DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr6

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	802	Identity:	176/802 - (21%)
Similarity:	294/802 - (36%)	Gaps:	259/802 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 KFFSHVPELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVN-------GTLKTLTIESPGI--VS 221
            |..:|||             :||..|....:|..|.:|.:.       ..|:.|.:....|  :.
  Rat    52 KNLTHVP-------------KDLSPSTKSLSLSQNSISDLQMSDISFLSELRVLRLSHNRIRRLD 103

  Fly   222 FGNPLL-RELQ-------QLRNLSLA-LIHPFH----ERDKQLQPHF--FGSMTNLEEVRLASA- 270
            ||..|| |:|:       ||:|:|.. :::..|    ..|.::.|.:  ||::..|..:.|::|
  Rat   104 FGVFLLNRDLEYLDVSHNQLQNISCCPMVNLKHLDLSFNDFEVLPVYKEFGNLRKLSFLGLSAAK 168

  Fly   271 ------------------TSSVNRSMFKG-TNKLQLIKMNGNDDLMEL---PGEIFLDQV----- 308
                              ...||..:..| |..||:    .|.:::.|   |..:|..||
  Rat   169 FRQLDLLPISHLHLSCVLLDLVNYQIKDGETESLQV----PNTNVLHLVFHPNSLFSVQVNISVN 229

  Fly   309 --------NLKTLDLSCNAIVTLHEDVFKG--LGNLTLLDLSKN-------------------RL 344
                    |:|..|.:|.:::....::.:|  |.||||..:..|                   .:
  Rat   230 ALGCLQLSNIKLNDENCQSLIIFLSELTRGPTLLNLTLQHIETNWKCFVRLLQFLWPRPVEYLNI 294

  Fly   345 TNLSST----------IFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLN----------YIEMVN 389
            .||:.|          :...|.||.:..:.......:..:::.....:|          :|.||.
  Rat   295 YNLTITESISRETFIYVETVLKSLKIEHVTNQVFLFVKDALYSVFAEMNIRMLTLSDTPFIHMVC 359

  Fly   390 TQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRG------------ 442
            .:|......:|:...|.| |...|.            |...:.:.:||:...|
  Rat   360 PEFPSTFAFLNFTQNVFT-DSIFQG------------CSTLKRLETLILQRNGLKNLFKVALMTK 411

  Fly   443 --TSLEELPDLPRTTLLS-----------------------------------TVLKVGNNSLTS 470
              :|||.| |:...:|.|                                   .||.:.||.:.|
  Rat   412 TMSSLETL-DVSLNSLNSHVYDRTCAWAESIRVLNLSSNVLSDSVFRCLPPKVKVLDLHNNRIVS 475

  Fly   471 LPTVSEH---SGYANVSGLFLSDNNLTSLGSGDQLP-----DNLTHLDVRGNQIQSLSDEFLLFL 527
            :|....|   ....||:..||:|           ||     .:|:.|.:..|.:...|.:   |.
  Rat   476 IPKDVTHLQALQELNVASNFLTD-----------LPGCGAFSSLSVLVIDHNSVSHPSSD---FF 526

  Fly   528 QEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIADIVCTKQKKSFQQ------MEAFEL 586
            |...|..:::...||..|.||   |..||:...|..|::.:......:..:..      ::.|.:
  Rat   527 QSCQNIRSITAGNNPFRCTCE---LREFVKNIGQASREVVEGWPDSYRCDYPDSIKGTPLQDFHM 588

  Fly   587 CP--SYVLLISCVVGGLVIV-------ICLLTVFYLMFQQELKIWLYNNNLCLW-W--------- 632
            .|  ...:|::..:|..:::       :||    |......|::        || |
  Rat   589 SPLSCDTILLTVTIGATLLLLAAIGASLCL----YFDLPWYLRM--------LWQWTQTRHRARN 641

  Fly   633 VSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVD 696
            :..|||.::..:.||:|||..|...: ::|||.||.  ...|:|||:|:::.|..|.|.|:..::
  Rat   642 IPLEELQRNLQFHAFVSYSEHDSAWVKNELLPNLEK--DDIRVCLHERNFVPGKSIVENIIHFIE 704

  Fly   697 DSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS---ELRAYLKL 758
            .|.:.|.|||.|||.|.|...|...|:.....:....:|:||...:: .|.|.|   :|||.:..
  Rat   705 KSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLEPIQ-QNNIPSRYHKLRALMAQ 768

  Fly   759 NTYLKWGDP-------LFWSKL 773
            .|||:|  |       |||:.|
  Rat   769 RTYLEW--PIEKGKRGLFWANL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/28 (21%)
		leucine-rich repeat	209..232	CDD:275380	9/32 (28%)
		leucine-rich repeat	233..261	CDD:275380	8/34 (24%)
		LRR_RI	<261..370	CDD:238064	32/175 (18%)
		leucine-rich repeat	262..284	CDD:275380	7/41 (17%)
		leucine-rich repeat	285..309	CDD:275380	8/39 (21%)
		LRR_8	309..368	CDD:290566	17/89 (19%)
		leucine-rich repeat	310..333	CDD:275380	5/24 (21%)
		leucine-rich repeat	334..357	CDD:275380	8/51 (16%)
		leucine-rich repeat	358..381	CDD:275380	1/22 (5%)
		leucine-rich repeat	445..482	CDD:275380	13/74 (18%)
		LRR_8	459..516	CDD:290566	17/64 (27%)
		leucine-rich repeat	483..505	CDD:275380	6/26 (23%)
		LRR_4	486..521	CDD:289563	8/39 (21%)
		TIR	643..779	CDD:214587	50/142 (35%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	6/24 (25%)
		leucine-rich repeat	65..88	CDD:275378	3/22 (14%)
		LRR_8	87..144	CDD:290566	14/56 (25%)
		leucine-rich repeat	89..112	CDD:275378	7/22 (32%)
		leucine-rich repeat	113..133	CDD:275378	5/19 (26%)
		leucine-rich repeat	134..158	CDD:275378	5/23 (22%)
		leucine-rich repeat	369..385	CDD:275380	5/28 (18%)
		LRR_RI	<380..>500	CDD:238064	24/143 (17%)
		LRR_8	388..451	CDD:290566	10/63 (16%)
		leucine-rich repeat	390..415	CDD:275380	3/24 (13%)
		leucine-rich repeat	416..440	CDD:275380	6/24 (25%)
		leucine-rich repeat	441..462	CDD:275380	0/20 (0%)
		LRR_8	461..516	CDD:290566	16/65 (25%)
		leucine-rich repeat	463..485	CDD:275380	7/21 (33%)
		leucine-rich repeat	486..508	CDD:275380	7/32 (22%)
		leucine-rich repeat	510..531	CDD:275380	5/23 (22%)
		LRRCT	540..594	CDD:214507	12/56 (21%)
		TIR	652..791	CDD:214587	50/142 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920