DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr13

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_038956543.1	Gene:	Tlr13 / 317227	RGDID:	1562655	Length:	956	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	213/919 - (23%)
Similarity:	340/919 - (36%)	Gaps:	277/919 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LQWLPRF---NISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETVVTRDVLNSG 139
            :|.||.:   |:|:||.:..:..:.|  |......:.|          .:.||..:|...:.:..
  Rat    80 IQVLPPWSFTNLSALVDLRLEWNLIW--KIDEGAFRGL----------ENLTLLNLVENKIQSVN 132

  Fly   140 NGYMETSQPE-------NITTWHFGSVPGLKKFKFFS-----------------HVPELQ----- 175
            |.:...|..|       .||..|..:...|.|.|:.|                 |:|.|:
  Rat   133 NSFEGLSNLETLLLSHNQITHIHKDAFTPLVKLKYLSLSRNRISNFSGILEAVQHLPCLEHLDLI 197

  Fly   176 -ESIFHGFDTLRDL----HLSV---NVTTLPGNMLSTVNGT----------------LKTLT--- 213
             .||.:...:.|.|    |||.   |:|.|..:.||..|.|                ||||.
  Rat   198 NNSIMYLDHSPRSLVSLTHLSFEGNNLTELNFSTLSLPNLTNLSASQNGHGVIQDVYLKTLPQLQ 262

  Fly   214 ------------------IESPGIVSFGNPLLRELQQ-----------LRNLSLALIHPFH---- 245
                              :::..::...|   |||:.           ||||.:..|..||
  Rat   263 SLNLSGTVVKLEMLSAKHLQNVRVMDLSN---RELKHGHLNMKIVCYLLRNLPMLEILFFHKNAT 324

  Fly   246 --ERDKQLQP----------------HF----FGSMTNLEEVRLASATSS--------------- 273
              |..|||..                |.    |.::.:|:.:.|.....|
  Rat   325 NAEGIKQLAKCTRLLFLDLGQNSDLVHLNDSEFNALPSLQRLNLNKCQLSFISNKTWSSLQNLTI 389

  Fly   274 --VNRSMFKG--------TNKLQLIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVF 328
              ::.:.||.        ..:|:.:.::.| .:.||....|....:||.|:|:...|||:....|
  Rat   390 LDLSHNKFKSFPDFAFSPLKRLEFLSLSRN-PITELNNLAFSGLFSLKELNLAACWIVTIDRYSF 453

  Fly   329 KGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIE-MVNT-- 390
            ....||.:|||..|.:..|:...|.||..|:.|.|:.|.|..|..:.|..:..|.|:: |.|:
  Rat   454 TQFPNLEVLDLGDNNIRTLNHGTFQPLKKLHTLILSHNRLEIMESNAFSGLTGLRYLDLMYNSLS 518

  Fly   391 -----QFYG----ATLLMNYEAVVCTNDEACQY---------KSAEWQCDPRCICWVQRSVGSLI 437
                 .|.|    ..|.:.:..:........||         |....:.....|..|.|:....:
  Rat   519 YFHKHHFMGLEKLLVLKLGFNKITYETTRTLQYPPFMKLKSLKQLNLEGQKHGIQVVPRNFFQGL 583

  Fly   438 VDCRGTSLEEL----------------PDLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGL 486
                 :||:||                |.:..|.|..:..|.|:.||           |.| |.|
  Rat   584 -----SSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSL-----------YLN-SSL 631

  Fly   487 F----------LSDNNLTSL--GSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLS 539
            |          |.:|||.||  |....| .||....:|.|.::.::..   .|:...:.|...:.
  Rat   632 FQNLKRLKVLRLENNNLESLVPGMFSSL-QNLQVFSLRFNNLKVINQS---HLENLKSLMFFDVY 692

  Fly   540 GNPITCGCESLSL-----------LFFVRTNP-------QRVRDIADIVCTKQKKSFQQMEAFEL 586
            ||.:.|.|::|..           :.|:|:.|       ..:.|..|.:|.           |:|
  Rat   693 GNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPNSQSLLIDFDDAMCN-----------FDL 746

  Fly   587 CPSYVLLISCVVGGLVIVICLLTVFYLMFQQEL--KIWLYNNNLC-LWWVSE-EELDKDKTYDAF 647
            ...|.|....||        |.|:.:..|..::  .:| |...:| .|:::: .:.:|...||||
  Rat   747 GKVYFLCSFSVV--------LSTMVFSWFSAKMIASLW-YGLYICRAWYLTKWHKTEKKFLYDAF 802

  Fly   648 ISYSHKDEELISK-LLPKLESGPH-PFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFI 710
            :|:|..||..:.| |:|.||.|.. .|:||||.||:..|..|.|.|...::.|::.:.|:|.|::
  Rat   803 VSFSATDEAWVYKELVPALEEGSQTTFKLCLHQRDFEPGIDIFENIQNAINASRKTLCVVSNHYL 867

  Fly   711 DSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS--ELRAYLKLNTYLKWGD-----PL 768
            .|.|.|:|.::|......:.:..||:|...|:.:.. :.|  .||..:...|::.|.|     ||
  Rat   868 HSEWCRLEVQLASMKMFYEHKDVIILIFLEEIPNYK-LSSYHRLRKLINRQTFITWPDSAHQQPL 931

  Fly   769 FWSKLYYAM 777
            ||:::..|:
  Rat   932 FWARIRNAL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	10/28 (36%)
		leucine-rich repeat	209..232	CDD:275380	8/43 (19%)
		leucine-rich repeat	233..261	CDD:275380	13/53 (25%)
		LRR_RI	<261..370	CDD:238064	33/133 (25%)
		leucine-rich repeat	262..284	CDD:275380	5/46 (11%)
		leucine-rich repeat	285..309	CDD:275380	5/23 (22%)
		LRR_8	309..368	CDD:290566	22/58 (38%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	445..482	CDD:275380	11/52 (21%)
		LRR_8	459..516	CDD:290566	21/68 (31%)
		leucine-rich repeat	483..505	CDD:275380	11/33 (33%)
		LRR_4	486..521	CDD:289563	14/46 (30%)
		TIR	643..779	CDD:214587	49/144 (34%)
Tlr13	XP_038956543.1	leucine-rich repeat	47..69	CDD:275380
		leucine-rich repeat	70..93	CDD:275380	4/12 (33%)
		PLN00113	72..>518	CDD:215061	100/453 (22%)
		leucine-rich repeat	94..117	CDD:275380	5/34 (15%)
		leucine-rich repeat	118..140	CDD:275380	4/21 (19%)
		leucine-rich repeat	141..164	CDD:275380	5/22 (23%)
		leucine-rich repeat	165..190	CDD:275380	3/24 (13%)
		leucine-rich repeat	191..213	CDD:275380	5/21 (24%)
		leucine-rich repeat	214..236	CDD:275380	8/21 (38%)
		leucine-rich repeat	237..260	CDD:275380	5/22 (23%)
		leucine-rich repeat	261..283	CDD:275380	0/21 (0%)
		leucine-rich repeat	338..362	CDD:275380	2/23 (9%)
		PLN00113	360..>710	CDD:215061	83/371 (22%)
		leucine-rich repeat	363..386	CDD:275380	3/22 (14%)
		leucine-rich repeat	387..410	CDD:275380	2/22 (9%)
		leucine-rich repeat	411..434	CDD:275380	5/23 (22%)
		leucine-rich repeat	435..458	CDD:275380	8/22 (36%)
		leucine-rich repeat	459..482	CDD:275380	9/22 (41%)
		leucine-rich repeat	483..506	CDD:275380	7/22 (32%)
		leucine-rich repeat	507..530	CDD:275380	6/22 (27%)
		leucine-rich repeat	531..585	CDD:275380	7/58 (12%)
		leucine-rich repeat	638..661	CDD:275380	8/23 (35%)
		leucine-rich repeat	662..683	CDD:275380	4/23 (17%)
		TIR	799..943	CDD:214587	49/143 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920