DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr2

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_008759324.3	Gene:	Tlr2 / 310553	RGDID:	735138	Length:	831	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	200/890 - (22%)
Similarity:	338/890 - (37%)	Gaps:	249/890 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PGASLY----------MSYYASTELQWLPRFNISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVK 118
            |||||.          :..::.|.|..|.|.....:::.   .::||      .|:..:|:..
  Rat    13 PGASLLCFSFISGASELHLWSETALWKLQRVKSQRMLQA---LWLFW------ILMAVIGLSR-- 66

  Fly   119 TIIFRDRTLETVVTRDVLN--SGNGYMETSQPENITTWHFGSVPGLKKFKF-FSHVPELQESIFH 180
                ...:.:..::.|...  .|:....||.|..:|.       ..||... |:.:    ..|.|
  Rat    67 ----EGHSAQASLSCDAAGVCDGSSRSFTSIPSGLTA-------NTKKLDLSFNKI----TYIGH 116

  Fly   181 GFDTLRDLHLSVN--VTTLPGNMLSTVN-------GTLKTLTIESPGIVSFGNPLLRELQQLRNL 236
            |     ||...||  |.||..:.::|:.       |:|:.|.:.:..:.|..:...|.|..|:.|
  Rat   117 G-----DLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSSSWFRPLSSLKYL 176

  Fly   237 SLALIHPFHERDKQLQPHFFGSMTNLEEVRLASAT--SSVNRSMFKGTNKLQLIKMN----GNDD 295
            :| :.:|:....   :...|.::|||:.:|:.:..  |.:.|..|.|...|..:::.    ||.:
  Rat   177 NL-MGNPYRTLG---ETSLFSNLTNLQNLRVGNVDTFSEIRRIDFAGLTSLNELEIQVLSLGNYE 237

  Fly   296 LMELPGEIFLDQVNLKTLDLSCNA-IVTLHEDVFKGLGNLTLLD--LSKNRLTNLS-STIFAPLT 356
            ...|  :...|..:| ||.||.:| ::.:..|:...:..|.|.|  |::.:.:.|| ..|.:|:.
  Rat   238 SRSL--QSIRDIYHL-TLHLSESAFLLGIFADILSSVRYLELRDTNLARFQFSELSVDEINSPMK 299

  Fly   357 SL-------------NVLRLNK---------------NSLTAMSPSVFQDVVSLNYIEMVN---- 389
            .|             .:|:|.:               |.:...:||....|..|..:|.|.
  Rat   300 KLAFRNADLTDKSFNELLKLLRYILELMEVEFDHCTLNGVGNFNPSESDVVRELGKVETVTIRSL 364

  Fly   390 --TQFY-------GATLLMNYEAVVCTNDEA----CQY----KSAEW----------------QC 421
              .|||       ..:||...:.:...|.:.    |.:    ||.|:                .|
  Rat   365 HIPQFYLFYDLSTVYSLLEKVKRITVENSKVFLVPCSFSQHLKSLEFLDLSENLMVEEYLKNSAC 429

  Fly   422 DPRCICWVQRSVGSLI------------------------VDCRGTSLEELPD------------ 450
            :..   |  .|:.||:                        :|....|.:.:||
  Rat   430 EGG---W--PSLQSLVLSQNHLRSIRKTAEILLTLKNLTALDISKNSFQPMPDSCQWPGKMRFLN 489

  Fly   451 ------------LPRTTLLSTVLKVGNNSLTS----LPTVSEHSGYANVSGLFLSDNNLTSLGSG 499
                        :|:|.   .||.|.||:|.|    ||.:.|         |::|.|.|.:|...
  Rat   490 LSSTGIQAVKTCIPQTL---EVLDVSNNNLDSFSLFLPRLQE---------LYISRNKLKTLPEA 542

  Fly   500 DQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVR 564
            ...| .|..:.:|.|.|.:.|.:.|....:   ..||....|...|.||   ||.|:...|..|.
  Rat   543 SLFP-VLQVMKIRENAISTFSKDQLGSFPK---LETLEAGDNHFICSCE---LLSFILERPALVH 600

  Fly   565 DIAD----IVCTKQKKSF-QQMEAFELCPSYV-----LLISCVVGGLVIVICLLTVFYLMFQQEL 619
            .:.|    .:|....:.. |:::  :..||.:     .|:|.|...|:::|.||......|.
  Rat   601 VLVDWPDSYLCDSPPRLHGQRLQ--DARPSVLECHQAALVSGVCCALLLLILLLGALCYHFH--- 660

  Fly   620 KIWLYNNNLCLW-WVSEEELDK-----DKTYDAFISYSHKDEELISKLL-PKLESGPHPFRLCLH 677
            .:|...   .:| |:..:...|     |..||||:|||.:|...:..|: .:||:...||:||||
  Rat   661 GLWYLR---MMWAWLRAKRKPKKAPCRDLCYDAFVSYSEQDSYWVENLMVQQLENSDPPFKLCLH 722

  Fly   678 DRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYREL 742
            .||::.|..|.:.|:.:::.|.:.:.|||::|:.|.|.:.|...::.....:.....|::|...:
  Rat   723 KRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLEPI 787

  Fly   743 EHMNGIDS---ELRAYLKLNTYLKWGDPL-------FWSKLYYAM 777
            | ...|..   :||..:...|||:|  ||       ||:.|..|:
  Rat   788 E-KKAIPQRFCKLRKIMNTKTYLEW--PLDEGQREVFWANLRTAI 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/30 (27%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..261	CDD:275380	5/27 (19%)
		LRR_RI	<261..370	CDD:238064	31/146 (21%)
		leucine-rich repeat	262..284	CDD:275380	6/23 (26%)
		leucine-rich repeat	285..309	CDD:275380	5/27 (19%)
		LRR_8	309..368	CDD:290566	19/90 (21%)
		leucine-rich repeat	310..333	CDD:275380	7/23 (30%)
		leucine-rich repeat	334..357	CDD:275380	8/25 (32%)
		leucine-rich repeat	358..381	CDD:275380	7/50 (14%)
		leucine-rich repeat	445..482	CDD:275380	14/64 (22%)
		LRR_8	459..516	CDD:290566	19/60 (32%)
		leucine-rich repeat	483..505	CDD:275380	6/21 (29%)
		LRR_4	486..521	CDD:289563	10/34 (29%)
		TIR	643..779	CDD:214587	46/146 (32%)
Tlr2	XP_008759324.3	leucine-rich repeat	101..124	CDD:275378	8/31 (26%)
		LRR_8	124..182	CDD:404697	14/58 (24%)
		leucine-rich repeat	125..148	CDD:275378	4/22 (18%)
		leucine-rich repeat	149..172	CDD:275378	5/22 (23%)
		leucine-rich repeat	173..197	CDD:275378	5/27 (19%)
		leucine-rich repeat	229..249	CDD:275380	4/21 (19%)
		leucine-rich repeat	250..270	CDD:275380	7/20 (35%)
		PRK15370	<387..>605	CDD:185268	49/241 (20%)
		leucine-rich repeat	409..435	CDD:275380	3/30 (10%)
		leucine-rich repeat	436..461	CDD:275380	2/24 (8%)
		leucine-rich repeat	462..484	CDD:275380	4/21 (19%)
		leucine-rich repeat	485..505	CDD:275380	1/19 (5%)
		leucine-rich repeat	506..525	CDD:275380	8/21 (38%)
		leucine-rich repeat	526..547	CDD:275380	7/30 (23%)
		leucine-rich repeat	548..571	CDD:275380	6/22 (27%)
		LRRCT	580..633	CDD:214507	14/57 (25%)
		TIR	687..831	CDD:214587	46/146 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920