DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr5

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001139300.1	Gene:	Tlr5 / 289337	RGDID:	631351	Length:	871	Species:	Rattus norvegicus

Alignment Length:	986	Identity:	216/986 - (21%)
Similarity:	356/986 - (36%)	Gaps:	323/986 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VWLFFALLVLRSATGQ------IIPLPTFCLGLSPQCTCAAEGNVVRFHCPDEYAMLLEVSEPGA 66
            :|.|::|...|....|      ::.:.:..|.:||   |.::|.:..|.              |.
  Rat     1 MWCFYSLFSHRIMAYQLDLLIGVVFMASPVLEMSP---CFSDGRIALFR--------------GC 48

  Fly    67 SLYMSYYASTELQW--------LPRFN-ISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIF 122
            :|       |::.|        |..|| ||::|...|...    |:.   ||..||.|..:..|.
  Rat    49 NL-------TQIPWVLNTTERLLLSFNYISTVVTTSFPLL----EQL---LLLELGTQYARLTIG 99

  Fly   123 RD--RTLETVVTRDVLNSGNGYMETSQPENITTWHFGSVPGLKKFKFFS---------------- 169
            ::  |.|..:   .:|:.|...:|...|:     .|..:|.|.:.:.|.
  Rat   100 QEAFRNLPNL---RILDLGQSQIEVLNPD-----AFQGLPHLFELRLFDCGLSNAVLRDAYFRNL 156

  Fly   170 -------------HVPELQESIFHGFDTLRDLHLSVN-VTTLPGNMLSTVNG-TLKTLTIESPGI 219
                         |...|..| |....:|.|::.|.| :.||..:.|..:.| ||....::|..:
  Rat   157 NSLARLDLSANEIHSLHLHSS-FQELSSLSDINFSFNRIFTLCEDELQPLQGRTLSFFGLKSTSL 220

  Fly   220 VS--------FGNPLLRELQQLRNLSL-----------------------ALIHPFH-------- 245
            .|        ..|| ||.: :|..|.|                       :||..:|
  Rat   221 FSRVFVDWEACRNP-LRGI-RLETLDLSENGWTAAILGNFSHTIQGSHISSLILTYHIMGSGFGF 283

  Fly   246 ----ERDK----------------------QLQPHFFGSMTNLEEVRLA-SATSSVNRSMFKGTN 283
                :.|:                      .|.|..|.::.:|:::.|| :..:.::...|.|.:
  Rat   284 QNIKDPDQSTFASLARSSVLQLDLSHGYIFSLNPRLFETLKDLKKLNLAFNKINKISDYAFHGLD 348

  Fly   284 KLQLIKMN-------GNDDLMELPGEIFLD-QVN---------------LKTLDLSCNAIVTLH- 324
            .||::.::       .|.:...||...:|| |.|               |:||||..||:.|:.
  Rat   349 SLQILNLSYNLLGELYNSNFYGLPSIAYLDLQRNHIGIIQDRTFRLLKKLQTLDLRDNALKTIGF 413

  Fly   325 ----EDVFKGLGNLT----------LLDLSKNRLTNLSSTIF-APLTSLNVLRLNKNSLTAMSPS 374
                :.|..|...||          .::||:|.|.|||...| ..:..|..|.||:|.|::.|
  Rat   414 IPSVQMVLLGSNKLTHLPHVRFTANFIELSENGLENLSDLYFLLRIPGLQFLILNQNRLSSCS-- 476

  Fly   375 VFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVD 439
                  :::|....|.......|..|...:.             |:..   :||
  Rat   477 ------NVDYAPSQNLSLEQLFLAENMLQLA-------------WETG---LCW----------- 508

  Fly   440 CRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPD 504
                      |:.:......:|.:.||.|..||. ...:|...:..|.||.|.||.|..| .||.
  Rat   509 ----------DIFKGLSRLQILYLNNNYLNFLPP-GIFNGLVALRMLSLSANRLTMLSPG-SLPA 561

  Fly   505 NLTHLDVRGNQIQSLSDEFLLFLQEP---NNTMTLSLSGNPITCGCE-SLSLLFFVRTNPQRVRD 565
            ||..||:..||         ||..:|   ::...|.::.|...|.|| |..:::..:||......
  Rat   562 NLEILDISRNQ---------LFSPDPGLFSSLRALDITHNEFICDCELSTFIVWLNQTNVTLFGS 617

  Fly   566 IADIVC------------TKQKKSFQQMEA--------FELCP---SYVLLISCVVGGL--VIVI 605
            .||:.|            ....|...:.||        |.||.   :..|:|:.:|...  :..:
  Rat   618 PADVYCMYPNSLLGSSLYNISTKDCDEEEAVRSLNFSLFILCTVTLTLFLVITLIVTKFRGICFL 682

  Fly   606 CLLTVFYLMFQQELKIWLYNNNLCLWWVSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLE--- 666
            |..|:..|||:.:.:    |.....:           .|||:..:|.||.|.. :.||..|:
  Rat   683 CFKTIQKLMFKGKFR----NPEPSAY-----------RYDAYFCFSSKDFEWAQNALLKHLDAQY 732

  Fly   667 SGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKR 731
            |..:..|||..:||::.|:.....|...|..|::.:.::|:||:...|....||.|....|.|.:
  Rat   733 SSQNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRCLSDLK 797

  Fly   732 KRIIIIL------YRELEHMNGIDSELRAYLKLNTYLKWGDPL-----FWSKLYYAMPHNRRVLK 785
            :.:|:::      |:.:.|     ..:|.:|:...||:|.:.|     |..||      :..:||
  Rat   798 RVLIVVVVGSLPQYQLMRH-----ETIRGFLQKQQYLRWPEDLQDVDWFLDKL------SGCILK 851

  Fly   786 GQ--KKHAGPL 794
            .:  ||.:.|:
  Rat   852 EEKGKKRSSPI 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	7/30 (23%)
		leucine-rich repeat	233..261	CDD:275380	10/84 (12%)
		LRR_RI	<261..370	CDD:238064	40/148 (27%)
		leucine-rich repeat	262..284	CDD:275380	5/22 (23%)
		leucine-rich repeat	285..309	CDD:275380	8/31 (26%)
		LRR_8	309..368	CDD:290566	26/89 (29%)
		leucine-rich repeat	310..333	CDD:275380	10/27 (37%)
		leucine-rich repeat	334..357	CDD:275380	10/33 (30%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	445..482	CDD:275380	8/36 (22%)
		LRR_8	459..516	CDD:290566	22/56 (39%)
		leucine-rich repeat	483..505	CDD:275380	10/21 (48%)
		LRR_4	486..521	CDD:289563	16/34 (47%)
		TIR	643..779	CDD:214587	41/150 (27%)
Tlr5	NP_001139300.1	LRR_8	<96..143	CDD:404697	11/54 (20%)
		PLN00113	<108..>384	CDD:215061	52/286 (18%)
		leucine-rich repeat	109..132	CDD:275380	5/30 (17%)
		leucine-rich repeat	133..158	CDD:275380	2/24 (8%)
		leucine-rich repeat	159..183	CDD:275380	4/24 (17%)
		leucine-rich repeat	184..217	CDD:275380	10/32 (31%)
		leucine-rich repeat	240..301	CDD:275380	7/60 (12%)
		leucine-rich repeat	302..325	CDD:275380	3/22 (14%)
		LRR	314..>578	CDD:227223	77/319 (24%)
		LRR_8	326..384	CDD:404697	14/57 (25%)
		leucine-rich repeat	326..349	CDD:275380	5/22 (23%)
		leucine-rich repeat	350..373	CDD:275380	4/22 (18%)
		leucine-rich repeat	374..397	CDD:275380	4/22 (18%)
		leucine-rich repeat	398..432	CDD:275380	12/33 (36%)
		leucine-rich repeat	433..461	CDD:275380	8/27 (30%)
		leucine-rich repeat	462..487	CDD:275380	9/32 (28%)
		leucine-rich repeat	488..516	CDD:275380	6/64 (9%)
		leucine-rich repeat	517..540	CDD:275380	7/23 (30%)
		leucine-rich repeat	541..559	CDD:275380	8/18 (44%)
		leucine-rich repeat	563..586	CDD:275380	8/31 (26%)
		PCC	567..>645	CDD:188093	18/86 (21%)
		TIR	706..856	CDD:396246	43/160 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920