (31%)
		LRR_RI	345..547	CDD:238064	57/226 (25%)
		leucine-rich repeat	345..368	CDD:275380	10/22 (45%)
		leucine-rich repeat	369..392	CDD:275380	8/22 (36%)
		leucine-rich repeat	393..416	CDD:275380	5/22 (23%)
		leucine-rich repeat	417..437	CDD:275380	4/19 (21%)
		leucine-rich repeat	441..510	CDD:275380	14/84 (17%)
		leucine-rich repeat	511..562	CDD:275380	15/59 (25%)
		leucine-rich repeat	563..591	CDD:275380	7/27 (26%)
		leucine-rich repeat	592..615	CDD:275380	6/22 (27%)
		TIR	759..900	CDD:214587	36/134 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020